First Look Strains

Stock Number	Name	Common Name	Description
030131	C57BL/6NJ-Gnb1^em2Frk/J	Gnb1	Gnb1^D76G knockin mice express the D76G (aspartic acid to glycine) amino acid substitution in the Gnb1 (guanine nucleotide binding protein (G protein), beta 1) locus. The mutation results in homozygous perinatal or embryonic lethality. The mutation is associated with neurodevelopmental disease and lymphocytic abnormalities.
031869	B6N(129S4)-A1cf^{tm1c(EUCOMM)Hmgu}/Rkor	A1cf	A1cf^FL mice have exon 4 of the APOBEC1 complementation factor (A1cf) gene, floxed, making these mice useful for studying RNA binding proteins and metabolic regulation.
032637	B6;DBA-Tg(Myl1-rtTA2S*M2)1Lach/J	MDAFrtTA	MDAFrtTA mice are a Tet-On tool that allows conditional, doxycycline-inducible expression of the reverse tetracycline-controlled transactivator (rtTA) protein in skeletal muscle using the rat myosin light chain (Myl1) promoter.
032865	C57BL/6N-Gnb1^em5Frk/J	Gnb1	Gnb1^K78R knock-in mice carry a CRISPR/Cas9-generated K78R missense mutation in the mouse Gnb1 (guanine nucleotide binding protein (G protein), beta 1) gene that is homologous to a human mutation associated with GNB1 Encephalopathy. Heterozygous mice recapitulate many aspects of the disorder, including developmental delay, motor and cognitive deficits, and absence-like generalized seizures. Homozygotes are embryonic lethal.
033836	B6.Cg-Ano2^tm1Lyj/HyngJ	TMEM16B KO	TMEM16B KO mice have a C terminus farnesylated mCherry (mCherry-F) sequence in frame at the alternative start ATG in exon 3 of the anoctamin 2 (Ano2) gene. These mice are useful when studying inferior olivary neuron excitability and cerebellar motor learning.
035959	NOD.Cg-Gt(ROSA)26Sor^{em27(KRT18-ACE2)Mvw} Prkdc^scid Il2rg^tm1Wjl/MvwJ	NSG.RMCE[K18-HuACE2]	NSG.RMCE[K18-HuACE2] mice are NOD.scid.Il2Rγc^null ("NSG") animals expressing human ACE2, the receptor used by severe acute respiratory syndrome coronavirus (SARS-CoV) to gain cellular entry. The human keratin 18 promoter directs expression to epithelial cells, including airway epithelia where infections typically begin. Human ACE2 is the receptor used for cellular entry by several coronaviruses, including severe acute respiratory syndrome coronavirus-1 (SARS-CoV), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2; 2019 novel coronavirus) and HCoV-NL63. This hACE2-KI mouse model may be useful in studying antiviral therapies for these coronaviruses, particularly SARS-CoV-2 pathogenesis and the disease outbreak COVID-19. With the severe immunodeficiency of NSG, NSG hACE2-KI mice may exhibit reduced immune response and increased susceptibility to SARS-CoV viral infection during clinical trials. JAX is dedicated to supporting the scientific community in its response to the COVID-19 pandemic. View our portfolio of available models for SARS-CoV-2 research.
036159	B6J.Cg-Gba^em1Mcook/J	Gba	Gba^E326K mice carry a CRISPR/Cas9-generated E326K knock-in in exon 8 of the mouse Gba (glucosidase, beta, acid) gene. This mutation corresponds to a human coding variant potentially associated with increased susceptibility to familial Parkinson's disease. Homozygotes show ~30-40% reduction in glucocerebrosidase (GCase) activity in whole brain tissue as well as a decrease in the total protein.
036181	NOD.Cg-Gt(ROSA)26Sor^em5Mvw/MvwJ	NOD.RosaBxb-GT/GA	NOD.RosaBxb-GT/GA mice are a resource for the rapid creation of vector-free targeted alleles in the Gt(ROSA)26Sor locus on the NOD/ShiLtJ background. The dual Bxb1 attP-site "safe harbor landing pad" in the first intron of Gt(ROSA)26Sor enables efficient and precise integration of a donor DNA sequence by recombinase mediated cassette exchange (RMCE), and the vector backbone sequence is simultaneously excluded. Of note: The Bxb-GT/GA dual landing pad platform is also available on the NSG background as Stock No. 036151, on the C57BL/6J background as Stock No. 036152, and on the albino B6 background as Stock No. 036153.
