Jeremy Racine, Ph.D.
Associate Research Scientist
Investigating type 1 diabetes and the development of therapies using mouse models of the disease.
My research involves the development of therapies for treating type 1 diabetes in a humanized version of the NOD mouse. Using NOD mice in which the mouse MHC class I has been replaced with a human variant linked to type 1 diabetes development, I am studying how several therapies can tolerize autoreactive CD8+ T cells selected on the human HLA. The first project revolves around using hematopoietic stem cell transplantation and induction of mixed chimerism to determine how protective MHC can tolerize autoreactive CD8+ T cells. A second project revolves around peptide-microsphere conjugates and how dosing pre-diabetic humanized-NOD mice with diabetogenic peptides can prevent diabetes development, and the mechanisms by which autoreactive CD8+ T cells are tolerized by these peptide-microsphere conjugates. A final side project/collaboration involves dissecting the mechanisms by which IFNϒ can act as an inhibitory cytokine for autoreactive CD8+ T cell expansion.
Grants, honors and accomplishments
2014-Current JAX Postdoctoral Scholar
2012 Rachmiel Levine Scientific Communications Award - 1st place Scientific Talk - “Reversal of T and B Cell Autoimmunity in Type 1 Diabetes via Induction of Mixed Chimerism”. Presentation at City of Hope Beckman Research Institute RSO Advance. April 30 2012. Lake Arrowhead, CA. 2008 Helen and Morgan Chu Graduate Student Fellowship
2007-2008 H.N. and Frances C. Berger Fellow
2012 Selected as Irell & Manella Nominee for Harold M. Weintraub Graduate Student Awards
2010 Selected as Irell & Manella Nominee for Lindau Nobel Laureate Meetings
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Research HighlightApril 16, 2024Developing immune therapy without immune toxicity
A team led by David Serreze presents a mouse model for studying severe immune checkpoint inhibition-based damage to heart and skeletal muscle, providing an important resource for maximizing the benefits and minimizing the side effects of vital immunotherapies. -
Research HighlightSeptember 26, 2023Unveiling the link between Type 1 diabetes and autoimmune neuropathies
Jeremy Racine, Ph.D., develops new mouse model to further explore the connection between Type 1 diabetes and neuritis. -
Search MagazineNovember 19, 2014Five Questions with Jeremy Racine
Jeremy Racine, Ph.D., is currently researching treatments to prevent type 1 diabetes in “humanized” NOD mice.
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Press ReleaseDecember 19, 2023JAX's 2023 achievements
JAX is celebrating important research breakthroughs, new faculty and leadership appointments, and crucial advancements in legislation. -
Press ReleaseJune 01, 2017How to block type 1 diabetes
JAX researchers, collaborators block B-cell AID, prevent diabetes in non-obese diabetic mice