Diana Cadena-Castaneda, Ph.D.

Postdoctoral Associate

I study the implication of myeloid cells, particularly antigen-presenting cells (APCs), in antiviral immune response.

My work is focused on implementing in vitro models in order to explore the molecular/cellular mechanisms of the immune system against respiratory virus. To this end, we are using organoids to expand lung progenitor cells from primary lung tissues to subsequently derive air-liquid interface (ALI) cultures. ALI cultures are then infected with influenza or SARS-CoV-2 in the presence or absence of immune cells. Responses to infection of both epithelial cells and immune cells are analyzed by flow cytometry, immunofluorescence and RNA-Seq. Those approaches will enable us to determine molecular mechanisms underlying alterations in the innate immune cells at epithelial barriers.

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