Guide: Mouse Models of Spinal Muscular Atrophy

This guide summarizes the history of SMA mouse model development. It describes the original models developed in the laboratories of Drs. Michael Sendtner at the University of Worzburg and Arthur Burghes at Ohio State University, the latest models that allow temporal and tissue specific control of SMN expression, and models under development.

It includes protocols for maintaining SMA models, criteria for choosing the right model(s), and techniques for maintaining the genetic and phenotypic integrity of future models.

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