Featured JAX® Mice for autoimmunity
Inducible models for autoimmune diseases
In addition to the mutant JAX® Mice strains listed throughout this resource, the table below offers an overview of more than a dozen popular autoimmune disease-susceptible strains. These inducible mouse models recapitulate many aspects of the human disease and generally have a short latency to disease onset.
IBD
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000664 | C57BL/6J | inducible (DSS) | Mahler et al. 1998 |
| 000651 | BALB/cJ | inducible (TNBS) | Blumberg et al. 1999 |
| 001976 | NOD/ShiLtJ | inducible (DSS) | Mahler et al. 1998 |
Rheumatoid arthritis
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000670 | DBA/1J | inducible (collagen) | Malfait et al. 2001 |
| 000651 | BALB/cJ | inducible (collagen-antibody) | Lange et al. 2005 |
| 000653 | BUB/BnJ | inducible (collagen) | Haqqi et al. 1995 |
Asthma
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000651 | BALB/cJ | inducible (OVA) | Beigelman et al. 2009 |
Multiple Sclerosis
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 000686 | SJL/J | inducible (proteolipid protein) | Duzhak et al. 2003 |
| 001026 | BALB/cByJ | inducible | Teuscher et al. 1987 |
| 100008 | NZBWF1/J | inducible (MBP) | Zamvil et al. 1994 |
| 000457 | B10.RIII-H2r H2-T18b/(71NS)SnJ | inducible (MBP) | Zhao et al. 1993 |
Psoriasis
| Stock No. | Strain Name | Disease development | Reference |
|---|---|---|---|
| 001803 | CBySmn.CB17-Prkdcscid/J | inducible (adoptive T cell transfer) | Davenport et al. 2002 |
Helper T Cell Profile in Mouse Models of Autoimmune Disease
Helper T cells are lymphocytes capable of activating and directing a variety of immune cells to generate a successful immune response to infection. Three major subgroups of Th cells have been defined, Th1, Th2, and Th17, each with distinct cytokine products and biological functions*. Understanding the Th cell subgroup involved in autoimmune disease pathogenesis may lead to the development of novel treatments or identification of better models for efficacy testing current therapies for common autoimmune diseases. This resource lists the Th cell subset(s) linked to each specific mouse model, the particular cytokines secreted by each Th cell subgroup, and supporting references.
| Helper Cell Subset* | |||||
|---|---|---|---|---|---|
| Disease Area | Model | Mouse Strain | Th1 | Th2 | Th17 |
| Inflammatory Bowel Disease | DSS-induced (acute) | C57BL/6J (000664) or BALB/cJ (000651) | - | - | - |
| DSS-induced (chronic) | C57BL/6J (000664) |
- |
- |
||
| TNBS-induced | BALB/cJ (000651) | + Neurath et al. 1995 |
- | + Daniel et al. 2008 |
|
| Adoptive CD4+CD45RBhi T cell transfer |
CBySmn.CB17-Prkdcscid/J (001803) | + Ogino et al. 2011 |
+ Kanai et al. 2006 |
+ Kulberg et al. 2006 |
|
| Rheumatoid Arthritis | Collagen antibody-induced | BALB/cJ (000651) | - | - | - |
| Collagen-induced | DBA/1J (000670) DBA/1LacJ (001140) | + Malfait et al. 1998 |
- | + Lubberts et al. 2004 |
|
| Asthma | OVA-induced | BALB/cJ (000651) | - | + Webb et al. 2000 |
+ Hellings et al. 2003 |
| Multiple Sclerosis | PLP-EAE MOG-EAE |
SJL/J (000686) C57BL/6J (000664) |
+ Mohindru et al. 2004 |
- | + O'Connor et al. 2008 |
| Psoriasis | CD4+CD45RBhi Adoptive T cell transfer | CBySmn.CB17-Prkdcscid/J (001803) | + Hong et al. 2011 |
- | + Ma et al. 2008 |
* Th1: Initiating Cytokine IL-12; Effector Cytokines INFγ, IL-2, TNFβ
Th2: Initiating Cytokine IL-4 Effector Cytokines IL-5, IL-4, IL-13, IL-6
Th17: Initiating Cytokine IL-21, TNFβ, IL-6 Effector Cytokines IL-17, IL-22, IL-26