Our portfolio of humanized mice support the development of functional cellular components of the human immune system. Mouse models with human immune cell engraftment represent ground-breaking platforms to evaluate compounds to treat a variety of human diseases.
JAX humanized mice include several host strains, each designed to improve specific aspects of human immune function. All are based on the NOD scid gamma (NSG™) mouse, developed by JAX Professor Lenny Shultz, a strain shown to support highly efficient engraftment of human hematopoietic stem cells (hu-CD34+) and human peripheral blood mononuclear cells (hu-PBMC). These host strains support the development of various human cells following humanization. The humanized NSG™-SGM3 strain supports improved myeloid and regulatory T cell development and the newly available CD34+ HSC NSG™-IL15 strain develops mature human natural killer (NK) cells at human physiological levels.
An additional model, the NSG™-A2, is currently undergoing characterization studies and is available on a limited basis.
Please inquire for more information.
Humanized CD34+ mice (hu-CD34) are a robust in vivo platform for analyzing the safety and effectiveness of potential new drugs to modulate the immune system. Hu-CD34+ mice are advantageous in vivo models for long-term studies in the fields of human immune cell biology, immuno-oncology, and infectious disease.
Models engrafted with cord blood-derived hematopoietic stem cells (HSC) develop multi-lineage engraftment and display robust T-cell maturation and T-cell dependent inflammatory responses. Large cohorts of humanized CD34+ NSG™ and NSG™-SGM3 mice are available for immediate delivery or to enroll in JAX drug efficacy testing services.
The latest model, the humanized NSG™-IL15 is now also available in limited quantities.
Humanized PBMC (hu-PBMC) mice feature quick engraftment of adult peripheral blood mononuclear cells and enable short-term studies requiring mature human T cells. Hu-PBMC mice are used as in vivo models to study and evaluate compounds for T cell immune modulation, infectious diseases and graft rejection research.
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THERAPEUTIC AREAS
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- Infectious Diseases
- Immuno-oncology
- Immunology
and more…
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- Graft vs. Host Disease (Immunology)
- Immuno-oncology
- Infection Disease
and more…
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BENEFITS
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- Long-term lifespan
- A functional immune system
- No donor cell immune reactivity towards host
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- Enables short to mid-term studies requiring
human T cells
- Strong effector and memory T cell function
- T cell-driven GvHD
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CELL DEVELOPMENT
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- T cells (MHC-restricted
CD4 and CD8)
- Monocytes
- Macrophages
- Mast cells
- Myeloid (SGM3)
- NK cells (IL15)
- Dendritic cells
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- B cells
- T cells (human donor
HLA-restricted CD4 and CD8)
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STRAIN HOSTS
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NSG™
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
strain #005557
NSG™-SGM3
NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ
strain #013062
Enhanced Myeloid cell production
NSG™-IL-15
NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(IL15)1Sz/SzJ
strain #030890
Enhanced Natural Killer cell production
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NSG™
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
strain #005557
NSG-(Kb Db)null (IA)null
NOD.Cg-Prkdcscid H2-K1tm1Bpe H2-D1tm1Bpe Il2rgtm1Wjl/SzJ
strain #025216
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