The newest additions to our ever-growing collection of cutting-edge mouse models.
Can't find what you're looking for? Go to Mouse Search
Stock Number | Name | Common Name | Description |
---|---|---|---|
038448 | C57BL/6N-Tg(CAG-UFObow1.0)1Jnchn/J | UFObow | These UFObow mice have a CAG promoter followed by three pairs of heterospecific lox sites (loxN, lox2272 and loxP) separating four fluorescent proteins. It functions as a Cre recombinase-inducible reporter of either a secreted luciferase (secNluc) or one of three blue-excitable fluorescent proteins. |
038164 | B6.Cg-Gt(ROSA)26Sortm1Hjf/J | ROSA-tdRFP | ROSA26-tdRFP knock-in mice allow cre-inducible expression of a robust tandem dimer RFP (tdRFP) fluorescent reporter from the ubiquitously expressed Gt(ROSA)26Sor locus. This strain may be useful as a tool that is compatible with GFP- or YFP-expressing mice for in vivo lineage tracing and fate-mapping studies. |
035831 | C57BL/6-Crbntm2.1Ble/J | Crbn |
CrbnV380E/I391V mice carry both V380E and I391V changes in the mouse Crbn (cereblon) gene, providing an in vivo model for studying the effects of a newer thalidomide analogues and are suitable for use in applications related to the study of haematological malignancy, thalidomide analogue treatment, and treatment-induced cytopenias and teratogenicity. |
038436 | C57BL/6J-Crybb1em1(icre)Cln/J | Crybb1-iCre | Crybb1-iCre knock-in/knock-out mice have an iCre recombinase gene inserted into exon 1 of the crystallin, beta B1 (Crybb1) locus, abolishing endogenous Crybb1 expression. When these mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequences in the Crybb1-expressing cells of the offspring. These mice may be useful for tracking microglia and border-associated macrophages (BAMS) during embryonic development. |
036600 | STOCK Ts(1716)66Yah/J | Ts66Yah | Ts66Yah mice are trisomic for about two-thirds of the genes orthologous to human chromosome 21, but lack the non-homologous 6.2Mb 1716 minichromosomal segment. These mice may be used for studying Down Syndrome. |
035456 | C57BL/6J-Abcb1aem1Sbkv/SndrdJ | Abcb1a |
CRISPR/Cas9 generated Abcb1aametrine mice express the ametrine fluorescent reporter sequence directed from the endogenous ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a) promoter. They are useful for visualizing MDR1 expressing cells, and for studying T cell-mediated immunity and inflammation, as well as regulation of oxidative stress. |
038163 | B6.129P2(Cg)-Kmt2etm1.1Hjf/J | Mll5-flox | Mll5-flox mice possess loxP sites flanking exons 3-4 (encoding the PHD domain) of the lysine (K)-specific methyltransferase 2E (Kmt2e, also known as Mll5) gene. These floxed mice are useful for tissue specific deletion of Kmt2e when studying Mll5 (Kmt2e) regulation of hematopoietic stem/progenitor cells. |
038301 | B6;SJL-Tg(ACTA1-rtTA)6Mcrth/J | HSA-rtTA | HSA-rtTA mice are a Tet-On tool that allows doxycycline-inducible expression of the reverse tetracycline-controlled transactivator (rtTA) protein in skeletal muscle using the human skeletal muscle α-actin (ACTA1) promoter. |
038162 | B6.Cg-Gata3tm1.1Hjf/J | GATIR | GATIR knock-in mice carry a Venus yellow fluorescent reporter inserted into the Gata3 (GATA binding protein 3) locus. The insertion does not affect GATA3 expression and mice homozygous for the mutation are viable and fertile. This strain may be useful as a reporter for Gata3 expression in the T cell lineage, subsets of innate lymphoid cells (ILCs), a subset of thymus-derived NK cells, and in long-term hematopoietic stem cells. |
038594 | B6.129-H3f3atm1Hjf/J | H3.3A-K27M-FLAG | H3.3A-K28M conditional knock-in mice carry a K27M (see note) amino acid substitution, a 3XFLAG tag, and Venus reporter preceded by loxP-flanked wildtype H3f3a cDNA and an frt-flanked neo cassette in the H3f3a (H3.3 histone A) gene. This strain may be useful for research in cancers associated with the H3.3 variant. |
037717 | B6;D2-Tg(tetO-GCaMP8s)1Genie/J | TetO‐jGCaMP8s | TetO-jGCaMP8s transgenic mice express jGCaMP8s (an improved fast rise, moderate decay green fluorescent-based GECI with improved sensitivity and faster kinetics) controlled by a tetracycline‐responsive promoter element (TRE; tetO). When crossed with a transgenic mouse expressing tetracycline‐controlled transactivator protein (tTA), the jGCaMP8s transgene is activated and expression can be regulated with doxycycline. |
037818 | B6.Cg-Col1a1tm1(tetO-cas9*)Ldow/Mmjax | Inducible Base Editor (IBE) | iBE knockin mice express a cytosine base editor (C:G to T:A) under the control of a tetO promoter. This strain provides temporal and regulatable in vivo cytosine base editing to create cancer-associated single nucleotide variants (SNVs). |
037275 | NOD.Cg-Rag2em8Lutzy H2-K1b-tm1Bpe H2-Ab1g7-em1Mvw H2-D1b-tm1Bpe Il2rgtm1Wjl/J | NRG-DKO , NRG-MHC I/II DKO | NRG-MHC I/II DKO mutant mice combine the features of the recombination activating 2 gene (Rag2) null mutation, IL2 receptor gamma chain deficiency (Il2rg), MHC class I molecule deficiency (H2-K and D), and MHC class II molecule deficiency (IA) and exhibit a resistance to graft versus host disease (GVHD). They provide a model useful to study in vivo mechanisms of xenogeneic GVHD and to rapidly assess therapeutic agents. |
