Jackson Laboratory

ANXA11 R346C REV/WT

Product Code: JIPSC1258

Background

Genetics

Gene

ANXA11

Condition

Amyotrophic lateral sclerosis

Allele Charactertistics

Autosomal Dominant

View Information in ClinVar

Derived from Cell Line

JIPSC1220_ANXA11_R346C_SNV/WT

Genomic Features

Genomic Coordinate (GRCh38)

chr10:80163399 (-)

Genomic Sequence

CACCTGCTTCCTTTCAGGGAAAC[C/T]GTGATGAAAGCACAAACGTGG
View With Genome Browser

dbSNP

rs770574196

Gene Editing Reagents

Nuclease

SpCas9

Protospacer Sequence

TTCATCACAGTTTCCCTGAA

Donor Template

CCGCAATGAGGAAAGGGAAAATAAATGGGGAAGGAGTGGGCATGACCATACACCTGCTTCCTTTCAGGGAAACCGTGATGAAAGCACAAACGTGGACATG

DNA Primers for Sequence Validation

PCR Forward

ACCCATCTTCTGCCACCCCCAATAC

PCR Reverse

AATGTGGCAGCTGGTTTCTAGGCTC

Sanger Sequencing Primer

ATCCCTGCTTTAGGAAGTCC

Quality Control Data

Certification of Quality Analysis

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Sequencing

Lead Clone Sanger Sequencing

Sanger Sequence

Sequence Maps

Karyotype & Array Data