Jian Wei

Postdoctoral Associate

Studies the impact of metabolic pathways and environments on function of immune cells during homeostasis and diseases.

About Jian Wei, Ph.D.

My background is in lipid metabolism with a focus on exploring genetic reasons and mechanisms of cholesterol homeostasis and metabolic diseases. Currently I have a keen interest in metabolic regulation of immune system. Besides providing energy and fundamental substrates for survival and growth, metabolic pathways and metabolites control fate decision, differentiation, and effector functions of immune cells. We are investigating the role of metabolic evens within immune cells and elucidating how this impacts immune response outcome. In addition, our study lies at how conditions within the tumor microenvironment shape the metabolism and function of immune cells, thereby suppressing immune response. Ultimately, we aim to develop genetic and pharmacological approaches manipulating immune cell metabolism to improve treatment of cancer and immunological diseases.

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Education and experience

Education

Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Ph.D., Biochemistry and Molecular Biology
Adv: Dr. Bao-Liang Song
2009-2015

Shandong University
B.A., biology
2005-2009

Experience

The Jackson Laboratory
Postdoctoral associate
2018-present

Wuhan University
Postdoctoral associate
2015-2017

Research HighlightDecember 11, 2018
The unexpected advantages of outbred mice in research
Recently developed outbred mouse populations, such as the diversity outbred (DO) mice at The Jackson Laboratory (JAX), have created research options that parallel or even exceed human genetic diversity. Research with DO mice offers a full range of genetic diversity, and therefore more generalizability of responses across populations.
Blog PostNovember 27, 2018
Efficient and effective methods to use family history data for risk assessment
As 1 in 10 people are at increased risk for cancer, but often go undetected, knowing who these people are can lead to personalized management and better health outcomes.
- Cancer/Tumors
- Cancer
Blog PostOctober 31, 2018
Can we do a better job of preserving fertility and ovarian function for young breast cancer survivors?
Young women with a new cancer diagnosis are faced with a number of challenges. These patients (and their providers) are often anxious to begin treatment right away. The problem is that many young women haven’t started or completed their families at the time of their diagnosis.
Research HighlightOctober 11, 2018
Stuck in a dangerous cycle
Paper provides important insight for B-cell lymphomagenesis from mouse models to human disease.

Blog PostDecember 11, 2018
Nesting dolls and Narnia
If movies were true to real life, matryoshka dolls would provide a good analogy for genomics research.
Press ReleaseNovember 13, 2018
V Foundation funds JAX cancer research for third straight year
Armed with new funding from the V Foundation, Olga Anczuków-Camarda is uncovering genetic changes in the breast, paving the road to early cancer detection and prevention.
Press ReleaseOctober 24, 2018
Data provides new hope for pediatric brain tumor patients
Using computer models, researchers have identified a potential new therapy that would reduce the long-term side effects of radiation therapy in pediatric brain cancer patients.
Tech CornerOctober 11, 2018
Precision medicine and making sense of data
JAX professor calls for concerted effort to align data across patients and systems with comparable and consistent formats and contextual meaning.

Jian Wei, Ph.D.

Postdoctoral Associate

About Jian Wei, Ph.D.

Education

Experience

Selected Publications