Psoriasis Mouse Model Resource
Inducible models
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000651 | BALB/cJ | inducible (imiquimod) | van der Fits et al. 2009 |
| 001803 | CBySmn.CB17-Prkdcscid/J | inducible (adoptive T cell transfer) | Davenport et al. 2002 |
JAX® Mice for psoriasis research
| Gene | Gene/protein function and details | Reference |
|---|---|---|
| Cd4, Cd4 antigen | Glycoprotein expressed on the surface of helper T lymphocytes and other immune cells. CD4 functions to initiate or augment the early phase of T cell activation. |
Watabe et al. 2007 |
| Cd80, Cd80 antigen | Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG. |
Gottlieb et al. 2002 |
| Cd86, Cd86 antigen | Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2. |
Abrams et al. 2000 |
| Fas, TNF receptor superfamily member 6 | TNF-receptor superfamily, death domain containing member. Plays a central role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of diseases of the immune system. Also known as CD95 and TNFR6. |
Gilhar et al. 2006 |
| Ifng, interferon gamma | Cytokine critical for innate and adaptive immunity. Aberrant expression is associated with a number of autoinflammatory and autoimmune diseases. |
Bockelmann et al. 2005 |
| Il2ra, interleukin 2 receptor, alpha chain | The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25. |
Krueger et al. 2000 |
| Il4, interleukin 4 | Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity. |
Ghoreschi et al. 2003 |
| Il10, interleukin 10 | An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation. |
Asadullah et al. 2004 |
| Il12a, interleukin 12a | Cytokine which has a number of biological activities including T cell-independent induction of interferon (IFN)-gamma. Important for the differentiation of both Th1 and Th2 cells. |
Cheng et al. 2001 |
| Il12b, interleukin 12b | IL12 p40 subunit. Cytokine expressed by activated macrophages and important for Th1 cell development, regulation and memory. |
Nair et al. 2008 |
| Rela, v-rel reticuloendotheliosis viral oncogene homolog A | NF-kappa-B or p65 is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. |
Nair et al. 2009 |
| Pomc, pro-opiomelanocortin-alpha | Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. |
Karanikas et al. 2007 |
| Pparg, peroxisome proliferator activated receptor gamma | Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases. |
Kuenzli and Saurat. 2003 |
| Ptgs2, prostaglandin-endoperoxide synthase 2 | Participates in synthesizing prostanoids involved in pain and inflammation. Also known as cyclooxygenase-2 (COX2). |
Koczan et al. 2005 |
| Tnf, tumor necrosis factor | Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types. |
Schottelius et al. 2004 |
| Vdr, vitamin D receptor | Nuclear receptor capable of transactivating vitamin-D responsive genes. |
Kong et al. 2006 |
| At this time there are no JAX® Mice strains available for the following symbols: H2-Eb1 and Il23a. | ||