037276 | NOD.Cg-Rag2em8Lutzy Il2rgtm1Wjl/J | Rag2 |
These Rag2delEx3 IL2Rγnull mice contain a knock-out of the Rag2 gene from Stock No. 033537 and a knockout of the X-linked Il2rg gene from Stock No. 003174. These mice may be useful in studying B and T cell deficiency as well as for xenograft/transplantation. |
037892 | C57BL/6J-Tg(Thy1-APPDutch)#Jckr/J | APPDutch | APPDutch mice contain the Dutch E693Q mutation under direction of the Thy1 promoter and may be useful for studying the vascular amyloid aspect of Alzheimer's disease. |
038643 | C57BL/6J-Del(12Ighg3-Ighg2b)1Mzeng/J | IgG KO | IgG knock-out mice have an 80 kbp deletion that removes the IgG isotypes (Ighg1, Ighg2a, Ighg2b, and Ighg3). Homozygous mice develop an altered gut microbiome that promotes differentiation of IL17A-producing δγ T cells. This strain may be useful for research involving enteric pathogens and the gut microbiome. |
038496 | C57BL/6J-Gata3em1Aben/J | Gata3 |
Gata3Citrine knock-in mice carry a citrine fluorescent reporter inserted into the Gata3 (GATA binding protein 3) locus, while retaining endogenous Gata3 expression. This strain may be useful as a reporter for Gata3 expression in the T cell lineage and subsets of innate lymphoid cells (ILCs). |
038498 | C57BL/6J-Tcf7em1Aben/J | Tcf7 |
Tcf7mCherry knock-in mice carry an mCherry/3xFLAG reporter inserted into the Tcf7 (transcription factor 7, T cell specific) locus, while retaining endogenous Tcf7 expression. This strain may be useful as a reporter for Tcf7 expression in the T cell lineage and lymphoid tissue inducer (LTi) populations. |
037459 | STOCK Tg(Lmx1a-EGFP/cre)3Kjmi/J | Lmx1a-Cre | Lmx1a-Cre transgenic mice express a Cre recombinase/EGFP fusion under the control of the mouse Lmx1a (LIM homeobox transcription factor 1 alpha) promoter elements. Please note: the transgene inserted on the X chromosome. Cre recombinase activity is observed specifically in the roof plate (RF) and a subset of rhombic lip (RL) progenitors. This strain may be useful in fate mapping and manipulating gene expression in multiple Lmx1a populations. |
037676 | C57BL/6-Slc17a7tm1.1Thna/J | Slc17a7 |
Slc17a7flox mice possess loxP sites flanking exons 4-7 of the solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 (Slc17a7) gene. These mice may be useful for studying the role of Slc17a7 in learning and memory disorders, Alzheimer's disease, Parkinson's disease and other central nervous system diseases. |
038190 | B6.Cg-Gt(ROSA)26Sortm1(CAG-Bcl2)Zhu/J | Rosa26 |
These Rosa26LSL-Bcl2 express a Cre-inducible Bcl2 gene and are useful when testing cancer models and when studying cell death during T-cell development. |
038290 | C57BL/6-Ntsr1tm1.1Kff/BouvJ | NTSR1-Venus | NTSR1-Venus reporter mice have the neurotensin receptor 1 gene driving expression of a Venus yellow fluorescent protein. These mice may be useful as a means for visualizing receptor neuroanatomy and real-time receptor trafficking in live neurons. |
038302 | C57BL/6-Ackr3tm1.1Kff/BouvJ | Ackr3-Venus | ACKR3-Venus/Venus reporter mice have the atypical chemokine receptor 3 gene driving expression of a Venus yellow fluorescent protein. These mice may be useful as a means for visualizing receptor neuroanatomy and real-time receptor trafficking in live neurons. |
038300 | B6.Cg-Tg(Dct-rtTA2S*M2)B8Mrln Tg(tetO-HIST1H2BJ/GFP)47Efu/J | iDct-GFP , Dct-rtTA/TRE-H2B-GFP | iDct-GFP mice target tetracycline/doxycycline-inducible green fluorescent protein (GFP) expression to melanocytes during all embryonic, neonatal, and adult developmental stages. This enables the sorting, tracking, and study of melanocytes, their associated diseases, and the development of melanoma when crossing with strains carrying melanomagenesis alleles. |
038306 | 129S4/SvJae-Gt(ROSA)26Sortm7Sor/J | ROSA26 |
ROSA26SAE translocation sensor mice conditionally express fluorescent ERK1/2 pathway and nuclear reporters from a single Gt(ROSA)26Sor transcript, enabling live-cell in vivo (whole embryo or animal) and ex vivo (cell line) studies of intracellular signaling in response to external stimuli. |
038307 | 129S4/SvJae-Gt(ROSA)26Sortm8Sor/J | ROSA26 |
ROSA26SAT translocation sensor mice conditionally express fluorescent ERK1/2 pathway, ATK pathway, and nuclear reporters from a single Gt(ROSA)26Sor transcript, enabling live-cell in vivo (whole embryo or animal) and ex vivo (cell line) studies of intracellular signaling in response to external stimuli. |
038390 | B6.Cg-Tg(KRT14-cre/ERT2)1Ipc/AkinJ | K14-Cre-ER |
K14-Cre-ERT2 mice express a tamoxifen-inducible Cre recombinase/ERT2 fusion under the control of the human keratin K14 (KRT14) promoter/enhancer. Cre recombinase activity is observed in the basal layer of stratified squamous epithelia. This strain may be useful tool in studies of the epidermis. |
