Identify early causative events that underlie cognitive deficits associated with ‘normal’ aging and Alzheimer’s disease
Alzheimer’s disease currently affects 5 million Americans and despite decades of research we do not yet have a treatment that can even substantially slow the devastating symptoms let alone cure the inevitable cognitive decline. Work in my laboratory to address this situation was launched not by asking what causes the disease, but by posing the counterintuitive question: “What makes some people resistant to the disease”? In looking for the answer to this disarmingly simple question my laboratory is now leading a unique attack on Alzheimer’s and age-related dementia by focusing on identifying and validating the genetic factors that protect individuals from cognitive decline.
Integrated with broad collaborative efforts, my team of interns, research scientists, postdoctoral fellows and graduate students are working on a variety of projects that seek to understand these “genetic mechanisms and biomarkers of resilience” with the ultimate goal of turning these protective factors into novel therapies.
Deconstructing Alzheimer's Disease Complexity to Identify Resilience Mechanisms
Catherine Kaczorowski Promotion Seminar
B.A. (Summa cum Laude) Psychology, University of Wisconsin at Milwaukee, May 2000
Ph.D. of Neuroscience, Northwestern University Institute for Neuroscience, December 2006
Postdoctoral Trainee, University of Wisconsin at Milwaukee, January 2007-January 2009
Kern Innovation Fellow and Postdoctoral Trainee, Medical College of Wisconsin, January 2009 – June 2012
2019 Finalist, Glenn Foundation for Medical Research Breakthroughs in Gerontology Award
2018 Evnin Family Endowed Chair in Alzheimer’s Research
Sponsor AARF fellowship grant award (PI: Amy Dunn, postdoc. fellow)
Dorothy Dillon Eweson Lecture Series on the Advances in Aging Research Award
International Behavioural and Neural Genetic Society Young Investigator Award
2017 The Jackson Laboratory nominee for Blavatnik National Award
Glenn Award for Research in Biological Mechanisms of Aging
Grant from the Wright Family Fund
Invited Chair of the Neuroscience 2017 Nanosymposium: "Protective and Pathogenetic Mechanisms in Alzheimer's Disease". International
meeting of the Society for Neuroscience, Washington, DC
Invited panelist, BIOME 2017 Annual Conference, Portland, ME
2016 BrightFocus Foundation Award (PI: Kaczorowski)
Graduate Student Executive Committee Outstanding Mentor Award, UTHSC
2015 ponsor AFAR fellowship grant award (PI: Lynda Wilmott, postdoc. fellow)
Patriot Award, Employer Support of the Guard and Reserve, Department of the Secretary of Defense
Sponsor F31 NIA NRSA grant award (PI: Sarah Neuner, graduate student)
2014 NIA Butlers-Williams Scholar
American Federation on Aging Research Young Investigators Award, UTHSC
UT Nominee for Searle Scholar Award
2013 NIH R00 Pathway to Independence Award
2012 NIH K99 Pathway to Independence Award
Postdoctoral Travel Award, Medical College of Wisconsin Postdoctoral Assoc.
Cold Spring Harbor Proteomics Course Travel Award
2011 Society for Neuroscience Poster Presentation Award, Milwaukee WI
2009 Kern Innovation Center Fellowship (3 year award), Biotechnology and Bioengineering Center, MCW
2003 NIMH NRSA Predoctoral Fellowship Award (3 year award)
Cold Spring Harbor Ion Channel Physiology Course Award
2002 NIH Neuroscience in the Early Years Training Grant Award (2 year award)
Northwestern Graduate School University Scholar Award (2 year award)
NIH Neuroscience in the Early Years Travel Award
Gordon Research Conference on Synaptic Transmission Travel Award
2001 Northwestern University Fellowship Award (2 year award)
Northwestern University Institute for Neuroscience Award (2 year award)
2000 Commencement Honors: Summa cum Laude, University of Wisconsin-Milwaukee
Golden Key National Honor Society, University of Wisconsin-Milwaukee
1999 Phi Kappa Phi National Honor Society, University of Wisconsin-Milwaukee
Phi Chi National Honor Society, University of Wisconsin-Milwaukee
Outstanding Tutor Award, University of Wisconsin-Milwaukee
All-American Scholar, University of Wisconsin-Milwaukee
Present Trainees (2020)
David Anderson, Research Intern
Amy Dunn, Postdoctoral Fellow
Brianna Gurdon, Research Intern
Niran Hadad, Postdoctoral Fellow
Sarah Heuer, graduate student, Genetics Track
Jill King. Postdoctoral Fellow
Andrew Ouellette, Graduate Student, University of Maine, GSBSE program
