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Jian Wei, Ph.D.

Postdoctoral Associate

Studies the impact of metabolic pathways and environments on function of immune cells during homeostasis and diseases.

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About Jian Wei, Ph.D.

My background is in lipid metabolism with a focus on exploring genetic reasons and mechanisms of cholesterol homeostasis and metabolic diseases. Currently I have a keen interest in metabolic regulation of immune system. Besides providing energy and fundamental substrates for survival and growth, metabolic pathways and metabolites control fate decision, differentiation, and effector functions of immune cells. We are investigating the role of metabolic evens within immune cells and elucidating how this impacts immune response outcome. In addition, our study lies at how conditions within the tumor microenvironment shape the metabolism and function of immune cells, thereby suppressing immune response. Ultimately, we aim to develop genetic and pharmacological approaches manipulating immune cell metabolism to improve treatment of cancer and immunological diseases.

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Education and experience

Education

Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Ph.D., Biochemistry and Molecular Biology
Adv: Dr. Bao-Liang Song
2009-2015

Shandong University
B.A., biology
2005-2009

Experience

The Jackson Laboratory
Postdoctoral associate
2018-present

Wuhan University
Postdoctoral associate
2015-2017

Selected Publications

Research HighlightJune 21, 2018
Finding the genes controlling ovarian reserve could hold key to better female fertility care
Jackson Laboratory Assistant Professor Ewelina Bolcun-Filas, Ph.D., is looking at how multiple genetic factors regulating oocyte development determine the differences in each woman’s ovarian reserve.
Tech CornerMay 04, 2018
What's new in cancer research?
The field of cancer immunotherapy research is extremely exciting, yet still somewhat mysterious, as researchers grapple with the fine-tuning of patient response.
- Cancer/Tumors
- Cancer
Search MagazineApril 27, 2018
Finding precise cures for cancer
At JAX's new speaker event series, JAXtaposition, two scientific leaders shared how the Maine Cancer Genomics Initiative and JAX’s cutting-edge genomic testing is giving physicians access to the most advanced precision cancer care for their patients.
- Cancer/Tumors
- Cancer
Tech CornerApril 10, 2018
Cancer and its immune environment bioprinted and reproduced live and in 3D
New 3D bioprinting technique creates a platform for precision immunotherapy study.

Research HighlightJune 11, 2018
Measuring tumor heterogeneity for better, evolution-based cancer treatment strategies
JAX Associate Professor Jeffrey Chuang, Ph.D., has been awarded a five-year grant totaling $2,650,484 from the National Cancer Institute for research that could pave the way for the first evolution-based approaches to cancer treatment.
- Cancer/Tumors
- Cancer
Press ReleaseApril 30, 2018
Detecting human genome structural variation with long read sequencing
A research team led by Chia-lin Wei is using technology to more easily detect and classify important types of difficult-to-find genomic alterations, known as structural variants.
- Genetic Tools
- Genetics and Genomics
Press ReleaseApril 23, 2018
The role of extra DNA in cancer evolution and therapy resistance
New research is providing a better understanding of the processes underlying cell-to-cell differences within glioblastoma tumors — a crucial finding because these differences contribute to therapy resistance.
- Cancer/Tumors
- Cancer
Tech CornerApril 05, 2018
Finding the signal in the noise
GeneWeaver is a powerful web-based software system that combines a genomics data repository with powerful analysis tools.
- Genetic Tools
- Genetics and Genomics