Down Syndrome Mouse Model Resource
Explore our collection of mouse models of Down Syndrome and other strains with chromosomal aneuploidy.
- Cytogenetic and Down Syndrome Models Resource
- See a complete list of JAX® Mice for Down Syndrome research
Featured JAX® Mice Models of Down Syndrome
B6EiC3Sn a/A-Ts(1716)65Dn/J
- Common name: sighted Ts65Dn
- Genetic background: C57BL/6JEiJ (000924) and C3H/HeSnJ (000661)
- Carries a radiation-induced translocation of the distal end of chromosome 16 to the centromeric end of chromosome 17
- The trisomy of genes on chromosome 16 are homologous to regions of human chromosome 21
- Trisomic Ts65Dn females are bred to B6EiC3Sn.BLiAF1/J (003647) males every generation
- Phenotype: abnormal granular cell morphology and decreased density, decreased Purkinji cell number, abnormal spine morphology and density in neurons and dendrites
- Decreased body size is observed, as well as abnormal spatial learning, impaired contextual and cued conditioning behavior
- Segregating for the retinal degeneration allele Pde6brd1; mice may be heterozygous for rd1
B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ
- Common name: Ts65Dn
- Genetic background: mixed, containing C57BL/6JEiJ (000924) and C3Sn.BLiA-Pde6b+/DnJ (003648)
- Carries a radiation-induced translocation of the distal end of chromosome 16 to the centromeric end of chromosome 17
- The trisomy of genes on chromosome 16 are homologous to regions of human chromosome 21
- Trisomic Ts65Dn females are bred to B6EiC3SnF1/J (001875) every generation
- Phenotype: abnormal granular cell morphology and decreased density, decreased Purkinji cell number, abnormal spine morphology and density in neurons and dendrites
- Decreased body size is observed, as well as abnormal spatial learning, impaired contextual and cued conditioning behavior
- Wild-type for the retinal degeneration allele Pde6brd1: all mice have normal sight