My long-term research interests involve the analyzing high throughput sequencing data and the mathematical/computational modeling of biological systems. My academic training and industrial research experience have provided me with an excellent background in multiple disciplines including mathematics, computer science, biology and genetics. As a graduate student, I focused on the regulation of denitrification pathway in Pseudomonas aeruginosa and the regulation of iron in the context of breast cancer from a systems biology perspective and had further extrapolations into the human immune response to tuberculosis and microbiome changes due to antibiotic usage from a computational biology perspective. As a postdoctoral associate here at The Jackson Laboratory, I have been continuing to build on my previous training by moving into the field of genetics. My research has been about PR Domain Containing 9 (PRDM9), a multiple zinc finger protein that mediates the process of meiotic homologous recombination. I have been building a predictive model for PRDM9 binding sites using Affinity-Seq. My main focus is to incorporate some machine learning tools into linear regression models. I have been also doing initial analysis on PRDM9-dependent genetic interactions between cis-eQTLs and trans-eQTLs in male germ cells of BxD recombinant inbred mice.
Structural variants, or SVs, are large DNA sequences that are inserted, inverted, deleted or duplicated within genomes. Finding SVs with short-read seq and analysis methods is difficult, but a new SV identification tool, FusorSV, sets a gold standard for SV detection and analysis.
Alzheimer’s disease is still poorly understood despite its huge costs and burden. Greg Carter is working at the intersection between patient and mouse research to develop accurate disease models and develop effective therapies.
It's been 15 years since the first human genome sequence was published, and with it launched a decade and a half of human genetics and genomics inquiry that has brought amazing progress — and perhaps an equal amount of frustration. Where do we go from here?