Rheumatoid Arthritis Mouse Model Resource

Inducible Models

Stock No. Strain Name Disease development Reference
000457 B10.RIII-H2r H2-T18b/(71NS)SnJ inducible (collagen) Myers et al 1995
000670 DBA/1J inducible (collagen) Malfait et al. 2001
000651 BALB/cJ inducible (collagen-antibody) Lange et al. 2005
000653 BUB/BnJ inducible (collagen) Haqqi et al. 1995

JAX® Mice for rheumatoid arthritis research

Gene Gene/protein function and details Reference
Ccl2, chemokine (C-C motif) ligand 2 Small cytokine belonging to the CC chemokine family; also known as monocyte chemotactic protein-1 (MCP-1). Recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection.

Okamoto et al. 2008

Cd4, Cd4 antigen Glycoprotein expressed on the surface of helper T lymphocytes and other immune cells. CD4 functions to initiate or augment the early phase of T cell activation.

Hirota et al. 2007

Cd40, CD40 antigen A costimulatory protein found on antigen presenting cells and is required for their activation

van der Linden et al. 2009

Cd40lg, CD40 ligand Protein expressed on both CD4+ and CD8+ T cells that aids in stimulating B cells in the immune response.

Lee et al. 2006

Cd80, Cd80 antigen Cd80 encodes B7-1, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly53 and CD28LG.

Buch et al. 2008

Cd86, Cd86 antigen Cd86 encodes B7-2, which provides a costimulatory signal necessary for T cell activation and survival. Expressed on a variety of hematopoietic cell types. Also known as Ly58 and CD28LG2.

Lagana et al. 2009

Ciita, class II transactivator Positive regulator of Class II major histocompatibility complex (MHC) gene transcription, functioning through activation of the transcription factor RFX5. Considered the "master control factor", needed for expression of MHC Class II genes.

Swanberg et al. 2005

Ifng, interferon gamma Cytokine critical for innate and adaptive immunity. Aberrant expression is associated with a number of autoinflammatory and autoimmune diseases.

Sattler et al. 2009

Il2ra, interleukin 2 receptor, alpha chain The interleukin 2 receptor alpha (IL2RA), beta (IL2RB), and the common gamma chain (IL2RG) constitute the high-affinity IL2 receptor, expressed on immune cells, such as lymphocytes. Also known as Ly43 and CD25.

van Amelsfort et al. 2007

Il4, interleukin 4 Cytokine that induces differentiation of naive helper T cells. A key regulator of adaptive immunity.

Finnegan et al. 2002

Il6, interleukin 6 An interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine.

Brennan and McInnes. 2008

Il7, interleukin 7 Cytokine important for B and T cell development. Plays an essential role in lymphoid cell survival.

Churchman and Ponchel. 2008

Il10, interleukin 10 An anti-inflammatory cytokine primarily produced by monocytes, which has pleiotrophic effects in immunoregulation and inflammation.

Antoniv and Ivashkiv. 2006

Il12a, interleukin 12a Cytokine which has a number of biological activities including T cell-independent induction of interferon (IFN)-gamma. Important for the differentiation of both Th1 and Th2 cells.

Wada et al. 2007

Il12b, interleukin 12b IL12 p40 subunit. Cytokine expressed by activated macrophages and important for Th1 cell development, regulation and memory.

Wada et al. 2007

Il1rn, interleukin 1 receptor antagonist This protein inhibits the activity of interleukin 1 alpha (IL1A) and beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses.

Ljung et al. 2007

Myd88, myeloid differentiation primary response gene 88 Adapter protein involved in Toll-like receptor and interleukin 1 receptor signaling pathways within the innate immune response. Activates the transcription factor NF-kappa-B.

Sacre et al. 2007

Pomc, pro-opiomelanocortin-alpha Encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage. Gives rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.

Slominski et al 1993

Pparg, peroxisome proliferator activated receptor gamma Member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors, which regulate transcription of various genes. Implicated in the pathology of numerous diseases.

Okamoto et al. 2005

Ptgs2, prostaglandin-endoperoxide synthase 2 Participates in synthesizing prostanoids involved in pain and inflammation. Also known as cyclooxygenase-2 (COX2).

Siegle et al. 1998

Tlr2, toll-like receptor 2 Surface receptor present on multiple immune cells. Binds diverse pathogenic substances and initiates innate immune responses. Also known as CD282 and Ly105.

Huang et al. 2009

Tlr4, toll-like receptor 4 Surface receptor for lipopolysaccharides from Gram-negative bacteria. Receptor engagement initiates innate immune response.

Abdollahi-Roodsaz et al. 2007

Tnf, tumor necrosis factor Pleiotropic cytokine promoting inflammation, cell death, proliferation and other responses. Synthesized by many cell types.

Brennan and McInnes. 2008

Vdr, vitamin D receptor Nuclear receptor capable of transactivating vitamin-D responsive genes.

Cutolo et al. 2007