Researching the ex vivo organotypic slice culture method as a means to bridge the gap between cell culture and animal model studies
I am interested in developing model systems and identifying mechanisms responsible for treatment response and resistance in cancer. My previous research was focused on identifying mechanisms of drug resistance in breast cancer, specifically the role of cancer stem populations and identifying alternative agents that can be combined with present clinical strategies to improve clinical outcome of patients. At present, as a Postdoctoral Associate at the Jackson Laboratory, my research includes developing the ex vivo organotypic slice culture method using patient-derived xenografts tumors (PDX) as a means to bridge the gap between cell culture and animal model studies. I will also use the ex vivo system to dissect mechanisms of therapy response and genetic signatures associated with therapy resistance in brain cancer and triple-negative breast cancer.