First Look Strains

Stock Number	Name	Common Name	Description
038448	C57BL/6N-Tg(CAG-UFObow1.0)1Jnchn/J	UFObow	These UFObow mice have a CAG promoter followed by three pairs of heterospecific lox sites (loxN, lox2272 and loxP) separating four fluorescent proteins. It functions as a Cre recombinase-inducible reporter of either a secreted luciferase (secNluc) or one of three blue-excitable fluorescent proteins.
038164	B6.Cg-Gt(ROSA)26Sor^tm1Hjf/J	ROSA-tdRFP	ROSA26-tdRFP knock-in mice allow cre-inducible expression of a robust tandem dimer RFP (tdRFP) fluorescent reporter from the ubiquitously expressed Gt(ROSA)26Sor locus. This strain may be useful as a tool that is compatible with GFP- or YFP-expressing mice for in vivo lineage tracing and fate-mapping studies.
035831	C57BL/6-Crbn^tm2.1Ble/J	Crbn	Crbn^V380E/I391V mice carry both V380E and I391V changes in the mouse Crbn (cereblon) gene, providing an in vivo model for studying the effects of a newer thalidomide analogues and are suitable for use in applications related to the study of haematological malignancy, thalidomide analogue treatment, and treatment-induced cytopenias and teratogenicity.
038436	C57BL/6J-Crybb1^em1(icre)Cln/J	Crybb1-iCre	Crybb1-iCre knock-in/knock-out mice have an iCre recombinase gene inserted into exon 1 of the crystallin, beta B1 (Crybb1) locus, abolishing endogenous Crybb1 expression. When these mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequences in the Crybb1-expressing cells of the offspring. These mice may be useful for tracking microglia and border-associated macrophages (BAMS) during embryonic development.
036600	STOCK Ts(17¹⁶)66Yah/J	Ts66Yah	Ts66Yah mice are trisomic for about two-thirds of the genes orthologous to human chromosome 21, but lack the non-homologous 6.2Mb 17¹⁶ minichromosomal segment. These mice may be used for studying Down Syndrome.
035456	C57BL/6J-Abcb1a^em1Sbkv/SndrdJ	Abcb1a	CRISPR/Cas9 generated Abcb1a^ametrine mice express the ametrine fluorescent reporter sequence directed from the endogenous ATP-binding cassette, sub-family B (MDR/TAP), member 1A (Abcb1a) promoter. They are useful for visualizing MDR1 expressing cells, and for studying T cell-mediated immunity and inflammation, as well as regulation of oxidative stress.
038163	B6.129P2(Cg)-Kmt2e^tm1.1Hjf/J	Mll5-flox	Mll5-flox mice possess loxP sites flanking exons 3-4 (encoding the PHD domain) of the lysine (K)-specific methyltransferase 2E (Kmt2e, also known as Mll5) gene. These floxed mice are useful for tissue specific deletion of Kmt2e when studying Mll5 (Kmt2e) regulation of hematopoietic stem/progenitor cells.
038301	B6;SJL-Tg(ACTA1-rtTA)6Mcrth/J	HSA-rtTA	HSA-rtTA mice are a Tet-On tool that allows doxycycline-inducible expression of the reverse tetracycline-controlled transactivator (rtTA) protein in skeletal muscle using the human skeletal muscle α-actin (ACTA1) promoter.
038162	B6.Cg-Gata3^tm1.1Hjf/J	GATIR	GATIR knock-in mice carry a Venus yellow fluorescent reporter inserted into the Gata3 (GATA binding protein 3) locus. The insertion does not affect GATA3 expression and mice homozygous for the mutation are viable and fertile. This strain may be useful as a reporter for Gata3 expression in the T cell lineage, subsets of innate lymphoid cells (ILCs), a subset of thymus-derived NK cells, and in long-term hematopoietic stem cells.
038594	B6.129-H3f3a^tm1Hjf/J	H3.3A-K27M-FLAG	H3.3A-K28M conditional knock-in mice carry a K27M (see note) amino acid substitution, a 3XFLAG tag, and Venus reporter preceded by loxP-flanked wildtype H3f3a cDNA and an frt-flanked neo cassette in the H3f3a (H3.3 histone A) gene. This strain may be useful for research in cancers associated with the H3.3 variant.
