Allergic diseases, particularly asthma, represent a major public health problem in developed countries, yet there are many aspects of disease pathology that we do not yet understand. My laboratory seeks to bridge immunology, genomic research and bioinformatics to develop a deeper understanding of asthma pathogenesis. Our specific focus is on altering the function of specific cell types that control immune responses to allergens, including immune cells known as T helper cells and the epithelial cells that line the airway, allowing accurate and early diagnosis of the disease as well as the identification of novel targets for therapeutic intervention.
University College London, London, UK
Cardiff University, Wales, UK
The Jackson Laboratory for Genomic Medicine, Farmington, CT
Academic research scientist
Yale University Department of Immunology
2001, K. S. Dodgson Memorial Prize. The Best Performance by a Biochemist. Cardiff University
1998-2001, Scholarship for Excellence. University of Wales
Krishnaswamy JK, Gowthaman U, Zhang B, Mattsson J, Szeponik L, Liu D, Wu R, White T, Calabro S, Xu L, Collet MA, Yurieva M, Alsén S, Fogelstrand P, Walter A, Heath WR, Mueller SN, Yrlid U, Williams A, Eisenbarth SC. Migratory CD11b+ conventional dendritic cells induce T follicular helper cell-dependent antibody responses. Sci Immunol. 2017.
Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, Hughes C, Fonseca-Pereira D, Veiga-Fernandes H, Raj A, Kambayashi T, Brodsky IE, O'Shea JJ, Wherry EJ, Goff LA, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 2017.
Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J., The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan, Nature. 537(7619):239-243, 2016.
Calabro S, Liu D, Gallman A, Nascimento MS, Yu Z, Zhang TT, Chen P, Zhang B, Xu L, Gowthaman U, Krishnaswamy JK, Haberman AM, Williams A, Eisenbarth SC., Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity., Cell reports. 16(9):2472-85, 2016.
Williams A, Henao-Mejia J, Flavell RA. Editing the Mouse Genome Using the CRISPR-Cas9 System. Cold Spring Harb Protoc. 2016(2):pdb.top087536, 2016.
Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Prov Natl Acad Sci USA. 112(10):3056-61, 2015.
Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L5, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Nat Struct Mol Biol. 21(2):198-206, 2014.
Williams A, Lee GR, Spilianakis CG, Hwang SS, Eisenbarth SC, Flavell RA. Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression. Proc Natl Acad Sci USA. 10(17):6955-60, 2013.
Williams A, Henao-Mejia J, Harman CC, Flavell RA. miR-181 and metabolic regulation in the immune system. Cold Spring Harb Symp Quant Biol. 78:223-30, 2013.
Henao-Mejia J, Williams A, Goff LA, Staron M, Licona-Limón P, Kaech SM, Nakayama M, Rinn JL, Flavell RA. The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity. 38(5):984-97, 2013.
Bridges immunology, genomics research and bioinformatics to develop a deeper understanding of asthma pathogenesis.
A 2015 study in mice examining the developmental and behavioral differences between offspring born to asthmatic and non-asthmatic mothers...
International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.
Learn why inbred mouse models are ideal model organisms for QTL mapping of complex human traits.
By studying a new and emerging class of genomic elements, Adam Williams is turning up new ideas about how the immune system...
Studying the function of long non-coding RNAs in TH2 cells and asthma.
Leverages advanced technologies to investigate infectious diseases, human and other mammalian microbiomes, and their...