CRISPR/Cas9 Precision Mouse Models

Work with the world leader in generating precision mouse models. JAX can generate the models you need for your research project, including custom genetically humanized mice. 

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Project Process & Timeline

Work with the world leader in mouse model generation. We will:

  1. Discuss your goals and develop a detailed strategy of how we will generate your model.
  2. Provide you with regular updates on your project.
  3. Develop a founder data packet and discuss the results with you.
  4. Develop an N1 data packet (germ line competent and genetically validated) and discuss the results with you.
  5. Deliver your N1 mice to you, or provide you with options to quickly expand your colony and cryopreserve your new strain.


Model Type Timeline (Weeks)
Small and Large Knockins
Including ROSA 26 locus
27 - 37
Gene Knockout
Deletion KO, Indel-mediated KO
26 - 31
Conditional Knockout
i.e. flox
33 - 37
Genetic Humanization
SNP and plasmid based
27 - 37
Tool Development
Reporter and TAG insertions
27 - 37

CRISPR Licenses

All JAX models generated with the CRISPR/Cas9 technology are under limited use licenses from both The Broad Institute, Inc. and Caribou Biosciences, Inc. View full license terms here.

Additional Services

Save time and effort when you opt for additional services, such as the rapid generation of large aged-matched cohorts of study-ready mutant mice. Additional services include:

  • Off-target effects analysis
  • Breeding services for further model characterization
  • Rapid generation of large cohorts through our Speed Expansion Service and regular delivery via Dedicated Supply
  • Cryopreservation of new CRISPR models
  • Pilot studies to characterize the expression of human immune cell protein, tumor proteins, or antigens in your model system
  • PK studies, including therapeutic antibody half-life evaluation
  • Preclinical efficacy studies with your compound