037717	B6;D2-Tg(tetO-GCaMP8s)1Genie/J	TetO‐jGCaMP8s	TetO-jGCaMP8s transgenic mice express jGCaMP8s (an improved fast rise, moderate decay green fluorescent-based GECI with improved sensitivity and faster kinetics) controlled by a tetracycline‐responsive promoter element (TRE; tetO). When crossed with a transgenic mouse expressing tetracycline‐controlled transactivator protein (tTA), the jGCaMP8s transgene is activated and expression can be regulated with doxycycline.
037818	B6.Cg-Col1a1^{tm1(tetO-cas9)Ldow}*/Mmjax	Inducible Base Editor (IBE)	iBE knockin mice express a cytosine base editor (C:G to T:A) under the control of a tetO promoter. This strain provides temporal and regulatable in vivo cytosine base editing to create cancer-associated single nucleotide variants (SNVs).
037892	C57BL/6J-Tg(Thy1-APPDutch)#Jckr/J	APPDutch	APPDutch mice contain the Dutch E693Q mutation under direction of the Thy1 promoter and may be useful for studying the vascular amyloid aspect of Alzheimer's disease.
038643	C57BL/6J-Del(12Ighg3-Ighg2b)1Mzeng/J	IgG KO	IgG knock-out mice have an 80 kbp deletion that removes the IgG isotypes (Ighg1, Ighg2a, Ighg2b, and Ighg3). Homozygous mice develop an altered gut microbiome that promotes differentiation of IL17A-producing δγ T cells. This strain may be useful for research involving enteric pathogens and the gut microbiome.
038496	C57BL/6J-Gata3^em1Aben/J	Gata3	Gata3^Citrine knock-in mice carry a citrine fluorescent reporter inserted into the Gata3 (GATA binding protein 3) locus, while retaining endogenous Gata3 expression. This strain may be useful as a reporter for Gata3 expression in the T cell lineage and subsets of innate lymphoid cells (ILCs).
038498	C57BL/6J-Tcf7^em1Aben/J	Tcf7	Tcf7^mCherry knock-in mice carry an mCherry/3xFLAG reporter inserted into the Tcf7 (transcription factor 7, T cell specific) locus, while retaining endogenous Tcf7 expression. This strain may be useful as a reporter for Tcf7 expression in the T cell lineage and lymphoid tissue inducer (LTi) populations.
037459	STOCK Tg(Lmx1a-EGFP/cre)3Kjmi/J	Lmx1a-Cre	Lmx1a-Cre transgenic mice express a Cre recombinase/EGFP fusion under the control of the mouse Lmx1a (LIM homeobox transcription factor 1 alpha) promoter elements. Please note: the transgene inserted on the X chromosome. Cre recombinase activity is observed specifically in the roof plate (RF) and a subset of rhombic lip (RL) progenitors. This strain may be useful in fate mapping and manipulating gene expression in multiple Lmx1a populations.
037676	C57BL/6-Slc17a7^tm1.1Thna/J	Slc17a7 , VGLUT1	Slc17a7^flox mice possess loxP sites flanking exons 4-7 of the solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 (Slc17a7) gene. These mice may be useful for studying the role of Slc17a7 in learning and memory disorders, Alzheimer's disease, Parkinson's disease and other central nervous system diseases.
038190	B6.Cg-Gt(ROSA)26Sor^{tm1(CAG-Bcl2)Zhu}/J	Rosa26	These Rosa26^LSL-Bcl2 express a Cre-inducible Bcl2 gene and are useful when testing cancer models and when studying cell death during T-cell development.
038290	C57BL/6-Ntsr1^tm1.1Kff/BouvJ	NTSR1-Venus	NTSR1-Venus reporter mice have the neurotensin receptor 1 gene driving expression of a Venus yellow fluorescent protein. These mice may be useful as a means for visualizing receptor neuroanatomy and real-time receptor trafficking in live neurons.
038302	C57BL/6-Ackr3^tm1.1Kff/BouvJ	Ackr3-Venus	ACKR3-Venus/Venus reporter mice have the atypical chemokine receptor 3 gene driving expression of a Venus yellow fluorescent protein. These mice may be useful as a means for visualizing receptor neuroanatomy and real-time receptor trafficking in live neurons.