Maria Telpoukhovskaia, Research Scientist
Past Trainees (2014-2019)
Iman Abutineh, undergraduate research assistant: Immunohistochemistry (CBU)
Glen Acosta, Postdoctoral Fellow
Natalia Bachelder, Research Intern, The Jackson Laboratory
Alex Bednarek, Research Intern, The Jackson Laboratory
John Buttross, undergraduate research assistant: Systems genetics of AD
Patricia Doyle, Research Intern, The Jackson Laboratory
Brianna Gurdon, summer student, The Jackson Laboratory
Grace Fisher, Research Intern, The Jackson Laboratory
Kevin Hope, graduate student (EPhys), Neuroscience Track, UTHSC
Andrea Mirow, summer student, undergraduate at Amherst College, MA
Travis McMurphy, Postdoctoral Fellow
Erin Merchant, student intern, The Jackson Laboratory
Michelle Kung, summer student, undergraduate at Villanova, PA
Andrew Ouellette, Research Intern
Sarah Neuner, graduate student, Neuroscience Track, UTHSC
Lynda Wilmott, Postdoctoral Fellow, Neuroscience Track, UTHSC
Anna Zhu, M1 medical student summer research rotation, UTHSC (class of 2018)
2019 Lecturer, Development of Preclinical Models, The Jackson Laboratory; Learner type: graduate
2018 Session Chair and Lecturer “Genetics, Environment and Alzheimer’s Disease Susceptibility” at Alzheimer Association 2018 CT Dementia
Education Conference (Overall rating, 96% excellent,
80+ participants) Host: Stacy Chavis; Learner type: graduate, postdoc, faculty, clinicians
Lecturer, Neurological Disease and Aging, The Jackson Laboratory; Learner type: graduate, postdoc, faculty
Lecturer, Mammalian Genetics I & II (GENE 205A & B), Graduate School of Biomedical Science, Tufts University School of Medicine; Learner type: graduate
2017 Workshop on Neurogenetic Tools, The Jackson Laboratory; Learner type: graduate, postdoc, faculty
Lecture “Model systems for GWAS validation” Conference on Advanced Psychometric Methods in Cognitive Aging Research (Overall rating, 89%
excellent, 54 participants) Host: Paul Crane
and Dan Mungas; Learner type: graduate, postdoc, faculty
2015 Teaching Cellular Neuroscience lecture (Topic: Aging, Channels and Receptors) (6 of 6 anonymous student assessments of lecture ranked
outstanding); Learner type: graduate
Co-director of the Neuroscience Seminar Series, UTHSC; Learner type: graduate
2005 Student of Searle Center for Teaching Excellence Certification Program, Northwestern University; Learner type: undergraduate
Teaching Assistant for Dr. Teresa Horton, Science & engineering research and teaching synthesis (SERTS), Northwestern University; Learner
type: undergraduate
2002 Teaching Assistant for Dr. Nelson Spruston and Dr. Mark Segraves SERTS, Northwestern University Institute for Neuroscience; Learner type:
undergraduate
1998 Academic Tutor, Tutoring and Academic Resource Center University of Wisconsin at Milwaukee, WI; Learner type: undergraduate
Member - Planning Committee America Federation for Aging Research New Investigator in AD Meeting
Reviewer - Alzheimer’s Association International Conference® (AAIC)
Review Editor, Frontiers in Cellular Neuroscience
Ad Hoc Reviewer Trends in Genetics; Science Signaling; Cell Reports; Genome Research; Nature Neuroscience; Learning and Memory; Molecular Brain; Behavioural Brain Research; Computational and Structural Biotechnology Journal ; Experimental Biology and Medicine; Nutritional Neuroscience; Behavioral Brain Research; PLOS ONE; Biophysical Journal; Physiological Genomics
Neurodegenerative Disease Working Group, NYGC, Executive Committee Member
Winter Conference on Neural Plasticity, Steering Committee Member
New York Academy of Sciences, Member
International Behavioural and Neural Genetics Society, Member
American Association for the Advancement of Science, Member
Gerontological Society of America, Member
Society for Neuroscience, Member
Leadership and Professional Societies
2018 - Member of the Steering Committee, Winter Conference on Neural Plasticity
2019 - Executive Committee of the Neurodegenerative Disease Working Group, NYGC
2019 - Member, AMP-AD single-cell Working Group, NIA
2019 - Member, Planning Committee American Federation for Aging Research New Investigator in AD Meeting
2019 - Member, NIA Reserve and Resilience Animal Studies Workgroup
2019- Director of the JAX Center for Alzheimer’s and Dementia Research
2020- Awards Committee, International Behavioural and Neural Genetics Society
2020- Adviser and member, NIA Intervention Testing Program Access Panel