I hold a PhD in bioinformatics and Computational Biology with a minor in Statistics. For my dissertation work, I established the essential bioinformatics infrastructure in functional genomics studies using metabolomics as a systems biology tool. I have utilized Mass spectrometry for developing Human Embryonic (hES) and Induced Pluripotent Stem (IPS) cells based assays for drug toxicity screening, for developing a test for biomarkers of autism using patient’s blood and for detecting bio-markers for Escherichia coli O157 infection in cattle from blood samples. I am currently developing a computational metabolomics platform to analyze and visualize mass spectrometry based metabolomics data in JAX. In addition to metabolomics, I am gaining experience in next generation sequencing technologies and cloud computing by developing a tumor neoepitope prediction pipeline for personalized medicine. I am also participating in team of computational and single cell genomics scientists in developing the JAX infrastructure for mass cytometry data analysis.
PlantMetabolomics.org (PM) is a web portal and database for exploring, visualizing, and downloading plant metabolomics data. Widespread public access to well-annotated metabolomics datasets is essential for establishing metabolomics as a functional genomics tool. PM integrates metabolomics data generated from different analytical platforms from multiple laboratories along with the key visualization tools such as ratio and error plots. Visualization tools can quickly show how one condition compares to another and which analytical platforms show the largest changes. The database tries to capture a complete annotation of the experiment metadata along with the metabolite abundance databased on the evolving Metabolomics Standards Initiative. PM can be used as a platform for deriving hypotheses by enabling metabolomic comparisons between genetically unique Arabidopsis (Arabidopsis thaliana) populations subjected to different environmental conditions. Each metabolite is linked to relevant experimental data and information from various annotation databases. The portal also provides detailed protocols and tutorials on conducting plant metabolomics experiments to promote metabolomics in the community. PM currently houses Arabidopsis metabolomics data generated by a consortium of laboratories utilizing metabolomics to help elucidate the functions of uncharacterized genes. PM is publicly available at http://www.plantmetabolomics.org.