Kin-hoe Chow, Ph.D.

Postdoctoral Fellow

Bar Harbor, ME

Studying the role of a tumor-related gene in glioblastoma vasculature.

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About Kin-hoe Chow, Ph.D.

My research focuses on understanding the disease etiology of brain cancers. Specifically, I am studying the role of a tumor invasion and metastasis related gene, S100a4, in driving the development and maintenance of tumor vasculature in glioblastoma. Upon surveying patient-derived glioma tumor tissue arrays, I have observed that glioma cells in the vicinity of tumor vasculature frequently express high level of S100a4, suggesting a vasculature related role of S100a4 in glioma tumorigenesis. Using mouse glioma allograft model, I found that depletion of S100a4 resulted in drastic reduction of tumor size and volume, as well as tumor vasculature. Using a mouse model, tumor allografts and xenografts, as well as various in vitro assays performed using patient-derived glioma stem cell cultures, I am currently dissecting the molecular mechanism of S100a4 in mediating the development/maintenance of tumor vasculature.

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Grants, awards and accomplishments

Maine Cancer Foundation Pilot Grant, Assessing Therapeutic Potential of a New Drug ICG-001 in Glioblastoma. 2013-2014 ($50,000)

American Heart Association Predoctoral Fellowship, 2006-2008 ($43,000/2yrs)

Poster Award, Annual Bioscience Symposium and Don Summers Memorial Lecture, University of Utah 2007

F1000 Prime nomination as top article in biology and medicine of the publication: Courcelle J, Donaldson JR, Chow KH & Courcelle CT (2003) DNA damage-induced replication fork regression and processing in Escherichia coli. Science 299: 1064-1067. http://f1000.com/prime/1011878

Research Assistant of the Year, Master Level, Mississippi State University 2004

Certificate of Academic Achievement from The Holmes Cultural Diversity Center, Mississippi State University, 2001-2002

Mississippi State University – INTI College Malaysia Achievement Scholarship 2000-2002

The Search Magazine Article September 18, 2017
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eNews June 08, 2016
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Blog Post January 02, 2013
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