George Weinstock, Ph.D.

Professor, Evnin Family Chair and Director of Microbial Genomics

Leverages advanced technologies to investigate infectious diseases, human and other mammalian microbiomes, and their clinical impact.

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Location

Farmington, CT

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207-288-6000

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In the last decade, leaps in DNA sequencing technologies have transformed our ability to collect and analyze genomic information. This revolution has opened up entirely new areas of study from human to microbial and infectious disease research. Currently, understanding the microbiome (the vast collection of microbes in our body with which we coexist), its interactions with its host (us) and its contributions to health and disease is a vital new research area that he is focusing on. The Weinstock Laboratory leverages advanced technologies to investigate infectious diseases and mammalian microbiomes.

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Consortia papers

Fraser, C.M., Norris, S.J., Weinstock, G.M., White, O., Sutton, G.G., Dodson, R., Gwinn, M., Hickey, E.K., Clayton, R., Ketchum, K.A., Sodergren, E., Hardham, J.M., McLeod, M.P., Salzberg, S., Peterson, J., Khalak, H., Richardson, D., Howell, J.K., Chidambaram, M., Utterback, T., McDonald, L., Artiach, P., Bowman, C., Cotton, M.D., Fujii, C., Garland, S., Hatch, B., Horst, K., Roberts, K., Watthey, L., Weidman, J., Smith, H.O., and Venter, J.C.: Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 281:375-388, 1998.

International Human Genome Sequencing Consortium: Initial sequencing and analysis of the human genome. Nature 409: 860-921, 2001.

Gibbs, R. A. et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428, 493-521, 2004.

International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 431:931-45, 2004.

Wheeler, D.A., Srinivasan, M., Egholm, M., Shen, Y., Chen, L., McGuire, A., He, W., Chen, Y.-J., Makhijani, V., Roth, G.T., Gomes, X., Tartaro, K., Niazi, F. Turcotte, C.L., Irzyk, G.P., Lupski, J.R., Chinault, A.C., Song, X.-Z., Liu, Y., Yuan, Y., Nazareth, L., Qin, Xiang., Muzny, D.M., Margulies, M., Weinstock, G.M., Gibbs, R.A., Rothberg,  J.M. The complete genome of an individual by massively parallel DNA sequencing. Nature 452:872-876, 2008.

The Human Microbiome Jumpstart Reference Strains Consortium, Nelson KE, Weinstock GM, Highlander SK, Worley KC, Creasy HH, Wortman JR, Rusch DB, Mitreva M, Sodergren E, Chinwalla AT, Feldgarden M, Gevers D, Haas BJ, Madupu R, Ward DV, Birren BW, Gibbs RA, Methe B, Petrosino JF, Strausberg RL, Sutton GG, White OR, Wilson RK, Durkin S, Giglio MG, Gujja S, Howarth C, Kodira CD, Kyrpides N, Mehta T, Muzny DM, Pearson M, Pepin K, Pati A, Qin X, Yandava C, Zeng Q, Zhang L, Berlin AM, Chen L, Hepburn TA, Johnson J, McCorrison J, Miller J, Minx P, Nusbaum C, Russ C, Sykes SM, Tomlinson CM, Young S, Warren WC, Badger J, Crabtree J, Markowitz VM, Orvis J, Cree A, Ferriera S, Fulton LL, Fulton RS, Gillis M, Hemphill LD, Joshi V, Kovar C, Torralba M, Wetterstrand KA, Abouellleil A, Wollam AM, Buhay CJ, Ding Y, Dugan S, Fitzgerald MG, Holder M, Hostetler J, Clifton SW, Allen-Vercoe E, Earl AM, Farmer CN, Liolios K, Surette MG, Xu Q, Pohl C, Wilczek-Boney K, Zhu D. A Catalog of Reference Genomes from the Human Microbiome. Science. 328:994-999, 2010. PMID: 20489017

Human Microbiome Project Consortium. A framework for human microbiome research. Nature 486:215-221, 2012. doi: 10.1038/nature11209. PMID: 22699610.

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486:207-214, 2012. doi: 10.1038/nature11234. PMID: 22699609.