Fact Sheet: Cancer Treatment Profile™

Molecular profiling of tumors is performed to identify mutations that accumulate in cancer cells, in particular driver mutations that can serve as treatment targets. Mutations identified in tumors usually include single nucleotide variants (SNVs), deletions and duplications. Fusion genes were originally associated with hematologic cancers; however, more than 300 gene fusions have been identified in almost every kind of solid tumor (sarcomas, carcinomas and tumors of the central nervous system). Identifying and characterizing the mutations in tumors therefore can have both diagnostic and therapeutic applications. The advent of next generation sequencing has enabled high-throughput, accurate molecular profiling across many tumor types.

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