036363	C57BL/6J-Gt(ROSA)26Sor^{em25(KRT18-ACE2)Mvw}/MvwJ	B6.RMCE[K18-HuACE2]	B6.RMCE[K18-HuACE2] mice express human ACE2, the receptor used by severe acute respiratory syndrome coronavirus (SARS-CoV) to gain cellular entry. The human keratin 18 promoter directs expression to epithelial cells, including airway epithelia where infections typically begin. Because K18-HuACE2 mice are susceptible to SARS-CoV-2 and SARS-CoV viruses, they may be useful for studying antiviral therapies to COVID-19 and SARS. JAX is dedicated to supporting the scientific community in its response to the COVID-19 pandemic. View our portfolio of available models for SARS-CoV-2 research.
036511	129S(Cg)-Tgfbr1^tm1.1Hcd/J	Tgfbr1	Tgfbr1^M318R mice carry a missense knock-in mutation in the mouse Tgfbr1 (transforming growth factor, beta receptor I) gene. Heterozygous mice recapitulate classic and severe features of Loeys-Dietz syndrome (LDS), including aortic root aneurysms, skeletal malformations, and immune dysregulation.
036596	FVB.B6N-Gnb1^em2Frk/DgoldJ	Gnb1	Gnb1^D76G knockin mice express the D76G (aspartic acid to glycine) amino acid substitution in the Gnb1 (guanine nucleotide binding protein (G protein), beta 1) locus. The mutation results in homozygous perinatal or embryonic lethality. The mutation is associated with neurodevelopmental disease and lymphocytic abnormalities.
036776	C57BL/6J-Ism1^em1Kajs/J	Ism1-floxed	Ism1^fl mutant mice possess loxP sites flanking exon 2-4 of the Ism1 (isthmin 1, angiogenesis inhibitor) gene and may be useful in generating conditional mutations to study glucose regulation, diabetes and fatty liver disease.
036801	STOCK Prkar1a^tm1.2Lsk/J	Prkar1a	Prkar1a^lox/lox floxed mice have loxP sites flanking exon 2 of the Prkar1a gene. This strain is useful for studying the role of Prkar1a in physiology and tumorigenesis in any tissue.
036906	STOCK Tmem178b^{tm1c(KOMP)Wtsi} Tmem178^tm1.1Sud/J	Tmem178ab cKO, Tmem178a;Tmem178b	Tmem178ab cKO mice carry conditional mutations in both the mouse Tmem178 (transmembrane protein 178; also called Tmem178a) and Tmem178b (transmembrane protein 178B) genes. Exon 4 of each gene is flanked by loxP sites in the Tmem178a^fl (also called Tmem178a cko) and Tmem178b^fl (also called Tmem178b cko) alleles. The Tmem178a^fl allele also expresses an IRES-mVenus reporter, detectable though GFP immunohistochemistry in the absence of Cre recombinase.
036930	C57BL/6J-Col3a1^em2Hcd/J	Col3a1	Col3a1^G938D mice carry a glycine to aspartic acid (G938D) substitution at the end of the triple helical collagenous domain of the mouse Col3a1 (collagen type III alpha 1 chain) gene. This mutation is analogous to one found in human patients. Heterozygotes recapitulate Vascular Ehlers-Danlos syndrome (vEDS) vascular phenotypes with sudden death due to aortic rupture. The reported median survival time is 45 days. Homozygotes are not viable. The Jackson Laboratory is unable to ship this strain as live mice due to its severe phenotype. Please contact Customer Service for availability of frozen material.
036931	C57BL/6J-Col3a1^em1Hcd/J	Col3a1	Col3a1^G209S mice carry a glycine to serine (G209S) substitution at the beginning of the triple helical collagenous domain of the mouse Col3a1 (collagen type III alpha 1 chain) gene. This mutation is analogous to one found in human patients. Heterozygotes recapitulate Vascular Ehlers-Danlos syndrome (vEDS) vascular phenotypes with sudden death due to aortic rupture. The reported median survival time is 400 days. Homozygotes are not viable. The Jackson Laboratory is unable to ship this strain as live mice due to its severe phenotype. Please contact Customer Service for availability of frozen material.
