Featured JAX® Mice for autoimmunity

Inducible models for autoimmune diseases

In addition to the mutant JAX® Mice strains listed throughout this resource, the table below offers an overview of more than a dozen popular autoimmune disease-susceptible strains. These inducible mouse models recapitulate many aspects of the human disease and generally have a short latency to disease onset. 


Stock No. Strain Name Disease development Reference
000664 C57BL/6J  inducible (DSS) Mahler et al. 1998
000651 BALB/cJ inducible (TNBS) Blumberg et al. 1999
001976 NOD/ShiLtJ inducible (DSS) Mahler et al. 1998
Rheumatoid arthritis
Stock No. Strain Name Disease development Reference
000670 DBA/1J inducible (collagen) Malfait et al. 2001
000651 BALB/cJ inducible (collagen-antibody) Lange et al. 2005
000653 BUB/BnJ inducible (collagen) Haqqi et al. 1995
Stock No. Strain Name Disease development Reference
000651 BALB/cJ  inducible (OVA) Beigelman et al. 2009
Multiple Sclerosis
Stock No. Strain Name Disease development Reference
000686 SJL/J inducible (proteolipid protein) Duzhak et al. 2003
001026 BALB/cByJ  inducible Teuscher et al. 1987
100008 NZBWF1/J inducible (MBP) Zamvil et al. 1994
000457 B10.RIII-H2r H2-T18b/(71NS)SnJ inducible (MBP) Zhao et al. 1993
Stock No. Strain Name Disease development Reference
001803 CBySmn.CB17-Prkdcscid/J inducible (adoptive T cell transfer) Davenport et al. 2002

Helper T Cell Profile in Mouse Models of Autoimmune Disease

Helper T cells are lymphocytes capable of activating and directing a variety of immune cells to generate a successful immune response to infection. Three major subgroups of Th cells have been defined, Th1, Th2, and Th17, each with distinct cytokine products and biological functions*. Understanding the Th cell subgroup involved in autoimmune disease pathogenesis may lead to the development of novel treatments or identification of better models for efficacy testing current therapies for common autoimmune diseases. This resource lists the Th cell subset(s) linked to each specific mouse model, the particular cytokines secreted by each Th cell subgroup, and supporting references.

  Helper Cell Subset*
Disease Area Model Mouse Strain Th1 Th2 Th17
Inflammatory Bowel Disease DSS-induced (acute) C57BL/6J (000664) or BALB/cJ (000651) - - -
DSS-induced (chronic) C57BL/6J (000664)


Alex et al. 2009


  TNBS-induced BALB/cJ (000651) +
Neurath et al. 1995
- +
Daniel et al. 2008
Adoptive CD4+CD45RBhi
T cell transfer
CBySmn.CB17-Prkdcscid/J (001803) +
Ogino et al. 2011
Kanai et al. 2006
Kulberg et al. 2006
Rheumatoid Arthritis Collagen antibody-induced BALB/cJ (000651) - - -
  Collagen-induced DBA/1J (000670) DBA/1LacJ (001140) +
Malfait et al. 1998
- +
Lubberts et al. 2004
Asthma OVA-induced BALB/cJ (000651) - +
Webb et al. 2000
Hellings et al. 2003
Multiple Sclerosis PLP-EAE
SJL/J (000686)
C57BL/6J (000664)
Mohindru et al. 2004
- +
O'Connor et al. 2008
Psoriasis CD4+CD45RBhi Adoptive T cell transfer CBySmn.CB17-Prkdcscid/J (001803) +
Hong et al. 2011
- +
Ma et al. 2008

* Th1: Initiating Cytokine IL-12; Effector Cytokines INFγ, IL-2, TNFβ
   Th2: Initiating Cytokine IL-4 Effector Cytokines IL-5, IL-4, IL-13, IL-6
   Th17: Initiating Cytokine IL-21, TNFβ, IL-6 Effector Cytokines IL-17, IL-22, IL-26