038428 | B6.129S4(Cg)-Tsc1tm1Djk/MhnyJ | Tsc1 |
These Tsc1c floxed mice possess loxP sites flanking exons 17 and 18 of the Tsc1 gene. This mutant strain may be useful in tissue-specific studies including tuberous sclerosis or other hamartoma syndromes, regulation of the actin cytoskeleton and motility, cellular and organismal glucose homeostasis, cell growth responses, apoptosis regulation, and regulation of cell size. Specifically on this congenic C57BL/6J background, mice are useful for creating a mouse model of chronic epilepsy. |
038492 | C57BL/6-Bmp10tm1(cre/ERT2)Fwin/J | Bmp10-CreER |
Bmp10-CreERT2 are knock-in mice with an inducible cre/ERT2 fusion gene inserted into the bone morphogenetic protein 10 (Bmp10) gene. BMP10 is expressed in the hepatic stellate cells (HSCs) of the liver. These mice can be used as research tool to study liver fibrosis. |
038523 | C57BL/6N-Il1rl2tm1.1Llsm/J | IL-36R |
IL-36Rfl mice possess loxP sites flanking exon 3 of the Il1rl2 (interleukin 1 receptor-like 2 or IL-36R) gene. These floxed mice are useful for tissue specific deletion of IL-36R when studying inflammation and allergic diseases. |
038286 | C57BL/6J-Pcbp1em8Salr/J | Pcbp1 |
Pcbp1Flox mice possess loxP sites flanking the entire coding region of the poly(rC) binding protein 1 (Pcbp1) gene. These mice may be useful for studying the role of Pcbp1 in transcription and translational processes, cell proliferation and differentiation, as well as multiple cancers. |
037699 | C57BL/6J-Piezo1em1Macki/J | PIEZO1-HA-knock-in | PIEZO1-HA-knock-in mice express a hemagglutinin-tagged form of PIEZO1 (piezo-type mechanosensitive ion channel component 1) that is useful for detecting the protein on cell surfaces. |
038287 | B6.Cg-Pcbp2tm1.1Salr/J | Pcbp2 |
Pcbp2Flox mice possess loxP sites flanking the promoter region and exons 1-2 of the poly(rC) binding protein 2 (Pcbp2) gene. These mice may be useful for studying the regulatory role of Pcbp2 in transcription and translational processes, cell proliferation and differentiation, as well as the oncogenic effects of Pcbp2 in multiple cancers. |
038628 | STOCK Pdgfratm2.1(flpo)Leol Gt(ROSA)26Sortm65.2(CAG-tdTomato)Hze/LeolJ | Pdgfra |
PdgfraFlp;fSf-Tomato mice have a floxed cassette containing both a cDNA encoding the Pdgfra gene and a flpo sequence replacing exons 2-4 of the endogenous Pdgfra gene. Mice also contain a conditional tdTomato fluorescent FLP reporter allele, Ai65F or fSf-Tomato. Cre recombination leads to the knock-out of Pdgfra expression and Flp/FRT-mediate intersectional lineage tracing of cre-expressing cells and their progeny. |
038641 | C57BL/6J-Rps12em1Nbakr/J | RpS12 |
Exons 2 and 3 of the mouse ribosomal protein S12 (Rps12) gene are flanked by loxP sites in these Rps12flox mice. Cre recombinase-mediated excision of the floxed region creates a knock-out allele useful in studies of Diamond-Blackfan Anemia (DBA) and ribosomal protein (Rp) function. |
033000 | 129S4/SvJaeSorJ | This substrain of 129, from the steel group of 129 substrains (129S), is a common source of embryonic stem cell lines used in development of targeted mutations. The 129S4/SvJaeSor inbred strain, separated from the 129S4/SvJae parental subline in 1987, has been used to develop multiple embryonic stem cell lines including: AK7, AK7.1, and AK18.1. |
|
038037 | STOCK Sftpa1tm1Haw Tg(SFTPC-SFTPA2*)T4Jflo/Mmjax | SP-A2 (1A3) T4 | SP-A KO hTG SP-A2 mice express human SFTPA2 (surfactant associated protein A2 or SP-A2) variant 1A3 under the control of the human SFPTC promoter on a Sftpa1 null background. This strain may be useful for studying lung function, surfactant structure, host defense and inflammation. |
038038 | STOCK Sftpa1tm1Haw Tg(SFTPC-SFTPA1*)T4Jflo/Mmjax | SP-A1 (6A4) T4 | SP-A KO hTG SP-A1 mice express the human SFTPA1 (surfactant associated protein A1 or SP-A1) variant 6A4 under the control of the human SFPTC promoter on a Sftpa1 null background. This strain may be useful for studying lung function, surfactant structure, host defense and inflammation. |
038039 | STOCK Sftpa1tm1Haw Tg(SFTPC-SFTPA1*)T3Jflo/Mmjax | SP-A1 (6A2) T3 | SP-A KO hTG SP-A1 mice express the human SFTPA1 (surfactant associated protein A1 or SP-A1) variant 6A2 under the control of the human SFPTC promoter on a Sftpa1 null background. This strain may be useful for studying lung function, surfactant structure, host defense and inflammation. |
036954 | B6.Cg-Xpatm1Hvs Ercc8em1(IMPC)H/Mmjax | Mice carrying knock-out alleles of Xpa (xeroderma pigmentosum, complementation group A) and Ercc8 (excision repaiross-complementing rodent repair deficiency, complementation group 8, also known as Csa) are combined to generate a mouse model of Cockayne syndrome, a multisystem disorder characterized by segmental progeria, growth failure, lipodystrophy, neurologic abnormalities, and severe photosensitivity. |
|