037015	C57BL/6-U2af1^tm1.1Mjwa/J	U2af1	Exon 2 of the mouse U2af1 (U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1) gene is flanked by loxP sites in these U2af1^fl mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in studies of RNA splicing.
037016	C57BL/6-Cx3cr1^em1Mbur/J	Cx3cr1	Cx3cr1^D2 knock-in/knock-out mice express Dendra2 green/red photoswitchable monomeric fluorescent protein in myeloid cells including microglia and monocytes. Exposure of Dendra2-expressing cells to 405 nm laser light irreversibly switches green fluorescence to red, enabling labeling and tracking of cells.
037045	B6.Cg-Tg(Cdkn2a/luc/RFP/TK)1Cmps/J	p16-3MR	The p16-3MR BAC transgenic mouse model enables the visualization and elimination of senescent cells in living animals. The mouse p16^INK4a (Cdkn2a, cyclin dependent kinase inhibitor 2A) promoter drives expression of 3MR (trimodality reporter) fusion protein, which contains functional domains of a synthetic Renilla luciferase (LUC), monomeric red fluorescent protein (mRFP), and ganciclovir-sensitive truncated herpes simplex virus 1 (HSV-1) thymidine kinase (HSV-TK).
037182	NOD/ShiLtJ-Ptpn22^em2Shrm/J	NOD Ptpn22 +13NT (KO)	Ptpn22 knockout mice have a 13 nucleotide insertion (indel mutation) in exon 14 of the Ptpn22 (protein tyrosine phosphatase, non-receptor type 22 (lymphoid)) gene. On the autoimmune type 1 diabetes (T1D) susceptible NOD/LtShiJ background, the mutation enhances onset and penetrance of T1D.
037220	C57BL/6-Xpr1^tm1.1Frsv/J	Xpr1	Xpr1^lox conditional mutant mice possess loxP sites flanking exon 2 of the Xpr1 (xenotropic and polytropic retrovirus receptor 1) gene and may be useful in generating conditional mutations to study inorganic phosphate (Pi) regulation and bone and kidney disorders.
037247	B6.129S4-Ccn1^tm4Lfl/J	Ccn1	Ccn1^D125A/D125A knock-in mice have a neo cassette replacing Ccn1 gene with Ccn1^D125A cDNA that encodes a single amino acid substitution (Aspartate -125 to Alanine). This point mutation disrupts the α_v β₃ /α_v β₅ binding sites for CCN1. These mice may be useful for studying cell proliferation, endothelial adhesion, angiogenesis, apoptosis, and extracellular matrix formation. The donating investigator has made several Ccn1 mouse lines available: Ccn1^D125A (Stock No. 037247), Ccn1^DM (Stock No. 037248) and Ccn1^flox (Stock No. 037249).
037248	B6.129S4-Ccn1^tm2Lfl/J	Ccn1	Ccn1^DM/DM knock-in mice have a neo cassette replacing the Ccn1 gene with cDNA encoding Ccn1^DM, an α6β1 binding-defective CCN1. These mice may be useful for studying cell proliferation, endothelial adhesion, angiogenesis, apoptosis, and extracellular matrix formation. The donating investigator has made several Ccn1 mouse lines available: Ccn1^D125A (Stock No. 037247), Ccn1^DM (Stock No. 037248) and Ccn1^flox (Stock No. 037249).
037249	B6.129S4(FVB)-Ccn1^tm3.1Lfl/J	Ccn1	Ccn1^fl/fl mice possess loxP sites flanking exons 1-2 of the Ccn1 gene. After cre-mediated recombination, these mice may be useful for studying cell proliferation, endothelial adhesion, angiogenesis, apoptosis, and extracellular matrix formation. The donating investigator has made several Ccn1 mouse lines available: Ccn1^D125A (Stock No. 037247), Ccn1^DM (Stock No. 037248) and Ccn1^flox (Stock No. 037249).
