Sarah Heuer

I joined the Kaczorowski lab as a graduate student during the spring of 2018 as part of the Tufts Ph.D. program. I am currently interested in understanding how mechanisms of neuroinflammation in the brain may be dictating why certain individuals are resilient and susceptible to Alzheimer's disease. To study this, I am using genetic, transcriptomic, and phenotypic data collected from a genetically diverse mouse model of Alzheimer's disease to investigate how microglia, the resident immune cells of the brain, are dictating resilience versus susceptibility to cognitive symptoms associated with Alzheimer's disease. Ultimately, I aim to discover and validate a microglial signature that relates to cognitive decline in Alzheimer's disease, and exploit this signature to promote resilience to Alzheimer's associated cognitive decline.

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