038031 | STOCK Del(11Hnf1b-Znhit3)11Moro/Mmjax | 17q12Del | 17q12Del mice have a 1.2 Mb deletion on syntenic mouse chromosome 11qC. 17q12 deletion syndrome is associated with neurodevelopmental disorders and renal cysts and diabetes syndrome (RCAD). The 17q12Del mouse phenocopies several features of the human disorder including, craniofacial and brain malformations in deletion mice, along with renal and diabetes phenotypes. |
038460 | B6129S-Syngap1em1Rlh/Mmjax | Syngap1 |
Syngap1L813RfsX22 mice have a frameshift mutation resulting in a premature stop codon in the Syngap1 [synaptic Ras GTPase activating protein 1 homolog (rat)] gene. Heterozygous mice display impaired synaptic plasticity, hyperactivity, and impaired working memory. This strain may be useful in studies of SRID (SYNGAP1-related intellectual disability). Of note, mice with another patient-derived Syngap1 mutation (c.3583-9G>A) is distributed as B6;129-Syngap1em2Rlh/Mmjax, MMRRC No. 071392). |
038461 | B6129S-Syngap1em2Rlh/Mmjax | Syngap1 |
Syngap1c.3583-9G>A mice have a single base substitution resulting in a cryptic splice acceptor site and premature stop codon in the Syngap1 [synaptic Ras GTPase activating protein 1 homolog (rat)] gene. Heterozygous mice display impaired synaptic plasticity, hyperactivity, and impaired working memory. This strain may be useful in studies of SRID (SYNGAP1-related intellectual disability). Of note, mice with another patient-derived Syngap1 mutation (L813RfsX22) is distributed as B6;129-Syngap1em1Rlh/Mmjax, MMRRC No. 071391). |
036755 | C57BL/6J-Slc6a1em1Lutzy/Mmjax | B6J.LSL_Slc6a1 | Slc6a1em1Lutzy is a CRISPR/cas9 generated mutant of the Slc6a1 (solute carrier family 6 (neurotransmitter transporter, GABA), member 1) gene carrying a loxP-flanked STOP (LSL) in intron 6. The LSL prevents expression of Slc6a1, creating a reversible null allele. These mice may be
useful in studies of molecular mechanisms of GABA inhibitory neurotransmission. |
034602 | C57BL/6J-Kcnn3em1Lutzy/Mmjax | Kcnn3 |
Kcnn3V556F conditional knock-in/knock-out mice carry a lox-stop-lox (LSL) inserted upstream of the clinical V556F gain of function mutation in the Kcnn3 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) gene. The insertion of the LSL cassette is believed to result in a null allele. These mice may be useful in studying Zimmermann–Laband Syndrome (VLS). Mice expressing the V556F mutation are available as B6J(CBA)-Kcnn3em1.1Lutzy/Mmjax (MMRRC Stock No. 071601). |
034605 | B6J(CBA)-Kcnn3em1.1Lutzy/Mmjax | Kcnn3 |
Kcnn3V556F knock-in mice express the clinical V556F gain of function mutation in the Kcnn3 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) gene. These mice may be useful in studying Zimmermann–Laband Syndrome (VLS). Mice with conditional expression of the V556F mutation are available as C57BL/6J-Kcnn3em1Lutzy/Mmjax (MMRRC Stock No. 071600). |
017961 | STOCK Dscamtm1Pfu/RwbJ | Dscam |
DscamF mice possess loxP sites flanking the transmembrane encoding exon of the DS cell adhesion molecule (Dscam) gene. These floxed mice are useful for tissue specific deletion of Dscam when studying cell body spacing, developmental cell death and retinal development. |
035178 | STOCK Raratm1.1Sud/J | HA-RARalpha KI | HA-RARalpha KI knock-in mice express hemagglutinin-tagged mouse RARA (retinoic acid receptor, alpha) protein. Cre recombinase-mediated excision of floxed exons 4 and 5 results in the production of hemagglutinin-tagged RARA protein lacking the DNA binding domain. |
035697 | B6.Cg-Saa3em1Litt Del(7Saa1-Saa2)1Itl/J | SAA |
SAATKO mice carry a triple knock-out of mouse genes Saa1, Saa2, and Saa3, all of which are on Chromosome 7. This strain has been useful in studies of pathogenic Th17 cell involvement in inflammatory disease. |
036257 | STOCK Prcptm1.1Sdno/J | Prcp |
Prcpfl/fl mice have loxP sites flanking exon 4 of the Prcp gene. These mice are useful for studying the role of PRCP in the regulation of metabolism, hypertension, food intake and mood disorders. |
036770 | B6.Cg-Tg(Gm5127-cre/ERT2)1Mhsi/J | Gm5127(BAC)CreERT2 | Gm5127(BAC)CreERT2 transgenic mice express a tamoxifen inducible Cre recombinase/ERT2 fusion under the control of the mouse Gm5127 promoter elements. Cre recombinase activity is observed specifically in venous endothelial cells. This strain may be useful in studies of angiogenesis, and specifically, in fate mapping of venous endothelial cells in the brain and retinal and dermal vascular in postnatal and adult mice stages. |
037204 | B6;129-Omptm1Feins/RmncJ | OMP-H2B::mCherry | OMP-H2B::Cherry knock-in/knock-out mice may be useful for visualization of mature olfactory sensory neurons. |
037667 | C57BL/6J-Kcnc3em1Jt/J | Kcnc3 |
Kcnc3G434V mice carry a CRISPR/Cas9-generated missense mutation in the mouse Kcnc3 (potassium voltage gated channel, Shaw-related subfamily, member 3) gene. The mutation decreases the activity of hippocampal neurons and causes defects in learning and memory in a fear-conditioning task. |
