Inflammatory Bowel Disease Mouse Model Resource
Inducible models
|
Stock No. |
Strain Name |
Disease development |
Reference |
|---|---|---|---|
|
C57BL/6J |
inducible (DSS) |
||
|
BALB/cJ |
inducible (TNBS) |
||
|
CBySmn.CB17-Prkdcscid/J |
inducible (adoptive T cell transfer) |
||
|
NOD/ShiLtJ |
inducible (DSS) |
JAX® Mice for IBD research
| Gene | Gene/protein function and details | Reference |
|---|---|---|
| Cd4, Cd4 antigen | Glycoprotein expressed on the surface of helper T lymphocytes and other immune cells. CD4 functions to initiate or augment the early phase of T cell activation. |
Westendorf et al. 2005 |
| Cd40, CD40 antigen | A costimulatory protein found on antigen presenting cells and is required for their activation |
Danese et al. 2007 |
| Cd40lg, CD40 ligand | Protein expressed on both CD4+ and CD8+ T cells that aids in stimulating B cells in the immune response. |
Danese et al. 2007 |
| Cd80, Cd80 antigen | Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG. |
Eri et al. 2008 |
| Cd86, Cd86 antigen | Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2. |
Ebert et al. 2005 |
| Fas, TNF receptor superfamily member 6 | TNF-receptor superfamily, death domain containing member. Plays a central role in the physiological regulation of programmed cell death and has been implicated in the pathogenesis of diseases of the immune system. Also known as CD95 and TNFR6. |
Yukawa et al. 2002 |
| Il2ra, interleukin 2 receptor, alpha chain | The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25. |
Holmén et al. 2007 |
| Il4, interleukin 4 | Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity. |
Griga et al. 2000 |
| Il6, interleukin 6 | An interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. |
Atreya and Neurath. 2005 |
| Il7, interleukin 7 | Cytokine important for B and T cell development. Plays an essential role in lymphoid cell survival. |
Totsuka et al. 2007 |
| Il10, interleukin 10 | An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation. |
Akhiani et al. 2005 |
| Il12a, interleukin 12a | Cytokine which has a number of biological activities including T cell-independent induction of interferon (IFN)-gamma. Important for the differentiation of both Th1 and Th2 cells. |
Wada et al. 2007 |
| Il12b, interleukin 12b | IL12 p40 subunit. Cytokine expressed by activated macrophages and important for Th1 cell development, regulation and memory. |
Kugathasan et al. 2007 |
| Il1rn, interleukin 1 receptor antagonist | This protein inhibits the activity of interleukin 1 alpha (IL1A) and beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. |
Bioque et al. 1996 |
| Myd88, myeloid differentiation primary response gene 88 | Adapter protein involved in Toll-like receptor and interleukin 1 receptor signaling pathways within the innate immune response. Activates the transcription factor NF-kappa-B. |
Fukata et al. 2005. |
| Nos2, nitric oxide synthase 2, inducible | Encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. |
Porras et al. 2006 |
| Rela, v-rel reticuloendotheliosis viral oncogene homolog A | NF-kappa-B or p65 is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. |
Inoue et al. 2009 |
| Pomc, pro-opiomelanocortin-alpha | Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. |
Farhadi et al. 2005 |
| Pparg, peroxisome proliferator activated receptor gamma | Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases. |
Dubuquoy et al. 2003 |
| Ptgs2, prostaglandin-endoperoxide synthase 2 | Participates in synthesizing prostanoids involved in pain and inflammation. Also known as cyclooxygenase-2 (COX2). |
Singer et al. 1998 |
| Tlr2, toll-like receptor 2 | Surface receptor present on multiple immune cells. Binds diverse pathogenic substances and initiates innate immune responses. Also known as CD282 and Ly105. | Tanaka 2008 |
| Tlr4, toll-like receptor 4 | Surface receptor for lipopolysaccharides from Gram-negative bacteria. Receptor engagement initiates innate immune response. |
De Jager et al. 2007 |
| Tnf, tumor necrosis factor | Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types. |
Ferguson et al. 2008 |
| Vdr, vitamin D receptor | Nuclear receptor capable of transactivating vitamin-D responsive genes. |
Froicu and Cantorna 2007 |
| At this time there are no JAX® Mice strains available for the following symbol(s): Il23a. | ||