Humanized NSG™ represents an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in combination, and produce predictive data.
Our portfolio of humanized mice support the development of functional cellular components of the human immune system. Mouse models with human immune cell engraftment represent ground-breaking platforms to evaluate compounds to treat a variety of human diseases.
JAX humanized mice include several host strains, each designed to improve specific aspects of human immune function. All are based on the NOD scid gamma (NSG™) mouse, developed by JAX Professor Lenny Shultz, a strain shown to support highly efficient engraftment of human hematopoietic stem cells (hu-CD34+) and human peripheral blood mononuclear cells (hu-PBMC). These host strains support the development of various human cells following humanization. The humanized NSG™-SGM3 strain supports improved myeloid and regulatory T cell development and the newly available CD34+ HSC NSG™-IL15 strain develops mature human natural killer (NK) cells at human physiological levels.
An additional model, the NSG™-A2, is currently undergoing characterization studies and is available on a limited basis.
Please inquire for more information.
Humanized CD34+ mice (hu-CD34) are a robust in vivo platform for analyzing the safety and effectiveness of potential new drugs to modulate the immune system. Hu-CD34+ mice are advantageous in vivo models for long-term studies in the fields of human immune cell biology, immuno-oncology, and infectious disease.
Models engrafted with cord blood-derived hematopoietic stem cells (HSC) develop multi-lineage engraftment and display robust T-cell maturation and T-cell dependent inflammatory responses. Large cohorts of humanized CD34+ NSG™ and NSG™-SGM3 mice are available for immediate delivery or to enroll in JAX drug efficacy testing services.
The latest model, the humanized NSG™-IL15 is now also available in limited quantities.
Humanized PBMC (hu-PBMC) mice feature quick engraftment of adult peripheral blood mononuclear cells and enable short-term studies requiring mature human T cells. Hu-PBMC mice are used as in vivo models to study and evaluate compounds for T cell immune modulation, infectious diseases and graft rejection research.
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NSG™ NSG™-SGM3 NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(IL15)1Sz/SzJ |
NSG™ NSG-(Kb Db)null (IA)null |
Onco-Hu® Models are a robust platform for efficacy testing of novel immunotherapies targeting various immune cells, including T cells, myeloid cells, and NK cells.
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