037825 | B6.129-P2ry6tm1Jabo/J | P2ry6 |
P2ry6fl/fl floxed mice have loxP sites flanking exon 3 of the P2ry6 gene. These mice may be useful when studying inflammatory responses. |
037852 | B6(Cg)-Nr1d1tm1.1Laz/J | Rev-erbα |
Rev-erbαfl mice have loxP sites flanking exons 3-5 of the Nr1d1 gene. These mice may be useful when studying the circadian clock and its effects on metabolism. |
037893 | C57BL/6-Tg(Prnp-ITM2B*)7Jckr/J | ADanPP | ADanPP mice contain the Danish 10-nucleotide insertion (TTTAATTTGT) mutation in the human Itm2b gene under direction of the Prnp promoter and may be useful for studying amyloid deposition associated with Familial Danish dementia (FDD) synaptic dysfunction. |
037963 | CBA.Cg-Ssttm2.1(cre)Zjh/AhsnJ | Sst-IRES-Cre | Sst-IRES-Cre knock-in mice express Cre recombinase in somatostatin-expressing neurons. These mice may be useful in studying dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells. While Sst-IRES-Cre was designed as a 3' knock-in allele, additional characterization indicates it has significantly diminished endogenous Sst expression - see details below. As such, researchers should consider using heterozygous Sst-IRES-Cre mice and wildtype littermate controls in all their studies. Of note, the same Sst-IRES-Cre knock-in allele is also available on a C57BL/6J genetic background as Stock No. 028864, a C57BL/6N genetic background as Stock No. 018973, and a STOCK background as Stock No. 013044. |
037964 | CBA.Cg-Viptm1(cre)Zjh/AhsnJ | Vip-IRES-cre | Vip-IRES-Cre mice have Cre recombinase expression directed to Vip-expressing cells by the endogenous promoter/enhancer elements of the vasoactive intestinal polypeptide locus. Cre activity is detected in the neocortex, hippocampus, olfactory bulb, suprachiasmatic nuclei, and other discrete midbrain and brainstem regions. These mice may be useful to study neural GABAergic circuits throughout the mammalian brain. While Vip-IRES-Cre was designed to retain endogenous Vip expression, a 2019 publication indicates this allele has reduced Vip expression - see details below. As such, researchers may use homozygous mice for routine colony maintenance, but should consider using heterozygous Vip-IRES-Cre mice and wildtype littermate controls in all their studies. Of note, the same Vip-IRES-Cre knock-in allele is also available on a C57BL/6J genetic background as Stock No. 031628 and a STOCK background as Stock No. 010908. |
038008 | C.Cg-Plpp6tm1Bdl/J | Plpp6<-> | Plpp6 knock-out mice have the coding region of the Plpp6 (phospholipid phosphatase 6) gene replaced by a neomycin cassette. Homozygous null mice have reduced levels of cholesterol and a decreased response to induced allergic lung inflammation. This strain may be useful for studies involving cholesterol regulation, dendritic cell macropinocytosis, and allergen-induced lung inflammation. |
038129 | B6.Cg-Ascl3tm2.1(EGFP/Cre/ERT2)Ovi/J | Ascl3 |
Ascl3P2A-GCE knock-in mice express an eGFP/CreERT2 fusion protein in achaete-scute family bHLH transcription factor 3 (Ascl3)-expressing cells while retaining endogenous Ascl3 activity. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre recombinase activity is detected in the Ascl3-expressing cells of the offspring. Of note, the donating investigator has indicated that eGFP expression is not detectable either by direct fluorescence or immunohistochemistry. |
038171 | C57BL/6-Tg(Myh6-TFRC/OVA)#Ahlm/J | CMy-mOva | CMy-mOva mice express an V5- and His6-tagged cardiac myocyte restricted membrane-bound ovalbumin under the control of the Myh6 promoter. Hemizygous mice are tolerant to ovalbumin. This strain may be useful for research involving viral infections and cardiomyopathy. |
038238 | FVB/NJ-mtC57BL/6J/DrweJ | FC | FC (FVB/NJ-mtMNX(C57BL/6J)) is a conplastic strain in which the FVB/NJ strain carries the mitochondrial genome from C57BL/6J. This strain can be used for studies of complex diseases that have quantitative trait loci (QTL) identified in mitochondrial DNA. Of note: FB (FVB/NJ-mtMNX(BALB/cJ)) is distributed as FVB/NJ-mtBALB/cJ/DrweJ, Stock No. 038429. This strain carries the mitochondrial genome from BALB/cJ on the FVB/NJ host. |
038245 | C57BL/6NJ-Tbr1em1Boro/J | Tbr1-A136Pfs | Tbr1-A136fs knock-in mice carry a CRISPR/Cas9-generated frameshift mutation in the T-box brain transcription factor 1 (Tbr1) locus, which corresponds to the clinical mutation A136Pfs*80. These mice may be useful for studying neurodevelopmental disorders such as autism spectrum disorder (ASD). |
038288 | B6;SJL-Runx1em1Salr/J | Runx1-ΔE6 | Runx1-ΔE6 mice express a CRISPR-generated exon 6 splice variant of the runt related transcription factor 1 (Runx1) gene, which results in production of a mutant protein that lacks exon 6 encoded amino acids. These mice may be useful for studying the role of Runx1 in hematopoietic cell development and disorders, such as leukemias. |
038296 | B6.129S1(SJL)-Fezf2tm1.1Nses/J | Fezf2 |