038300	B6.Cg-Tg(Dct-rtTA2S*M2)B8Mrln Tg(tetO-HIST1H2BJ/GFP)47Efu/J	iDct-GFP , Dct-rtTA/TRE-H2B-GFP	iDct-GFP mice target tetracycline/doxycycline-inducible green fluorescent protein (GFP) expression to melanocytes during all embryonic, neonatal, and adult developmental stages. This enables the sorting, tracking, and study of melanocytes, their associated diseases, and the development of melanoma when crossing with strains carrying melanomagenesis alleles.
038306	129S4/SvJae-Gt(ROSA)26Sor^tm7Sor/J	ROSA26	ROSA26^SAE translocation sensor mice conditionally express fluorescent ERK1/2 pathway and nuclear reporters from a single Gt(ROSA)26Sor transcript, enabling live-cell in vivo (whole embryo or animal) and ex vivo (cell line) studies of intracellular signaling in response to external stimuli.
038307	129S4/SvJae-Gt(ROSA)26Sor^tm8Sor/J	ROSA26	ROSA26^SAT translocation sensor mice conditionally express fluorescent ERK1/2 pathway, ATK pathway, and nuclear reporters from a single Gt(ROSA)26Sor transcript, enabling live-cell in vivo (whole embryo or animal) and ex vivo (cell line) studies of intracellular signaling in response to external stimuli.
038390	B6.Cg-Tg(KRT14-cre/ERT2)1Ipc/AkinJ	K14-Cre-ER	K14-Cre-ER^T2 mice express a tamoxifen-inducible Cre recombinase/ER^T2 fusion under the control of the human keratin K14 (KRT14) promoter/enhancer. Cre recombinase activity is observed in the basal layer of stratified squamous epithelia. This strain may be useful tool in studies of the epidermis.
038428	B6.129S4(Cg)-Tsc1^tm1Djk/MhnyJ	Tsc1	These Tsc1^c floxed mice possess loxP sites flanking exons 17 and 18 of the Tsc1 gene. This mutant strain may be useful in tissue-specific studies including tuberous sclerosis or other hamartoma syndromes, regulation of the actin cytoskeleton and motility, cellular and organismal glucose homeostasis, cell growth responses, apoptosis regulation, and regulation of cell size. Specifically on this congenic C57BL/6J background, mice are useful for creating a mouse model of chronic epilepsy.
038492	C57BL/6-Bmp10^{tm1(icre/ERT2)Fwin}/J	Bmp10-CreER	Bmp10-CreER^T2are knock-in mice with an inducible icre/ERT2 fusion gene inserted into the bone morphogenetic protein 10 (Bmp10) gene. BMP10 is expressed in the hepatic stellate cells (HSCs) of the liver. These mice can be used as research tool to study liver fibrosis.
038523	C57BL/6-Il1rl2^tm1.1Llsm/J	IL-36R	IL-36R^fl mice possess loxP sites flanking exon 3 of the Il1rl2 (interleukin 1 receptor-like 2 or IL-36R) gene. These floxed mice are useful for tissue specific deletion of IL-36R when studying inflammation and allergic diseases.
038286	STOCK Pcbp1^em8Salr/J	Pcbp1	Pcbp1^Flox mice possess loxP sites flanking the entire coding region of the poly(rC) binding protein 1 (Pcbp1) gene. These mice may be useful for studying the role of Pcbp1 in transcription and translational processes, cell proliferation and differentiation, as well as multiple cancers.
037699	C57BL/6J-Piezo1^em1Macki/J	PIEZO1-HA-knock-in	PIEZO1-HA-knock-in mice express a hemagglutinin-tagged form of PIEZO1 (piezo-type mechanosensitive ion channel component 1) that is useful for detecting the protein on cell surfaces.
038287	B6.Cg-Pcbp2^tm1.1Salr/J	Pcbp2	Pcbp2^Flox mice possess loxP sites flanking the promoter region and exons 1-2 of the poly(rC) binding protein 2 (Pcbp2) gene. These mice may be useful for studying the regulatory role of Pcbp2 in transcription and translational processes, cell proliferation and differentiation, as well as the oncogenic effects of Pcbp2 in multiple cancers.
