Allogeneic tumors are eventually rejected by adaptive immune responses, however, little is known about how allogeneic tumors are eradicated at the early stage of tumor development. In the study, we found that NKG2DL low expressing cancer cells were developed into palpable allogeneic tumors in mice within a week after the inoculation, while NKG2DL high expressing cancer cells failed to. Artificially up-regulating NKG2DL on cancer cells with low level expressed NKG2DL by a CpG ODN resulted in the retardation and rejection of the allogeneic tumors at the early stage. The contribution of up-regulated NKG2DL to the early rejection was further confirmed by the results that the development of allogeneic tumors from cancer cells transfected with NKG2DL genes was significantly inhibited in mice at the early stage.
9/2011 - 12/2016
Ph.D. Cancer Immunotherapy (mentor: Yongli Yu, Ph.D & Liying Wang, Ph.D.)
Department of Immunology&Molecular Biology
Jilin University, China
9/2005 - 6/2010
Bachelor, clinical laboratory medicine
Hebei North University, China
Xu Y, Liu J, Hua L, Xiao Y, Tian Y, Guo S, Zhang X, He C, Wang L, Yu Y. An immune regulatory CCT repeat containing oligodeoxynucleotide capable of causing hair loss in male mice. Hum Exp Toxicol. 2016 Jan 12.
Hua L, Fang M, Dong B, Guo S, Cui C, Liu J, Yao Y, Xiao Y, Li X, Ren Y, Meng X, Hao X, Zhao P, Song Y, Wang L, Yu Y. Attribution of NKG2DL to the inhibition of early stage allogeneic tumors in mice. Oncotarget. 2016 Jul 19.
Ren Y, Hua L, Meng X, Xiao Y, Hao X, Guo S, Zhao P, Wang L, Dong B, Yu Y, Wang L.Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli. Mediators Inflamm. 2016;2016:3296307.
Fang M, Diao W, Dong B, Wei H, Liu J, Hua L, Zhang M, Guo S., et al. Detection of theAssembly and Disassembly of PCV2b Virus-Like Particles Using Fluorescence Spectroscopy Analysis. Intervirology. 2015; 58(5):318-23.
Guo S, Li X, Wan M, Hua L, Xiao Y, Dong B, Liu J, Diao W, Yu Y, Wang L. Impact of Fighting on Antibody Response to Hepatitis B Virus Vaccine in Mice. Viral Immunol. 2015 Sep 29.
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