Fezf2flox/flox mutant mice possess loxP sites flanking exon 2 of the Fez family zinc finger 2 gene. This strain may be useful for studying corticospinal motor neuron projections and immune tolerance. |
038297 | C57BL/6J-Rnd3em1Nses/J | Rnd3 |
Rnd3fl/fl mice carry a CRISPR/Cas9 generated mutation that results in loxP sites flanking exon 3 of the Rho family GTPase 3. This strain may be useful for studying corticospinal motor neuron projections and axon guidance. |
038336 | B6(CBA)-Pcdhgem3Rwb/JaweJ | Pcdhg |
PcdhgC3KO mice carry a CRISPR/Cas9-generated mutation in the Pcdhgc3 gene within the protocadherin gamma cluster (Pcdhg) on chromosome 18, making this strain useful when studying studying neuronal structure and function of hypothalamic neuronal circuitry. |
038346 | B6.129-Ptk6tm1Aty/J | Ptk6<-> | Ptk6-/- mice have a neomycin resistance (neo) cassette replacing the transcription start site and the first exon of the PTK6 protein tyrosine kinase 6 (Ptk6) gene, abolishing endogenous gene expression. These mice may be useful for studying the regulation of growth and differentiation in normal epithelial cells as well as tumor cells. |
038350 | C57BL/6J-Txnipem1Ngwu/J | NTX | NTX mice express a CRISPR-generated N-terminal double HA-tagged protein under direction of the endogenous thioredoxin interacting protein (Txnip) promoter. These mice may be useful for evaluating TXNIP localization patterns and function in glucose homeostasis, adipogenesis and energy metabolism. |
038371 | D2.Cg-Tg(DMD*)#Spc Dmdmdx/J | hDMD(del45) mdxD2 | The hDMD(del45) mdxD2 strain harbors both a mutant human DMD (dystrophin, muscular dystrophy) transgene, del45, and mouse Dmd knock-out allele. These mice may be useful for studying Duchenne and Becker muscular dystrophies. Our preclinical efficacy testing services offer scientific expertise and an array of target-based and phenotype-based outcome measures, both in vivo and at endpoint, for flexible study designs and assay development in mouse models of Muscular Dystrophy. See our full service platform. |
038374 | C57BL/6NJ-Nntem1Asuh/J | 6N<ΔNnt8-12> | 6NΔNnt8-12 knock-out (KO) mice contain a CRISPR/Cas9 generated deletion of exons8-12 of the nicotinamide nucleotide transhydrogenase (Nnt) gene on a C57BL/6NJ genetic background. This strain may be useful for studying the role of Nnt in reduction/oxidation-dependent processes and mitochondrial dysfunction. |
038375 | C57BL/6J-Gzmaem1Asuh/J | Gzma |
GzmaS211A knock-in mice contain a CRISPR/Cas9 generated insertion of the S211A point mutation in granzyme A (Gzma) gene, resulting in a loss of GZMA enzymatic function. This strain may be useful for studying cell-mediated cytotoxicity. |
038377 | C57BL/6J-Ace2em1Asuh/J | mACE2<-> | mACE2- knock-out (KO) mice carry a CRISPR/Cas9-generated deletion of the entire angiotensin converting enzyme 2 (Ace2) gene. In humans, ACE2 is the receptor used for cellular entry by several coronaviruses, including severe acute respiratory syndrome coronavirus-1 (SARS-CoV) and -2 (SARS-CoV-2). This strain may be useful as a mouse null control for the study of 2019 novel coronavirus (SARS-CoV-2) pathogenesis. JAX is dedicated to supporting the scientific community in its response to the COVID-19 pandemic. View our portfolio of available models for SARS-CoV-2 research. |
038378 | C57BL/6J-Serpinb2em1Asuh/J | SerpinB2 |
SerpinB2R380A knock-in (KI) mice contain a CRISPR/Cas9 generated insertion of the R380A (arginine>alanine) mutation in the serine (or cysteine) peptidase inhibitor, clade B, member 2 (Serpinb2) gene, resulting in a loss of enzymatic function. This strain may be useful for studying the regulatory role of Serpinb2 in plasminogen activation, cell migration and immune response pathways. |
038391 | B6.129S2(Cg)-Bcl11atm1.2Leid/J | Ctip1 |
Bcl11aL2 (or Ctipfl) mice possess loxP sites flanking exons 3-4 of the Bcl11a (B cell CLL/lymphoma 11A [zinc finger protein], also known as Ctip1) gene. These floxed mice are useful for tissue specific deletion of Bcl11a when studying skin disorders. |
038429 | FVB/NJ-mtBALB/cJ/DrweJ | FB | FB (FVB/NJ-mtMNX(BALB/cJ)) is a conplastic strain in which the FVB/NJ strain carries the mitochondrial genome from BALB/cJ. This strain can be used for studies of complex diseases that have quantitative trait loci (QTL) identified in mitochondrial DNA. Of note: FC (FVB/NJ-mtMNX(C57BL/6J)) is distributed as FVB/NJ-mtC57BL/6/DrweJ, Stock No. 038238. This strain carries the mitochondrial genome from C57BL/6J on the FVB/NJ host. |
038462 | C57BL/6J-Atoh1em2Zyliu/J | Atoh1*3xV5-P2A-tdTomato | Atoh1-3*V5-P2A-Tdtomato mice have a CRISPR/Cas9-generated 3xV5 epitope tag and P2A-tdTomato cassette inserted into the C terminus of the atonal bHLH transcription factor 1 (Atoh1) gene. These mice are useful for visualizing inner hair cells (IHCs) and outer hair cells (OHCs) of the organ of Corti (OC) and as a tool for sorting pure neonatal cochlear HCs. |
