Working in the comparative oncology field to study spontaneous development of glioma in Canis familiaris or dogs with emphasis on characterizing and comparing cancer genome and transcriptome to that in human glioma.
Dr. Amin received his Ph.D. in cancer computational biology from Baylor College of Medicine, Houston, TX in 01/2017. His thesis work was carried out at the UT MD Anderson Cancer Center, and was focused on understanding long non-coding RNA interactions in the context of chromatin organization using integrated analyses of publically available expression, epigenomic and chromatin interaction data. Before completing Ph.D., Dr. Amin received research training (2008-2011) in computational biology at the Dana-Farber Cancer Institute, Boston, MA where he worked on the assessment of gene expression profiling as predictive biomarker in multiple myeloma. Previously, Dr. Amin received his first professional degree in medicine, MBBS from the Medical College of Maharaja Sayajirao University of Baroda, Vadodara, India in 2005.
Prof. John J. Trentin Award for Scholastic Excellence
2012 Baylor College of Medicine, Houston, TX
Deribe, Y. L.; Shi, Y.; Rai, K.; Nezi, L.; Amin, S. B.; Wu, C.; Akdemir, K. C.; Mahdavi, M.; Peng, Q.; Chang, Q. E.; Hornigold, K.; Arold, S. T.; Welch, H. C. E.; Garraway, L. A.; and Chin, L. Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma. Proceedings of the National Academy of Sciences, 201513801. February 2016.
Amin SB, Yip W-K, Minvielle S, Broyl A, Li Y, Hanlon B, et al. Gene expression profile alone is inadequate in predicting complete response in multiple myeloma. Leukemia. 2014;28:2229–34.
Yan Z, Shah PK, Amin SB, Samur MK, Huang N, Wang X, et al. Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res. 2012;40:e135.
Tian Z, Zhao J-J, Tai Y-T, Amin SB, Hu Y, Berger AJ, et al. Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells. Blood. 2012;120:3958–67.
Fulciniti M, Amin S, Nanjappa P, Rodig S, Prabhala R, Li C, et al. Significant biological role of sp1 transactivation in multiple myeloma. Clin. Cancer Res. 2011;17:6500–9.
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