Asthma Mouse Model Resource

Inducible Models

Stock No. Strain Name Disease development Reference
000651 BALB/cJ  inducible (OVA) Beigelman et al. 2009

JAX® Mice for asthma research

Gene Gene/protein function and details Reference
Ccl2, chemokine (C-C motif) ligand 2 Small cytokine belonging to the CC chemokine family; also known as monocyte chemotactic protein-1 (MCP-1). Recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection.

Chelbi et al. 2008

Cd80, Cd80 antigen Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG.

van Rijt et al. 2004

Cd86, Cd86 antigen Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2.

van Rijt et al. 2004

Ifng, interferon gamma Cytokine critical for innate and adaptive immunity. Aberrant expression is associated with a number of autoinflammatory and autoimmune diseases.

Cohn et al. 2001

Il2ra, interleukin 2 receptor, alpha chain The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25.

Xia et al. 2006

Il4, interleukin 4 Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity.

Brusselle et al. 1994

Il10, interleukin 10 An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation.

Koya et al. 2007

Il12b, interleukin 12b IL12 p40 subunit. Cytokine expressed by activated macrophages and important for Th1 cell development, regulation and memory.

Meyts et al. 2006

Myd88, myeloid differentiation primary response gene 88 Adapter protein involved in Toll-like receptor and interleukin 1 receptor signaling pathways within the innate immune response. Activates the transcription factor NF-kappa-B.

Yang et al. 20091

Nos2, nitric oxide synthase 2, inducible Encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines.

Trifilieff et al. 2000

Pomc, pro-opiomelanocortin-alpha Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.

Raap et al. 2003

Pparg, peroxisome proliferator activated receptor gamma Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases.

Honda et al. 2004

Tlr2, toll-like receptor 2 Surface receptor present on multiple immune cells. Binds diverse pathogenic substances and initiates innate immune responses. Also known as CD282 and Ly105.

Buckland et al. 2008

Tlr4, toll-like receptor 4 Surface receptor for lipopolysaccharides from Gram-negative bacteria. Receptor engagement initiates innate immune response.

Yang et al. 2009

Tnf, tumor necrosis factor Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types.

Hutchison et al. 2008

Vdr, vitamin D receptor Nuclear receptor capable of transactivating vitamin-D responsive genes.

Wittke et al. 2007