038463 | C57BL/6J-Ikzf2em1Zyliu/J | Ikzf2*3xV5-P2A-tdTomato | Ikzf2-3*V5-P2A-Tdtomato mice have a CRISPR/Cas9-generated 3xV5 epitope tag and P2A-tdTomato cassette fused to the C terminus of the IKAROS family zinc finger 2 (Ikzf2) gene. These mice are useful for visualizing outer hair cells (OHCs) of the organ of Corti (OC). |
038465 | C57BL/6-Dock3em1Msalx/J | Dock3 |
Dock3fl/fl mice carry a CRISPR/Cas9 generated mutation that results in loxP sites flanking exons 8-9 of the dedicator of cyto-kinesis 3 (Dock3) gene. These mice may be useful when studying neurodegeneration and metabolic dysregulation in skeletal muscle. |
038489 | B6;129-Ces1dtm2Rile/J | Ces1d |
Ces1dFlox mice possess loxP sites flanking exon 5 of the carboxylesterase 1D (Ces1d) gene. These mice may be useful for generating conditional mutants to study the role of Ces1d in lipid metabolism and drug metabolism. |
038493 | STOCK Nde1tm1Caw/YfngJ | Nde1<-> | Nde1-/- mice have exon 2 of the nudE neurodevelopment protein 1 gene removed, abolishing expression. These mice may be useful for studying microtubule organization, mitosis, neuronal migration, and cerebral cortex size. |
038497 | C57BL/6J-Rorcem1(Thy1)Aben/J | Rorc |
RorcThy1.1 knock-in mice have the thymus cell antigen 1, theta (Thy1.1) sequence inserted into the 3' UTR of the Rorc locus, while retaining endogenous Rorc expression. This strain may be useful as a reporter for studying Rorc expression in T cell and innate lymphoid cell lineages. |
038550 | C57BL/6J-Pacs1em2Gath/J | PACS1 |
PACS1R201W conditional knock-in mice carry an R201W amino acid substitution preceded by a lox-STOP-lox (LSL) cassette in the Pacs1 (phosphofurin acidic cluster sorting protein 1) gene. This strain may be useful for research in neurodevelopmental disorders such as PACS1 syndrome.
Of note, the mutant R203W human PACS1 gene is distributed as C57BL/6J-Gt(ROSA)26Sorem2(CAG-PACS1)Gath/J (Stock No. 038551). In addition, the the human PACS1 control is distributed as C57BL/6J-Gt(ROSA)26Sorem2(CAG-PACS1)Gath/J (Stock No. 038552). |
038551 | C57BL/6J-Gt(ROSA)26Sorem1(CAG-PACS1*R203W)Gath/J | R26 |
R26P1R203W knock-in mice have conditional, widespread expression of the human PACS1 (phosphofurin acidic cluster sorting protein 1) gene with the human R203W variant associated with with developmental delay and intellectual disability (PACS1 syndrome). This strain may be useful for studies involving research in neurodevelopmental disorders such as PACS1 syndrome.
Of note, the wild-type human PACS1 gene is distributed as C57BL/6J-Gt(ROSA)26Sorem2(CAG-PACS1)Gath/J (Stock No. 038552). In addition, the orthologous mouse R201W mutation knocked in to the mouse Pacs1 locus is distributed as C57BL/6J-Pacs1em2Gath/J (Stock No. 038550). |
038552 | C57BL/6J-Gt(ROSA)26Sorem2(CAG-PACS1)Gath/J | R26 |
R26P1 knock-in mice have conditional, widespread expression of the human PACS1 (phosphofurin acidic cluster sorting protein 1) gene. This strain may be useful for studies involving research in neurodevelopmental disorders such as PACS1 syndrome.
Of note, the mutant R203W human PACS1 gene is distributed as C57BL/6J-Gt(ROSA)26Sorem2(CAG-PACS1*R203W)Gath/J (Stock No. 038551). In addition, the orthologous mouse R201W mutation knocked in to the mouse Pacs1 locus is distributed as C57BL/6J-Pacs1em2Gath/J (Stock No. 038550). |
038570 | B6.Cg-Flrt2em1Jnk/J | FLRT2 |
FLRT2UF mice carry a point mutation that disrupts interactions between fibronectin leucine rich transmembrane protein 2 (FLRT2) and its ligands of the unc-5 netrin receptor family (UNC5A, UNC5B, UNC5C, and UNC5D). This strain has been useful in studies of selective synaptic partnering by neurons and FLRT2-UNC5 signaling. |
038571 | STOCK Ndufs2tm1.1Job Tg(CAG-cre/Esr1*)5Amc/J | Inducible MCI-PARK | Inducible MCI-PARK mice, based on the ESR-NDUFS2 strain described by Fernández-Agüera, 2015 (PMID: 26437605), were generated through an intercross of mice carrying a floxed allele of mouse NADH:ubiquinone oxidoreductase core subunit S2 (Ndufs2; derived from Stock No. 036313) with animals that broadly express tamoxifen-inducible cre recombinase (Tg(CAG-cre/Esr1*)5Amc; Stock No. 004682). Induction with tamoxifen creates a conditional knock-out of Ndufs2, useful in studies of Parkinson’s disease (PD). Distribution of this double mutant strain (Stock No. 038571) was supported by the Michael J. Fox Foundation for Parkinson's Research. |
038572 | B6.Cg-Gt(ROSA)26Sortm1.1(CAG-Mfsd2a)Chgu/J | R26 |
R26LSL-Mfsd2a mice enable conditional, Cre recombinase-dependent overexpression of mouse MFSD2 lysolipid transporter A, lysophospholipid (Mfsd2a) upon excision of a loxP-flanked Stop cassette. This strain has been useful in studies of neurovascular coupling. |
038578 | C57BL/6J-Gpr182em1Thln/J | GPR182 |
GPR182mCherry knock-in/knock-out mice contain a CRISPR/Cas9-generated insertion of mCherry replacing the entire coding region of the Gpr182 gene. These mice may be useful for tracking expression of the atypical chemokine receptor (ACKR), GPR182, and for studying its role as a chemokine scavenger. |
