In Vivo Studies and Solutions

Choose the Most Relevant In Vivo Studies for Your Research

Your study plan should be designed to give you the most accurate and clinically relevant data. JAX’s suite of in vivo studies, coupled with our customized study designs, will give you the opportunity to get the right data at the right time. Whether you are profiling a disease or evaluating a therapeutic, JAX has the resources you need to get the answers you need and the confidence to move forward.

In Vivo Studies & Capabilities

  • General Behavior & Fine Motor

  • Muscle Electrophysiology & Motor Movement

  • Cognition & Other Behavioral Phenotyping

  • Physiology & Cardiology

  • Metabolism

General Behavior & Fine Motor

  • Clinical Observation and Neuroscoring
  • Frailty Screen
  • Open Field Exploratory
  • Seizure Susceptibility
  • Whole Body Plethysmography

Muscle Electrophysiology & Motor Movement

  • Motor Unit Number Estimation (CMAP & RNS)
  • Nerve Conduction Velocity (NCV)
  • Muscle Force Recording
  • Dynamic Weight Bearing
  • Erasmus Ladder
  • Gait Analysis with Treadmill
  • Grip Strength
  • Homecage Wheel Running
  • Rotarod
  • Wire Hang

Cognition & Other Behavioral Phenotyping

  • Fear Conditioning
  • Novel Object Recognition
  • Elevated Zero Maze
  • Water Maze
  • Y-Maze
  • Light/Dark Box
  • Tail Suspension Test
  • Three Chamber Social Approach
  • Pre-Pulse Inhibition/Startle Reflex
  • Sensory and Nociception

Physiology & Cardiology

  • Auditory Brainstem Response
  • Electrocardiogram
  • Non-Invasive Blood Pressure
  • Piezoelectric Sleep
  • Ultrasonography with Echocardiogram


  • NMR Composition
  • Indirect Calorimetry
  • Glucose Tolerance Test
  • Insulin tolerance Test
  • Pyruvate Tolerance Test

Histopathology & Necropsy

After your study is complete, JAX can provide relevant tissue to further analyze internal phenotypes.

  • A sampling of Histopathology & Necropsy tests:

A sampling of Histopathology & Necropsy tests:

  • Glomerulonephritis
  • Skin (Infiltration of inflammatory cells)
  • Insulitis
  • Pancreatic β Cell Apoptosis (TUNEL-IHC)
  • Diabetic Retinopathy
  • Immunophenotyping
  • Seizure Susceptibility
  • Lymphadenopathy
  • Splenomegaly
  • Molecular Biology

  • Histology

Molecular Biology

  • Clinical Chemistry with over 40 biochemical assays, cytokine analysis and hematology profling
  • Quantification of protein, peptides, antibodies and hormones through ELISA
  • Real-time quantitative, reverse transcriptase and droplet digital PCR
  • Quantitative Western Blot with Simple Wes
  • Flow Cytometry
  • Meso Scale Discovery
  • Biodistribution for gene and cell therapies
  • Biomarker Assessment
  • Pharmacokinetics/Pharmacodynamics


  • Tissue Collection and Sectioning
  • Over 25 standard and special stains available
  • Over 100 validated antibodies for immunohistochemistry
  • Sample Imaging with Quantification

PK/PD, Toxicology and SAFETY

JAX has multiple studies specifically designed for drug testing research.

  • Our technologies include:

Our technologies include:

  • Pharmacokinectics
  • Cytokine Release Evaluation Studies

In Vivo Solutions by Therapeutic Area

Foundational In Vivo Platforms

Immunodeficient Models

ImmunodeficientNSG™ mouse model variants are the most immunodeficient mice available and the models of choice for cancer xenograft modeling, stem cell biology, humanized mice, and infectious disease research. Without a functional immune system, these models are viable hosts for other cells for research.

Find out more about our Immunodeficient NSG™ Platform

Humanized Models

Humanized NSG™ (human immune cell engrafted) models represent an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in combination, and produce predictive data. They can be used to evaluate potential lead candidates early in drug discovery, predict dosing range for a therapeutic, or in many other applications.

Find out more about our Humanized NSG™ Mice

Model Generation - Genetic Engineering

If one of the 12,000+ available strains isn’t ideal, JAX can genetically engineer a model specifically to meet your needs. We will work together to utilize the right strategy to get you the right data. Our experts have the experience needed to genetically engineer the model for your innovative research.

Find out more about our Model Generation Services