Down Syndrome Mouse Model Resource

Explore our collection of mouse models of Down Syndrome and other strains with chromosomal aneuploidy.

Featured JAX® Mice Models of Down Syndrome

B6EiC3Sn a/A-Ts(1716)65Dn/J

001924

  • Common name: sighted Ts65Dn
  • Genetic background: C57BL/6JEiJ (000924) and C3H/HeSnJ (000661)
  • Carries a radiation-induced translocation of the distal end of chromosome 16 to the centromeric end of chromosome 17
  • The trisomy of genes on chromosome 16 are homologous to regions of human chromosome 21
  • Trisomic Ts65Dn females are bred to B6EiC3Sn.BLiAF1/J (003647) males every generation
  • Phenotype: abnormal granular cell morphology and decreased density, decreased Purkinji cell number, abnormal spine morphology and density in neurons and dendrites
  • Decreased body size is observed, as well as abnormal spatial learning, impaired contextual and cued conditioning behavior
  • Segregating for the retinal degeneration allele Pde6brd1mice may be heterozygous for rd1

B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 

005252

  • Common name: Ts65Dn
  • Genetic background: mixed, containing C57BL/6JEiJ (000924) and C3Sn.BLiA-Pde6b+/DnJ (003648)
  • Carries a radiation-induced translocation of the distal end of chromosome 16 to the centromeric end of chromosome 17
  • The trisomy of genes on chromosome 16 are homologous to regions of human chromosome 21
  • Trisomic Ts65Dn females are bred to B6EiC3SnF1/J (001875) every generation
  • Phenotype: abnormal granular cell morphology and decreased density, decreased Purkinji cell number, abnormal spine morphology and density in neurons and dendrites
  • Decreased body size is observed, as well as abnormal spatial learning, impaired contextual and cued conditioning behavior
  • Wild-type for the retinal degeneration allele Pde6brd1all mice have normal sight