Dr. Zeeshan has a PhD in Bioinformatics and her research is aimed at understanding highly aggressive cancers. Associated with “The Cancer Isoform Program” in deciphering the basis of cancer with in-depth isoformic characterization of cancer cells leveraging modern genomic tools with the aim to develop novel therapeutic strategies for precision medicine. Her work is focused on transcriptome profiling of high-grade cancers such as triple negative breast cancer and melanoma that are characterized by a high level of genetic heterogeneity that are not responsive to targeted interventions.
As immuno-oncology takes center stage in the battle against cancer, the need for biomarkers has become even more acute. Applying immunoinformatics to studying cancer biology, her work has led her to identify alternative-splicing alterations in cancer and develop a quantitative, in-depth mechanistic understanding of molecular communication governing the dynamics of the tumorigenesis. Identification of novel signatures at various stages and with different treatments will serve as promising candidates for novel therapeutics as well as biomarkers for precise treatment and management.