Join JAX at ISTT 2017

Visit our booth to learn about our model generation services,
transgenic mouse models, breeding services,
genotyping services, and more.

Oct 1 - 4 | Salt Lake City, UT

  • Guide: Generating Mouse Models with CRISPR/Cas9

    Genome editing with CRISPR/Cas9 enables the generation of new mouse models with unprecedented speed and simplicity. The Jackson Laboratory was an early adopter of CRISPR/Cas9 technology for mouse model development, and in this brief guide we describe the technology and lessons learned to generate knockouts and knockins in more than a dozen different genetic backgrounds.

  • Case Study: Generation of a SNP Allelic Series to Study FALS

    JAX MGS utilized a short oligo-mediated knockin approach to generate a small mouse model panel in which each model carries a mouse allele that has been modified to carry a different, specified amino acid at key orthologous positions identified in the FALS patient analysis.