Samir B Amin, MBBS, Ph.D.

Postdoctoral Associate

Working in the comparative oncology field to study spontaneous development of glioma in Canis familiaris or dogs with emphasis on characterizing and comparing cancer genome and transcriptome to that in human glioma.

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About Samir B Amin, MBBS, Ph.D.

Dr. Amin received his Ph.D. in cancer computational biology from Baylor College of Medicine, Houston, TX in 01/2017. His thesis work was carried out at the UT MD Anderson Cancer Center, and was focused on understanding long non-coding RNA interactions in the context of chromatin organization using integrated analyses of publically available expression, epigenomic and chromatin interaction data. Before completing Ph.D., Dr. Amin received research training (2008-2011) in computational biology at the Dana-Farber Cancer Institute, Boston, MA where he worked on the assessment of gene expression profiling as predictive biomarker in multiple myeloma. Previously, Dr. Amin received his first professional degree in medicine, MBBS from the Medical College of Maharaja Sayajirao University of Baroda, Vadodara, India in 2005.

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Education and experience

Education:

Bachelor of Medicine, Bachelor of Surgery (MBBS) 11/1998-03/2005 Maharaja Sayajirao University of Baroda, Vadodara, Gujarat India
Ph.D. 08/2011-01/2017 Cancer Computational Biology, Graduate Program in Structural and Computational Biology & Molecular Biophysics (SCBMB), Baylor College of Medicine, Houston, TX

Experience:

Postdoctoral fellow 2017-Present Verhaak Lab at the Jackson Laboratory for Genomic Medicine, Farmington, CT
Graduate Student 2011-2016 Baylor College of Medicine and the UT MD Anderson Cancer Center, Houston, TX
Research fellow 2008-2011 Dana-Farber Cancer Institute, Boston, MA
Resident physician 2006-2007 Bhailal Amin General Hospital, Vadodara, GJ, India

Honors and accomplishments

Prof. John J. Trentin Award for Scholastic Excellence
2012 Baylor College of Medicine, Houston, TX

Selected Publications

Highlighted Abstract

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course. As part of The Cancer Genome Atlas (TCGA), we present a comprehensive molecular analysis of 333 primary prostate carcinomas. Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1). Epigenetic profiles showed substantial heterogeneity, including an IDH1 mutant subset with a methylator phenotype. Androgen receptor (AR) activity varied widely and in a subtype-specific manner, with SPOP and FOXA1 mutant tumors having the highest levels of AR-induced transcripts. 25% of the prostate cancers had a presumed actionable lesion in the PI3K or MAPK signaling pathways, and DNA repair genes were inactivated in 19%. Our analysis reveals molecular heterogeneity among primary prostate cancers, as well as potentially actionable molecular defects.

View full list of publications

Search MagazineMarch 19, 2019
Making a difference for rural cancer patients
Dr. Jens Rueter and the Maine Cancer Genomics Initiative are providing advanced genomic tools to oncology practices throughout Maine.
Research HighlightMarch 08, 2019
Long-range connectivity and gene regulation networks
A complicated three-dimensional network involving proteins and specific DNA sequences helps regulate the expression of genes. New work led by JAX’s Chia-Lin Wei shows how one protein, SOX2, plays a significant role in neural stem cells, affecting many aspects of development and function.
Search MagazineMarch 06, 2019
From tragedy, hope and closure
Doctors who treat rare pediatric cancers face an awful truth: many of their patients will die far too young.
- Cancer/Tumors
- Cancer
Press ReleaseMarch 05, 2019
3D genomics one nucleus at a time
Supported by a recent four-year, $2.3M grant from the National Institute of General Medical Sciences, Wei is looking to develop a method for chromatin interaction analysis in single nuclei, with single-molecule resolution.
- Genetic Tools
- Genetics and Genomics

Research HighlightMarch 12, 2019
A closer look at structural variants in the genome
A recent Cell paper uses long-read DNA sequencing and other advanced genomics tools and methods to shed light on genomic structural variants.
Research HighlightMarch 08, 2019
Breaking up is hard to do
New research shows that proteins work together to enable DNA double-strand breaks during meiosis.
- Reproductive Biology
- Genetics and Genomics
Search MagazineMarch 06, 2019
Finding a better way to fight childhood cancers
Ching Lau is working to find effective therapies and test them against patients’ own tumors in specially made patient derived xenotype (PDX) mice.
Research HighlightFebruary 28, 2019
Two proteins essential for layered sterocilia elongation in the inner-ear
A research team led by Basile Tarchini has found two new proteins that are essential to the correct elongation of stereocilia, tiny hair-like cellular protrusions in the inner ear.