Investigates neuron loss and adult-onset neurodegeneration using forward genetics methodologies in mouse mutants.
The Ackerman Lab works to identify the genes, pathways and networks involved in the development of the central nervous system and the age-related death of neurons. Using forward genetics, we have identified genes that govern proper axonal guidance and neuronal migration. We have also discovered novel mechanisms underlying neurodegeneration using this same approach. We use a combination of genetic, cell biological and genomic approaches to investigate the molecular and cellular events that link these mutations to the corresponding phenotype.
Susan L. Ackerman is a Howard Hughes Medical Institute (HMMI) investigator, one of the top distinctions in American biomedical research.