Zygote Editing of the NOD Mouse - Mechanism of Diabetes

 

Type 1 diabetes is a disease characterized by autoimmune destruction of the insulin producing pancreatic beta cells by autoreactive, pathogenic T cells. B lymphocytes play a key role in this process by acting as antigen presenting cells for these T cells. Dr. David Serreze of The Jackson Laboratory was interested in testing the hypothesis that the Aicda gene, which is required for class switch recombination/somatic hypermutation in B lymphocytes, is important in the development of diabetes. 

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