037288	STOCK Tg(tetO-DMPK)A2352Coop Tg(Myl1-rtTA2SM2)1Lach/J	TREDT960I (TRE)	TREDT960I (TRE) double transgenic mice express a human genomic segment containing exons 11-15 of the DMPK gene with 960 interrupted CTG repeats (CUG960) under direction of the tetO (tet-responsive element) promoter. They also express the reverse tetracycline-controlled transactivator (rtTA) protein in skeletal muscle using the rat myosin light chain (Myl1) promoter. Together these two transgenes are useful when studying potential molecular mechanisms underlying skeletal muscle loss associated with Myotonic dystrophy type 1 (DM1).
037318	C57BL/6-H3c6^em1Sjes/J	H3.1-iCOUNT	H3.1-iCOUNT (inducible cell division counter) knock-in mice carry a loxP-flanked mCherry reporter followed by an EGFP reporter inserted upstream of the H3c6 (H3 clustered histone 6, also called H3.1) stop codon. Mice may be used to label cell division events in vivo.
036876	B6.Cg-Avpr1b^{tm2.1(cre)Wsy}/J	V1brCre	Avpr1b^Cre knock-in/knock-out mice have the endogenous arginine vasopressin receptor 1B promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Avpr1b-expressing cells/tissues (including the caudate-putamen, olfactory bulb, and pyramidal neurons in the CA2 region of the hippocampus), and may be useful in studying memory, aggression, and regulation of the hypothalamic-pituitary-adrenal (HPA) axis.
037012	B6.129P2(SJL)-Creld2^tm1.1Emass/J	Creld2	Creld2^eGFP/eGFP knock-in/knock-out mice have an enhanced green fluorescent protein (EGFP) sequence replacing the entire coding region of the Creld2 gene. These mice may be useful as a reporter for the maintenance of cell homeostasis and the resolution of ER stress.
036592	C57BL/6J-Fcer1g^em1Gfng/J	Fcer1g loxP	Fcer1g floxed mice have loxP sites flanking exons 2-3 of the Fc receptor, IgE, high affinity I, gamma polypeptide gene, which encodes the transmembrane domain. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Fcer1g floxed mice may be useful in studying microglial expression and function.
036825	B6.Cg-Agtr2^em1(cre)Adk/J	AT2R-Cre	AT2R-Cre knock-in mice have the endogenous Agtr2 promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Agtr2-expressing cells/tissues (including neurons GABAergic neurons in the nucleus of the solitary tract), and may be useful in studying hypertension.
036819	C57BL/6J-Tg(Slc10a2-TFRC/OVAL)1Pmall/J	OVA-BIL	OVA-BIL mice aberrantly express a membrane form of ovalbumin from the rat apical sodium-dependent bile acid transporter promoter (encoded by Slc10a2, solute carrier family 10, member 2) on biliary epithelium. Adoptive transfer of OVA-specific T cells results in liver inflammation in this model of immune-mediated hepatobiliary injury.
036820	C57BL/6J-Tg(Alb-TFRC/OVAL)1Pmall/J	OVA-HEP	OVA-HEP transgenic mice express chicken ovalbumin on the surface of hepatocytes. Adoptive transfer of naive ovalbumin-specific T cells into the mice leads to liver-specific inflammation in a dose dependent manner. Persistent inflammation develops after repeated transfer of antigen specific T cells. These mice have been useful in studies of autoimmune hepatitis.
037095	B6.FVB(Cg)-Tg(TPO-cre)1Shk/J	TPO-Cre	TPO-cre transgenic mice express Cre recombinase under the control of the human TPO promoter. They may be useful when studying thyrocytes and the generation of thyroid hormones.
036935	B6.FVB(Cg)-Tp(X)1Soff^{Tg(Myh11-icre/ERT2)1Soff}/ZjngJ	X-linked Myh11-CreER	This line of SMMHC-CreERT2 mice have a BAC transgene inserted in the X chromosome. These mice may be useful as a novel inducible Cre line that allows sufficient Myh11-driven Cre expression in smooth muscle cells (SMCs).
036382	C57BL/6J-Ms4a3^em2(cre)Fgnx/J	Ms4a3	Ms4a3^Cre knock-in mice express Cre recombinase under direction of the Ms4a3 promoter in granulocyte-monocyte progenitor cells (GMPs).