038581 | B6(129)-Creb5em1Alb/J | Creb5 |
Creb5flox9/flox9 mice carry a CRISPR/Cas9 generated mutation that results in loxP sites flanking exon 9 of the cAMP responsive element binding protein 5 (Creb5) gene. These mice may be useful when studying synovial joint formation and the development of articular chondrocytes. |
038582 | STOCK Fbxo2tm1.1(cre/ERT2)Akg/J | Fbxo2 |
Fbxo2CreERT2 knock-in/knock-out mice express a CreER fusion protein driven by the F-box protein 2 (Fbxo2) endogenous promoter, while abolishing endogenous Fbxo2 expression. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Fbxo2-expressing cells of the offspring. These mice may be useful when studying inner ear sensory epithelial cells. |
038583 | STOCK Gt(ROSA)26Sorem1(CAG-Atoh1/EGFP)Akg/J | ROSA-A | ROSA-A knock-in mice have a CRISPR/Cas9 generated insertion of a floxed STOP cassette and Atoh1 sequence fused to an enhanced green fluorescent protein (eGFP) inserted into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in ATOH1/eGFP expression in Cre expressing tissues. These mice may be useful for the labeling and isolation of Atoh1-expressing neurons, auditory hair cells, skin cells and secretory cells in the gut. |
038584 | STOCK Gt(ROSA)26Sorem2(CAG-Gf1i,-Atoh1/EGFP)Akg/J | ROSA-GA | ROSA-GA knock-in mice have a CRISPR/Cas9 generated insertion of a floxed STOP cassette, followed by an Gfi1 sequence and a Atoh1 sequence fused to an enhanced green fluorescent protein (eGFP), into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in co-expression of the transcription factors GFI1 and ATOH1/eGFP in cre-expressing tissues. These mice may be useful for evaluating overexpression of GFI1 and ATOH1 in neuronal and auditory hair cell development, differentiation and regeneration. |
038585 | STOCK Gt(ROSA)26Sorem3(CAG-Gf1i,-Atoh1/EGFP,-Pou4f3)Akg/J | ROSA-GAP | ROSA-GAP knock-in mice have a CRISPR/Cas9 generated insertion of a floxed STOP cassette, followed by a Gfi1 sequence, an Atoh1 sequence fused to an enhanced green fluorescent protein (eGFP) and a Pou4f3 sequence, into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in co-expression of the transcription factors GFI1, ATOH1/eGFP and POU4F3 in cre-expressing tissues. These mice may be useful for evaluating overexpression of GFI1, ATOH1 and POU4F3 in neuronal and auditory hair cell development, differentiation and regeneration. |
038586 | STOCK Foxi3em1Akg/J | Foxi3 |
Foxi3GFP knock-in mice carry an mVenus fluorescent reporter inserted immediately downstream of the Foxi3 coding region, while retaining endogenous Foxi3 expression. This strain may be useful as a reporter for tracking Foxi3-expressing cells during embryogenesis; specifically, neuroepithelial cells, pharyngeal arches and pouches, as well as hair and tooth progenitor cells. The donating laboratory has also made a Foxi3CreER knock-in/knock-out mouse line available as Stock No. 038587. |
038587 | STOCK Foxi3em2(cre/ERT2)Akg/J | Foxi3 |
Foxi3CreER knock-in/knock-out mice have a CreER fusion protein driven by the Foxi3 endogenous promoter, while abolishing endogenous Foxi3 expression. This strain may be useful for Cre-lox studies of Foxi3-expressing cells during embryogenesis; specifically, neuroepithelial cells, pharyngeal arches and pouches, as well as hair and tooth progenitor cells. Although eGFP is also present in this Foxi3CreER allele, its low level of expression from the construct did not allow detection of the eGFP protein, either by native fluorescence or by immunostaining with GFP antibodies. The donating laboratory has also made a Foxi3 reporter line available that retains endogenous Foxi3 expression: Foxi3GFP (Stock No. 038586). |
038596 | C57BL/6-Traf7tm1.1Ifd/J | Traf7 |
Exons 2-14 of the mouse TNF receptor-associated factor 7 (Traf7) gene are flanked by loxP sites in these Traf7fl conditional mutant mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele, useful in studies of vascular development and integrity. |
038627 | STOCK Pdgfratm1.1(flpo)Leol Gt(ROSA)26Sortm65.2(CAG-tdTomato)Hze/LeolJ | Pdgfra |
PdgfraK.Flp;fSf-Tomato knock-in/knock-out mice have a floxed stop cassette and cDNA encoding a constitutively active Pdgfra gene (D842V; PDGFRαK) with a T2A-flpo sequence replacing the PDGFRαK stop codon. Mice also contain a conditional tdTomato fluorescent FLP reporter allele. Cre recombination leads to the activation of PDGFRA kinase activity and Flp/FRT-mediated lineage tracing in cre-expressing cells. |
038629 | STOCK Gt(ROSA)26Sortm65.2(CAG-tdTomato)Hze Pdgfrbtm1.1(flpo)Leol/LeolJ | Pdgfrb |
PdgfrbFlp;fSf-Tomato mice have a floxed cassette containing both a cDNA encoding the Pdgfrb gene and a flpo sequence replacing exons 2-4 of the endogenous Pdgfrb gene. Mice also contain a conditional tdTomato fluorescent FLP reporter allele, Ai65F or fSf-Tomato. Cre recombination leads to the knock-out of Pdgfrb expression and Flp/FRT-mediated intersectional lineage tracing of cre-expressing cells and their progeny. |