Down Syndrome Mouse Model Resource

Featured JAX® Mice Models of Down Syndrome

B6EiC3Sn a/A-Ts(17¹⁶)65Dn/J

001924

• Common name: sighted Ts65Dn
• Genetic background: C57BL/6JEiJ (000924) and C3H/HeSnJ (000661)
• Carries a radiation-induced translocation of the distal end of chromosome 16 to the centromeric end of chromosome 17
• The trisomy of genes on chromosome 16 are homologous to regions of human chromosome 21
• Trisomic Ts65Dn females are bred to B6EiC3Sn.BLiAF1/J (003647) males every generation
  
• Phenotype: abnormal granular cell morphology and decreased density, decreased Purkinji cell number, abnormal spine morphology and density in neurons and dendrites
• Decreased body size is observed, as well as abnormal spatial learning, impaired contextual and cued conditioning behavior
• Segregating for the retinal degeneration allele Pde6b^rd1; mice may be heterozygous for rd1

B6EiC3Sn.BLiA-Ts(17¹⁶)65Dn/DnJ 

005252

• Common name: Ts65Dn
• Genetic background: mixed, containing C57BL/6JEiJ (000924) and C3Sn.BLiA-Pde6b⁺/DnJ (003648)
• Carries a radiation-induced translocation of the distal end of chromosome 16 to the centromeric end of chromosome 17
• The trisomy of genes on chromosome 16 are homologous to regions of human chromosome 21
• Trisomic Ts65Dn females are bred to B6EiC3SnF1/J (001875) every generation
  
• Phenotype: abnormal granular cell morphology and decreased density, decreased Purkinji cell number, abnormal spine morphology and density in neurons and dendrites
• Decreased body size is observed, as well as abnormal spatial learning, impaired contextual and cued conditioning behavior
• Wild-type for the retinal degeneration allele Pde6b^rd1: all mice have normal sight