Studies the impact of metabolic pathways and environments on function of immune cells during homeostasis and diseases.
My background is in lipid metabolism with a focus on exploring genetic reasons and mechanisms of cholesterol homeostasis and metabolic diseases. Currently I have a keen interest in metabolic regulation of immune system. Besides providing energy and fundamental substrates for survival and growth, metabolic pathways and metabolites control fate decision, differentiation, and effector functions of immune cells. We are investigating the role of metabolic evens within immune cells and elucidating how this impacts immune response outcome. In addition, our study lies at how conditions within the tumor microenvironment shape the metabolism and function of immune cells, thereby suppressing immune response. Ultimately, we aim to develop genetic and pharmacological approaches manipulating immune cell metabolism to improve treatment of cancer and immunological diseases.
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Ph.D., Biochemistry and Molecular Biology
Adv: Dr. Bao-Liang Song
The Jackson Laboratory