037028	B6.129-Calcr^{tm1.1(cre)Mgmj}/J	Calcr-Cre	Calcr^Cre mice have the endogenous calcitonin receptor (Calcr) promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Calcr-expressing cells/tissues (including neurons of the nucleus of the solitary tract, hypothalamus, and lateral reticular nucleus) and may be useful for studying feeding behavior, obesity, and metabolism.
036751	B6;SJL-Gfral^{em2(cre/ERT2)Rsy}/J	Gfral-CreERT	Gfral^CreERT mice have the endogenous GDNF family receptor alpha like (Gfral) promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Gfral-expressing cells/tissues (including neurons of the area postrema and nucleus of the solitary tract) and may be useful for studying feeding behavior, obesity, and metabolism.
036750	B6;SJL-Gfral^em1(cre)Rsy/J	Gfral-cre	Gfral^Cre mice have the endogenous GDNF family receptor alpha like (Gfral) promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Gfral-expressing cells/tissues (including neurons of the area postrema and nucleus of the solitary tract) and may be useful for studying feeding behavior, obesity, and metabolism.
036749	B6.129-Cckbr^{tm1.1(cre)Mgmj}/J	Cckbr-cre	Cckbr^cre knock-in mice have the endogenous cholecystokinin B receptor promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Cckbr-expressing cells/tissues (including neurons of the ventromedial nucleus of the hypothalamus), and may be useful in studying feeding behavior, obesity and diabetes.
036748	B6;SJL-Prlh^em2Mgmj/J	Prlh	Prlh^Flox mice have loxP sites flanking exon 3 of the prolactin releasing hormone (Prlh) gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These mice may be useful for studying feeding behavior, obesity, and metabolism.
036747	B6;SJL-Prlh^em1(cre)Mgmj/J	Prlh-cre	Prlh^Cre mice have the endogenous prolactin releasing hormone (Prlh) promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Prlh-expressing cells/tissues (including neurons of the nucleus of the solitary tract, dorsomedial hypothalamus, and lateral reticular nucleus) and may be useful for studying feeding behavior, obesity, and metabolism.
037144	B6.Cg-Usp16^tm2.1Hbwg/J	Usp16<2lox>	Usp16^2lox/2lox mice have loxP sites flanking exons 5-6 of the Usp16 gene. This mutant mouse strain may be useful in studies of physiological processes involving cascade cell lineage commitment, for example, hematopoiesis and hematopoietic stem cell function.
037104	B6(Cg)-Pigr^tm1.1Srmr/J	Pigr Fl	Pigr^fl/fl mice possess loxP sites flanking exons 5-10 of the Pigr gene. These mice may be useful for studying innate immunity and for modeling microbial dynamics in the human gut microbial equilibrium.
036853	B6.129S1-Rs1^tm1Web/J	Rs1h<->	Rs1h^- mice carry a targeted knock-out of the X-linked mouse Rs1 (retinoschisis (X-linked, juvenile) 1 (human)) gene in which portions of exons 3 and 4 are disrupted with an in-frame lacZ/neomycin cassette.
036854	B6.129S1-Timp3^tm1Hest/J	Timp3<->	Timp3^- mice carry a targeted knock-out of the mouse Timp3 (tissue inhibitor of metalloproteinase 3) gene that involves the disruption of exon 3 with a neomycin cassette. This strain has been useful in studies of Sorsby fundus dystrophy (SFD), a rare, late-onset macular dystrophy.
036855	B6.129S1-Timp3^tm1Web/J	Timp3	Timp3^S156C mice carry a serine to cysteine substitution in amino acid 156 (exon 5) of the mouse Timp3 (tissue inhibitor of metalloproteinase 3) gene. This strain has been useful in studies of Sorsby fundus dystrophy (SFD), a rare, late-onset macular dystrophy.
037067	FVB.129P2(B6)-Ctsa^tm1Adz/J	PPCA<->	PPCA^- mice carry a targeted knock-out allele of the mouse Ctsa (cathepsin A) gene and serve as a model of galactosialidosis, which is characterized by primary deficiency of cathepsin A and secondary severe deficiency of neuraminidase 1 (NEU1) and partial deficiency (15-20%) of beta-galactosidase (β-GAL).
