My long-term research interests involve understanding the complex mechanisms underlying transcriptional regulation of human disease. As an undergraduate I worked under the guidance of Yves Brun, Ph.D., aiding in the discovery of genes essential for the adherence of several species of stalked bacteria. I performed my dissertation research in the laboratory of Klaus Kaestner, Ph.D., studying how the DNA methyltransferases Dnmt1 and Dnmt3b influence mouse intestinal development and cancer. My research demonstrated that Dnmt1 is required for mouse intestinal development, but is not required for survival of the mature adult intestinal epithelium. We also demonstrated that the de novo methyltransferase enzyme Dnmt3b compensates for the loss of maintenance methyltransferase Dnmt1 in the adult intestine.
As a postdoc in the laboratory of Adam Williams, Ph.D., I am studying the mechanisms underlying autosomal recessive DOCK8 (Dedicator Of Cytokinesis 8) immunodeficiency. Loss of DOCK8 in human patients results in Hyper IgE Syndrome, which is characterized by severe allergies and increased susceptibility to infections. We are employing a DOCK8-null mouse model to analyze the role of DOCK8 in T cell function. My research will broaden our understanding of allergic disease, and identify new mechanisms that may be utilized in therapeutic research.
The Jackson Laboratory
Adv: Adam Williams, Ph.D.
University of Pennsylvania Perelman School of Medicine
Ph.D., Cell & Molecular Biology
Adv: Klaus H. Kaestner, Ph.D.
Undergrad Research Advisor: Yves V. Brun, Ph.D.
Sheaffer KL*, Elliott EN*, Kaestner KH. DNA hypomethylation contributes to genomic instability and intestinal cancer initiation. Cancer Prev Res (Phila) 9(7):534-46, 2015.
Sheaffer KL, Kim R, Aoki R, Elliott EN, Schug J, Burger L, Schübeler D, Kaestner KH. DNA methylation is required for the control of stem cell differentiation in the small intestine. Genes Dev 28(6):652-64, 2014.
Elliott EN, Sheaffer KL, Schug J, Stappenbeck TS, Kaestner KH. Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Development 142(12):2163-72, 2015.
Elliott EN*, Sheaffer KL*, Kaestner KH. The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium. eLife.12795, 2016.
Kotzin KJ, Spencer SP, McCright SJ, Kumar DBU, Collet MC, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CCD, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. The long-noncoding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 537(7619):239-43, 2016.
A 2015 study in mice examining the developmental and behavioral differences between offspring born to asthmatic and non-asthmatic mothers...
Learn why inbred mouse models are ideal model organisms for QTL mapping of complex human traits.
Bridges immunology, genomics research and bioinformatics to develop a deeper understanding of asthma pathogenesis.
Conducts research that bridges immunology, genomics research and bioinformatics to develop a deeper understanding of asthma...
International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.