Multiple Sclerosis Mouse Model Resource

Inducible Models

Stock No. Strain Name Disease development Reference
000664 C57BL/6J inducible (MOG peptide) Mendel et al. 1995
000686 SJL/J inducible (proteolipid protein) Duzhak et al. 2003
001026 BALB/cByJ  inducible Teuscher et al. 1987
100008 NZBWF1/J inducible (MBP) Zamvil et al. 1994
000457 B10.RIII-H2r H2-T18b/(71NS)SnJ inducible (MBP) Zhao et al. 1993
JAX® Mice for multiple sclerosis research

Gene Gene/protein function and details Reference
Ccl2, chemokine (C-C motif) ligand 2 Small cytokine belonging to the CC chemokine family; also known as monocyte chemotactic protein-1 (MCP-1). Recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection.

Dogan et al. 2008

Cd40, CD40 antigen A costimulatory protein found on antigen presenting cells and is required for their activation

Wiesemann et al. 2008

Cd80, Cd80 antigen Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG.

Racke et al. 2000

Cd86, Cd86 antigen Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2.

Marckmann et al. 2004

Ciita, class II transactivator Positive regulator of Class II major histocompatibility complex (MHC) gene transcription, functioning through activation of the transcription factor RFX5. Considered the "master control factor", needed for expression of MHC Class II genes.

Swanberg et al. 2005

Fas, TNF receptor superfamily member 6 TNF-receptor superfamily, death domain containing member. Plays a central role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of diseases of the immune system. Also known as CD95 and TNFR6.

Lopatinskaya et al. 2006

Ifng, interferon gamma Cytokine critical for innate and adaptive immunity. Aberrant expression is associated with a number of autoinflammatory and autoimmune diseases.

Schrijver et al. 2004

Il2ra, interleukin 2 receptor, alpha chain The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25.

van Boxel-Dezaire et al. 2001

Il4, interleukin 4 Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity.

Ponomarev et al. 2007

Il7, interleukin 7 Cytokine important for B and T cell development. Plays an essential role in lymphoid cell survival.

Kremlev et al. 2008

Il10, interleukin 10 An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation.  Dressel et al. 2006
Il12a, interleukin 12a Cytokine which has a number of biological activities including T cell-independent induction of interferon (IFN)-gamma. Important for the differentiation of both Th1 and Th2 cells.

Gran et al. 2002

Myd88, myeloid differentiation primary response gene 88 Adapter protein involved in Toll-like receptor and interleukin 1 receptor signaling pathways within the innate immune response. Activates the transcription factor NF-kappa-B.

Marta et al. 2009

Nos2, nitric oxide synthase 2, inducible Encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines.

Dogan et al. 2008

Pomc, pro-opiomelanocortin-alpha Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.

Then Bergh et al. 1999

Pparg, peroxisome proliferator activated receptor gamma Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases.

Aktas et al. 2007

Ptgs2, prostaglandin-endoperoxide synthase 2 Participates in synthesizing prostanoids involved in pain and inflammation. Also known as cyclooxygenase-2 (COX2).

Rose et al. 2004

Tlr2, toll-like receptor 2 Surface receptor present on multiple immune cells. Binds diverse pathogenic substances and initiates innate immune responses. Also known as CD282 and Ly105.

Buckland et al. 2008

Tlr4, toll-like receptor 4 Surface receptor for lipopolysaccharides from Gram-negative bacteria. Receptor engagement initiates innate immune response.

Marta et al. 2008

Tnf, tumor necrosis factor Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types.

Dogan et al. 2008

Vdr, vitamin D receptor Nuclear receptor capable of transactivating vitamin-D responsive genes.

Correale et al. 2009