Portfolio: Patient Derived Acute Myeloid Leukemia (AML) Models and Studies

Acute myeloid leukemia is a complex hematological malignancy with high molecular heterogeneity. JAX offers ten AML patient-derived xenograft (PDX) models with varying mutational profiles and treatment histories. These models are available for analyzing the effectiveness of potential new drugs–alone or in combination–to treat AML. These PDX models (Townsend et al.) have been engrafted in the highly immunodeficient NSG™-SGM3 (stock #013062), the mouse strain that most effectively engrafts human  myeloid leukemia.