Bar Harbor, ME
Studying the role of a tumor-related gene in glioblastoma vasculature.
My research focuses on understanding the disease etiology of brain cancers. Specifically, I am studying the role of a tumor invasion and metastasis related gene, S100a4, in driving the development and maintenance of tumor vasculature in glioblastoma. Upon surveying patient-derived glioma tumor tissue arrays, I have observed that glioma cells in the vicinity of tumor vasculature frequently express high level of S100a4, suggesting a vasculature related role of S100a4 in glioma tumorigenesis. Using mouse glioma allograft model, I found that depletion of S100a4 resulted in drastic reduction of tumor size and volume, as well as tumor vasculature. Using a mouse model, tumor allografts and xenografts, as well as various in vitro assays performed using patient-derived glioma stem cell cultures, I am currently dissecting the molecular mechanism of S100a4 in mediating the development/maintenance of tumor vasculature.
Maine Cancer Foundation Pilot Grant, Assessing Therapeutic Potential of a New Drug ICG-001 in Glioblastoma. 2013-2014 ($50,000)
American Heart Association Predoctoral Fellowship, 2006-2008 ($43,000/2yrs)
Poster Award, Annual Bioscience Symposium and Don Summers Memorial Lecture, University of Utah 2007
F1000 Prime nomination as top article in biology and medicine of the publication: Courcelle J, Donaldson JR, Chow KH & Courcelle CT (2003) DNA damage-induced replication fork regression and processing in Escherichia coli. Science 299: 1064-1067. http://f1000.com/prime/1011878
Research Assistant of the Year, Master Level, Mississippi State University 2004
Certificate of Academic Achievement from The Holmes Cultural Diversity Center, Mississippi State University, 2001-2002
Mississippi State University – INTI College Malaysia Achievement Scholarship 2000-2002
This workshop provides training in the use of genetically defined laboratory mice as tools for asking questions about gene function and the...
Considerations for interpreting and using results from direct-to-consumer genetic testing for hereditary breast and ovarian...
Professor Roel Verhaak is analyzing genomic data sets from human and canine brain tumors to solve the mystery of why cancer...
The latest developments in cancer research and their translation to oncology practice offer truly exciting potential for better therapies...
New research is providing a better understanding of the processes underlying cell-to-cell differences within glioblastoma tumors — a...
Brain tumors, sequencing, computational biology.
Cancer is a heterogeneous collection of diseases characterized by uncontrolled cell growth and spread to distant organs. In this series, we...
New JAX program is helping oncologists quickly find the most effective cancer treatments for each of their patients.
The members of the American Association for Cancer Research have elected Jackson Laboratory President and CEO Edison T. Liu,...
First global online catalog of Patient-Derived Xenograft models helps cancer researchers save valuable time.
New 3D bioprinting technique creates a platform for precision immunotherapy study.
Aged or pre-conditioned mice provided as study-ready models for your research.
Establishing PDX cohorts from frozen samples can extend drug efficacy studies 6-12 weeks or more. The inventoried PDX Live tumor program at...
We are committed to providing academic PIs the most innovative pre-clinical models and services to delineate the mechanisms underlying...
NSG™ and NSG™-SGM3 mice engrafted with allogeneic human tumors represent a valuable preclinical testing platform for immuno-oncology. Here...
We are committed to providing academic PIs the most innovative pre-clinical models and services to delineate the mechanisms underlying...
We use cookies to give you the best online experience.
By using our website you agree to our use of cookies in accordance with our cookie policy.