Determining genetic modifiers/drivers in brain myeloid cells that impact Alzheimer's disease progression
Brain myeloid cell-mediated neuroinflammation plays a key role in genetic susceptibility and development of dementias, particularly Alzheimer’s disease (AD), but the precise mechanisms are not known. I employ genetically diverse mouse models of AD to mimic the vast amount of genetic variation seen in the human patients. I apply the cutting-edge single-cell RNA sequencing technology together with biochemical and behavioral assays to identify genetic modifiers/drivers in brain myeloid cells that impact AD progression. The ultimate goal of my study is to identify novel therapeutic targets for AD.