Nicholas Tolman

Ph.D. Student

Determining the molecular mechanisms underlying intraocular pressure elevation in glaucoma


Bar Harbor, ME





I research the molecular mechanisms underlying the function of aqueous humor outflow structures in the limbal region of the eye. Aqueous humor outflow structures, which include the trabecular meshwork and Schlemm’s canal, are critical to maintaining intraocular pressure homeostasis. Elevated intraocular pressure is a major risk factor in Glaucoma, a leading cause of blindness worldwide. Using mouse models, I am investigating the genes and pathways of the aqueous humor outflow structures involved in intraocular pressure regulation. The goal of my work is to uncover molecular targets to lower intraocular pressure in Glaucoma patients.