Oncology Solutions

Be confident in your go or no-go decisions with translationally-relevant data from JAX preclinical oncology solutions. By combining genetically defined tumors with cutting-edge mouse models and unique human immune cell engraftment, JAX enables the validation of diverse oncology drug discovery candidates in an array of in vivo platforms that better recapitulate the human condition.

micetech@jax.org | 1.800.422.6423 (US) | 1.207.288.5845 (International)

JAX provides the most innovative preclinical models and accurate proof-of-concept studies to delineate the mechanisms underlying the disease. With these essential tools, researchers can pursue the right therapeutic candidate.

define target

Better data starts by selecting the right platform for your study. Confidently define your target with JAX:

MOUSE GENE

JAX® Mice – Access over 11,000 diverse mouse models at the highest health standards.

Model Generation Services – From Concept to data- trust JAX expertise to design an optimal model for your study.
HUMAN TUMOR

Tumor Biology (MTB) Database – Obtain relevant data including genotypic and phenotypic data for specific tumor strain.

PDX Repository – Select a tumor - Extensive tumor configurations with over 400 different tumor types.
IMMUNE CELL TARGET

Humanized Mice Platforms – Choose the platform that supports enhanced natural killer cell production, myeloid cells production, engraftment of multiple human tissues, and strong effector and memory T cell production.
affect target

Characterize the expression of human immune cell proteins, tumor proteins, or antigens.

TUMOR INTERROGATION

Formalin-Fixed, Paraffin-embedded (FFPE) PDX Slides – Utilize biomarker assays to screen your tissue sample Tumor Samples.
establish efficacy

Establish your proof-of-concept with access to JAX study-ready cohorts and preclinical solutions.

PRECLINICAL SOLUTIONS

PDX Studies – Utilize the JAX PDX platform to obtain translationally-relevant data.

Humanized Mouse Studies – Unique and diverse portfolio to simulate trials, or evaluate multiple drugs alone or in combination. Our platform that supports enhanced natural killer cell production, myeloid cells production, engraftment of multiple human tissues, and strong effector and memory T cell production.

Therapeutic Antibody Evaluation – Evaluate the in vivo stability of therapeutic antibodies and other Fc-based biologics using our unique platform of humanized FcRn models.
STUDY READY COHORTS

Humanized Mice – Robust in vivo platform for analyzing the safety and effectiveness of potential new drugs to modulate the immune system.

PDX Mice – Our PDX Mic are genetically characterized and at earlier passage numbers than any other PDX collection available today. Our collection includes readily available, off-the-shelf PDX Live tumor model cohorts allowing rapid study turnaround and faster decision-making.

FcRn Mice – Only JAX has a portfolio of humanized mouse models that are deficient in murine FcRn and express human FcRn at different levels.