Jian Wei

Postdoctoral Associate

Studies the impact of metabolic pathways and environments on function of immune cells during homeostasis and diseases.

About Jian Wei, Ph.D.

My background is in lipid metabolism with a focus on exploring genetic reasons and mechanisms of cholesterol homeostasis and metabolic diseases. Currently I have a keen interest in metabolic regulation of immune system. Besides providing energy and fundamental substrates for survival and growth, metabolic pathways and metabolites control fate decision, differentiation, and effector functions of immune cells. We are investigating the role of metabolic evens within immune cells and elucidating how this impacts immune response outcome. In addition, our study lies at how conditions within the tumor microenvironment shape the metabolism and function of immune cells, thereby suppressing immune response. Ultimately, we aim to develop genetic and pharmacological approaches manipulating immune cell metabolism to improve treatment of cancer and immunological diseases.

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Education and experience

Education

Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Ph.D., Biochemistry and Molecular Biology
Adv: Dr. Bao-Liang Song
2009-2015

Shandong University
B.A., biology
2005-2009

Experience

The Jackson Laboratory
Postdoctoral associate
2018-present

Wuhan University
Postdoctoral associate
2015-2017

Press ReleaseSeptember 25, 2018
Brain cancer’s lethal differences: tracking extra DNA
Postdoctoral Associate Eunhee Yi has been awarded a $100,000 fellowship from the American Brain Tumor Association to discover how glioblastoma becomes so aggressive.
Research HighlightSeptember 13, 2018
Distinguishing the helpful from the harmful in the human microbiome
New JAX research offers insight into how our immune cells are able to tell the difference between helpful bacterial strains and potentially inflammatory or pathogenic strains.
Search MagazineSeptember 11, 2018
Non-coding DNA is not junk DNA
Assistant Professor Christine Beck, Ph.D., is uncovering how recurring sequences in our genomes might shed light on genome stability, as well as diseases like cancer.
Search MagazineAugust 14, 2018
Understanding our inheritance
To find out more about the complexities of inheritance, JAX spoke with author and New York Times columnist Carl Zimmer, who frequently writes about genetics and evolution.

Press ReleaseSeptember 21, 2018
New way to target advanced breast cancers
New research shows that a cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target.
Research HighlightSeptember 11, 2018
Exploring zinc finger proteins
The National Institute of General Medical Sciences has awarded Petko Petkov a four-year grant totaling $1,385,337 to exploit the new methods he has developed to profile and investigate zinc finger proteins and their binding sites.
Press ReleaseSeptember 05, 2018
A better combination therapy for leukemias
A new approach to treating some leukemias could deliver a one-two punch to the cancer cells without harming normal tissue.
Press ReleaseAugust 01, 2018
$2M NIH Grant to Study Genetic Mechanisms of Inherited Heart Muscle Disorders
Travis Hinson, M.D., has received more than $2 million from the National Institutes of Health National Heart, Lung, and Blood Institute to study the mechanisms responsible for a serious and often fatal heart condition.
- Cardiovascular
- Genetics and Genomics

Jian Wei, Ph.D.

Postdoctoral Associate

About Jian Wei, Ph.D.

Education

Experience

Selected Publications