037254	B6.129S6(Cg)-Gria1^tm8.1Rlh/J	SEP-GluA1 KI	SEP-GluA1 KI mice have a pH-sensitive super ecliptic pHluorin (SEP) variant of green fluorescent protein (GFP) fused to the extracellular N-terminus of the Gria1 by insertion into exon 1, resulting in the expression of a SEP-GluA1 fusion protein. These mice may be useful as a tool to monitor widespread synaptic strength and plasticity via fluorescence imaging in excitatory synapses throughout the entire brain.
037018	B6(SJL)-Gt(ROSA)26Sor^{tm1.1(CAG-iRFP/mScarlet-I/mTq2/mVenus)Rva}/J	Rosa26	These PRimary colours In the MEmbrane (PRIME) mice have a CAG promoter followed by three pairs of heterospecific lox sites (loxP, lox2272 and loxN), and the PRIME construct, all targeted into the Gt(ROSA)26Sor locus (Rosa^PRIME). PRIME contains four fluorescent proteins and functions as a Cre recombinase-inducible reporter of either a nuclear near-infrared fluorescent protein (3xNLS-iRFP670) or one of three membrane-bound fluorescent proteins from a single genomic locus.
037219	B6(Cg)-Slc6a1^tm1.1Ntrch/J	Gat1	Gat1^fl/fl floxed mice have loxP sites flanking exons 2-4 of the Slc6a1 gene. These mice may be useful when studying molecular mechanisms of GABA inhibitory neurotransmission.
033367	NOD.Cg-Flt3^em2Mvw Prkdc^scid Il2rg^tm1Wjl Tg(FLT3LG)7Sz/SzJ	NSG Flt3KO hFLT3LG Tg	This compound mutant strain was developed by combining a transgene expressing human FLT3LG (fms related receptor tyrosine kinase 3 ligand) and a knock-out of its receptor Flt3 (Flt3 interacting zinc finger protein 1) on the immunodeficient NSG background (NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ, Stock No. 005557). This humanized NSG Flt3KO hFLT3LG Tg strain when engrafted with human HSC is expected to show improved development of DC, pDC, monocytes, NK cells and mucosal immune system.
036936	B6.129(Cg)-Atp1a3^tm1.1Mika/Mmjax	Atp1a3 , Matoub , Matb+/-	Atp1a3^E815K knock-in mice carry a E815K amino acid substitution of the ATPase, Na+/K+ transporting, alpha 3 polypeptide or Matb. Heterozygous mice exhibit early onset spontaneous hemiplegia or seizures. The E815K mutation is lethal in homozygotes. These mice may be useful in studying alternating hemiplegia of childhood (AHC).
036999	B6.Cg-Col1a1^{tm1(tetO-cas9)Jnxu}*/J	dCas9-KRAB	dCas9-KRAB KI mice have a tetracycline-inducible promoter (TRE or tetO) driving expression of the dCas9-KRAB fusion protein - a human codon-optimized, nuclease-deficient, catalytically dead Cas9 protein (dCas9) fused to a Krüppel associated box domain (KRAB). When bred with another mouse expressing tetracycline-controlled transactivator protein (tTA) or reverse tetracycline-controlled transactivator protein (rtTA), dCas9-KRAB KI expression in the resulting double mutant offspring can be regulated with tetracycline or its analog doxycycline. Following doxycycline-administration and introduction of a single guide RNA (sgRNA), dCas9-KRAB binds to the target DNA sequence/locus, and that locus is subsequently silenced via heterochromatin formation and/or DNA methylation induced by the KRAB domain. These mice allow doxycycline-inducible, RNA-guided transcriptional repression (CRISPRi) of target genes in a wide range of cellular processes.
036925	B6.129(Cg)-Slc25a13^tm1Lct/TsahMmjax	Ctrn<->	Ctrn^-/- knockout mice have exon 10 replaced by a neomycin cassette in the Slc25a13 (solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 or Ctrn) gene. Homozygous null mice exhibit hypoglycemia, decreased insulin levels and increased liver triglycerides, as well as defects in ureogenesis and gluconeogenesis. This strain maybe of interest in studies of human citrin deficiency.
