CRISPR White Papers & Case Studies

  • Strategies to Maximize the Reproducibility of Mouse Research

    While it cannot be stopped completely, genetic drift and the impact on scientific discovery can be minimized through careful and thoughtful colony management practices. Download our new whitepaper to learn more.

  • Case Study: Generation of a SNP Allelic Series to Study FALS

    JAX MGS utilized a short oligo-mediated knockin approach to generate a small mouse model panel in which each model carries a mouse allele that has been modified to carry a different, specified amino acid at key orthologous positions identified in the FALS patient analysis.

  • Fact Sheet: Mouse Model Generation

    JAX can help you design the model you need and produce it on the genetic background of your choice by leveraging our 85+ years of mouse experience and our 8,500 mouse models. The guide explains how we can help every step of the way, from concept to providing phenotypic characterization, allowing you and your staff to focus on the research instead of breeding mice.

  • Guide: Generating Mouse Models with CRISPR/Cas9

    Genome editing with CRISPR/Cas9 enables the generation of new mouse models with unprecedented speed and simplicity. The Jackson Laboratory was an early adopter of CRISPR/Cas9 technology for mouse model development, and in this brief guide we describe the technology and lessons learned to generate knockouts and knockins in more than a dozen different genetic backgrounds.

  • Cre-dependent Fxn Knockout Allele for Friedreich’s Ataxia

    To support a collaboration between Dr. Cat Lutz of The Jackson Laboratory and the Friedrich’s Ataxia Research Alliance, our Model Generation Services (MGS) team undertook a project to create a conditional knockout allele of the Frataxin (Fxn) gene using the Cre-loxP Recombination System.