First Look Strains

These Foxp3^ΔEGFPiCre knock-in/knock-out mice have an IRES-EGFP/icre recombinase fusion gene inserted in the X-linked forkhead box P3 (Foxp3) gene. Male hemizgyotes are runted and die of autoimmune lymphoproliferation. This strain may useful tool for studying Treg function and development.

Tim-3^fl mutant mice possess loxP sites flanking exon 4 of the Havcr2 (hepatitis A virus cellular receptor 2, also known as Tim-3) gene and may be useful in generating conditional mutations to study Tim-3⁺ Treg cells and cancer.

Usp14^nmf375 mice carry an ENU-induced mutation that results in a 95% reduction of USP14 protein. On the C57BL/6 background, mice homozygous for the mutation die at or before birth. These mice may be useful for the study of adult-onset motor endplate disease.

Thy1-Usp14CA transgenic mice express a pan-neuronal specific mouse Usp14 (ubiquitin specific peptidase 14) gene modified to incorporate the C114A mutation, which alters the active site cysteine to alanine. Thy1-Usp14CA mice exhibit including impaired muscle development, motor endplate degeneration and impaired synaptic transmission at the neuromuscular junction.

R26-GFP_KI-TLR2 ("traffic light reporter") knock-in mice have a CAG promoter controlling expression of Venus (GFP) and TagRFP inserted in the Gt(ROSA)26Sor locus and is a reporter for DNA repair pathways.

Of note: the TLR2 allele also is distributed on a mixed C57BL/6 and 129S6 background - Stock No. 032672.

NSG-SGM3-IL15 mice expressing human IL3, GM-CSF (CSF2), SCF (KITLG), and IL15 combine the features of the highly immunodeficient NOD scid gamma (NSG) mouse with cytokines that support the stable engraftment of myeloid lineages, regulatory T cell populations and NK cells. As a result, these NSG-SGM3-IL15 mice allow superior engraftment of diverse hematopoietic lineages than other models and are useful for immuno-oncology, immunology and infectious disease studies.

To order this model with CD34+ or PBMC engraftment, please visit our Humanized Mice page.

GPI-DAF KO mice have the exons 1-3 of the Cd55 (CD55 molecule, decay accelerating factor for complement, also known as GPI-DAF) gene replaced by a neomycin cassette. Homozygous null mice have an increased susceptibility to experimental myasthenia gravis (EAMG) and complement-mediated renal injury. This strain maybe useful for studies of the regulation of complement activation.

Cd59-/- (KO) mice have the exon 2 of the Cd59a (Cd59a antigen) gene replaced by a neomycin cassette. This strain maybe useful for studies of the regulation of complement activation and the membrane attack complex (MAC).

Bard1-K132N knock-in mice express the codon 132 amino acid substitution lysine to asparagine in the Bard1 (BRCA1 associated RING domain 1) locus. This strain may be useful in studies of tumor suppression and breast cancer.

Irp2^flx mutant mice possess loxP sites flanking exon 3 of the Ireb2 (iron responsive element binding protein 2 or Irp2) gene and may be useful in generating conditional mutations to study iron distribution and hematopoiesis.

B6.RMCE[K18-HuACE2] mice express human ACE2, the receptor used by severe acute respiratory syndrome coronavirus (SARS-CoV) to gain cellular entry. The human keratin 18 promoter directs expression to epithelial cells, including airway epithelia where infections typically begin. Because K18-HuACE2 mice are susceptible to SARS-CoV-2 and SARS-CoV viruses, they may be useful for studying antiviral therapies to COVID-19 and SARS.

JAX is dedicated to supporting the scientific community in its response to the COVID-19 pandemic. View our portfolio of available models for SARS-CoV-2 research.

Ptpn22 knockout mice have a 13 nucleotide insertion (indel mutation) in exon 14 of the Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) gene. On the autoimmune type 1 diabetes (T1D) susceptible NOD/LtShiJ background, the mutation enhances onset and penetrance of T1D.

Xpr1^lox conditional mutant mice possess loxP sites flanking exon 2 of the Xpr1 (xenotropic and polytropic retrovirus receptor 1) gene and may be useful in generating conditional mutations to study inorganic phosphate (Pi) regulation and bone and kidney disorders.

This humanized NSG Flt3KO hFLT3LG Tg strain when engrafted with human HSC is expected to show improved development of DC, pDC, monocytes, NK cells and mucosal immune system.

LratCre transgenic mice express a cre recombinase directed by mouse Lrat (lecithin-retinol acyltransferase [phosphatidylcholine-retinol-O-acyltransferase]) promoter elements. Cre recombinase activity is observed in hepatic stellate cells in the liver as well as in Lrat-expressing cells of other organs. This strain may be useful for in vivo lineage tracing and functional analysis of hepatic stellate cells in liver fibrosis.

Please note: LratCre females, but not males, must be used for breeding; breeding through the male may permanently alter cre activity. LratCre males may be used for experiments.

The wild-derived M.m. domesticus pre-incipient inbred line ManA/NachJ may be used in crosses with common inbred strains to create multi-parent mouse mapping populations and for use as a source of natural phenotypic variation.