037053	B6.129-Gp1ba^tm1Ware/J	GP Ibα	GP Ibα^null mice have a neo cassette replacing the entire coding region of the Gp1ba gene, abolishing endogenous gene expression. These mice may be useful for studying blood disorders such as hypertension, cardiovascular disease, vascular inflammation, platelet dysfunction, coagulation defects, and Bernard-Soulier syndrome.
037054	B6.129(Cg)-Gp6^tm1Ware/J	GP VI	GP VI^null mice have a stop codon and a neo cassette inserted into exon 1 of the Gp6 gene, just 3' to the start codon, abolishing endogenous gene expression. These mice may be useful for studying blood disorders such as hypertension, cardiovascular disease, vascular inflammation, platelet dysfunction, coagulation defects, and Bernard-Soulier syndrome.
036662	B6.Cg-Tg(Lrat-cre)1Rshw/Mmjax	LratCre	LratCre transgenic mice express a cre recombinase directed by mouse Lrat (lecithin-retinol acyltransferase [phosphatidylcholine-retinol-O-acyltransferase]) promoter elements. Cre recombinase activity is observed in hepatic stellate cells in the liver as well as in Lrat-expressing cells of other organs. This strain may be useful for in vivo lineage tracing and functional analysis of hepatic stellate cells in liver fibrosis. Please note: LratCre females, but not males, must be used for breeding; breeding through the male may permanently alter cre activity. LratCre males may be used for experiments.
037055	STOCK Arf1^{tm1c(EUCOMM)Wtsi}/HousJ	Arf1	Exons 2-5 of the mouse Arf1 gene are flanked by loxP sites in these Arf1^fl mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in studies of lipid metabolism, cancer, and neurodegeneration.
035354	ManA/NachJ		The wild-derived M.m. domesticus pre-incipient inbred line ManA/NachJ may be used in crosses with common inbred strains to create multi-parent mouse mapping populations and for use as a source of natural phenotypic variation.
036927	STOCK Gpd2^tm1Tka Slc25a13^tm1Lct/TsahMmjax	Ctrn/mGPD	Ctrn/mGPD double knockout mice carry null alleles of both the Gpd2 (glycerol phosphate dehydrogenase 2, mitochondrial or mGPDH) and Slc25a13 (solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 or Ctrn) genes. Ctrn/mGPD mice develop citrullinemia, hyperammonemia, hypoglycemia and fatty liver and maybe used as a mouse model of human citrin deficiency.
035424	NOD.Cg-Prkdc^scid Il2rg^tm1Wjl Ace2^em1Lutzy/J	NSG Ace2	NSG Ace2^H353K knockin mice express an H353K (histidine to lysine) amino acid substitution in the Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) locus on the immunodeficient NSG background (NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ, Stock No. 005557). Ace2 is the receptor used for cellular entry by several coronaviruses, including severe acute respiratory syndrome coronavirus-1 (SARS-CoV) and -2 (SARS-CoV-2). This strain may be useful for the study of 2019 novel coronavirus (SARS-CoV-2) pathogenesis as well as cardiovascular disease. JAX is dedicated to supporting the scientific community in its response to the COVID-19 pandemic. View our portfolio of available models for SARS-CoV-2 research.
036603	(CByB6F1/J x C3D2F1/J)/J	HET3	HET3 (also called UM-HET3) mice are an established genetic diversity model for aging intervention studies, currently used by the NIA's Intervention Testing Program (ITP). HET3 mice are a genetically heterogeneous stock, produced by breeding CByB6F1/J and C3D2F1/J hybrids together. We are currently accepting pre-order for 10-26 week old HET3 mice, with distribution expected to begin November, 2022. We will make older animals available on a rolling basis following the timeline below: 26-52 weeks - May, 2023 52-78 weeks - November, 2023 78-90 weeks - February, 2024 90+ weeks - May, 2024

First Look Strains

Featured "First Look" Strains:

B6.RosaBxb-GT/GA

HET3

NSG Flt3KO hFLT3LG Tg

dCas9-KRAB

H3.1-iCOUNT

PlexinD1-2ACreER