038628	STOCK Pdgfra^{tm2.1(flpo)Leol} Gt(ROSA)26Sor^{tm65.2(CAG-tdTomato)Hze}/LeolJ	Pdgfra;fSf-Tomato	Pdgfra^Flp;fSf-Tomato mice have a floxed cassette containing both a cDNA encoding the Pdgfra gene and a flpo sequence replacing exons 2-4 of the endogenous Pdgfra gene. Mice also contain a conditional tdTomato fluorescent FLP reporter allele, Ai65F or fSf-Tomato. Cre recombination leads to the knock-out of Pdgfra expression and Flp/FRT-mediate intersectional lineage tracing of cre-expressing cells and their progeny.
038641	C57BL/6J-Rps12^em1Nbakr/J	RpS12	Exons 2 and 3 of the mouse ribosomal protein S12 (Rps12) gene are flanked by loxP sites in these Rps12^flox mice. Cre recombinase-mediated excision of the floxed region creates a knock-out allele useful in studies of Diamond-Blackfan Anemia (DBA) and ribosomal protein (Rp) function.
033000	129S4/SvJaeSorJ		This substrain of 129, from the steel group of 129 substrains (129S), is a common source of embryonic stem cell lines used in development of targeted mutations. The 129S4/SvJaeSor inbred strain, separated from the 129S4/SvJae parental subline in 1987, has been used to develop multiple embryonic stem cell lines including: AK7, AK7.1, and AK18.1.
036954	B6.Cg-Xpa^tm1Hvs Ercc8^em1(IMPC)H/Mmjax		Mice carrying knock-out alleles of Xpa (xeroderma pigmentosum, complementation group A) and Ercc8 (excision repaiross-complementing rodent repair deficiency, complementation group 8, also known as Csa) are combined to generate a mouse model of Cockayne syndrome, a multisystem disorder characterized by segmental progeria, growth failure, lipodystrophy, neurologic abnormalities, and severe photosensitivity.
038031	STOCK Del(11Hnf1b-Znhit3)11Moro/Mmjax	17q12Del	17q12Del mice have a 1.2 Mb deletion on syntenic mouse chromosome 11qC. 17q12 deletion syndrome is associated with neurodevelopmental disorders and renal cysts and diabetes syndrome (RCAD). The 17q12Del mouse phenocopies several features of the human disorder including, craniofacial and brain malformations in deletion mice, along with renal and diabetes phenotypes.
038460	B6129S-Syngap1^em1Rlh/Mmjax	Syngap1	Syngap1^L813RfsX22 mice have a frameshift mutation resulting in a premature stop codon in the Syngap1 [synaptic Ras GTPase activating protein 1 homolog (rat)] gene. Heterozygous mice display impaired synaptic plasticity, hyperactivity, and impaired working memory. This strain may be useful in studies of SRID (SYNGAP1-related intellectual disability). Of note, mice with another patient-derived Syngap1 mutation (c.3583-9G>A) is distributed as B6;129-Syngap1^em2Rlh/Mmjax, MMRRC No. 071392).
038461	B6129S-Syngap1^em2Rlh/Mmjax	Syngap1	Syngap1^c.3583-9G>A mice have a single base substitution resulting in a cryptic splice acceptor site and premature stop codon in the Syngap1 [synaptic Ras GTPase activating protein 1 homolog (rat)] gene. Heterozygous mice display impaired synaptic plasticity, hyperactivity, and impaired working memory. This strain may be useful in studies of SRID (SYNGAP1-related intellectual disability). Of note, mice with another patient-derived Syngap1 mutation (L813RfsX22) is distributed as B6;129-Syngap1^em1Rlh/Mmjax, MMRRC No. 071391).
036755	C57BL/6J-Slc6a1^em1Lutzy/Mmjax	B6J.LSL_Slc6a1	Slc6a1^em1Lutzy is a CRISPR/cas9 generated mutant of the Slc6a1 (solute carrier family 6 (neurotransmitter transporter, GABA), member 1) gene carrying a loxP-flanked STOP (LSL) in intron 6. The LSL prevents expression of Slc6a1, creating a reversible null allele. These mice may be useful in studies of molecular mechanisms of GABA inhibitory neurotransmission.
034602	C57BL/6J-Kcnn3^em1Lutzy/Mmjax	Kcnn3cKI	Kcnn3^V556F conditional knock-in/knock-out mice carry a lox-stop-lox (LSL) inserted upstream of the clinical V556F gain of function mutation in the Kcnn3 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) gene. The insertion of the LSL cassette is believed to result in a null allele. These mice may be useful in studying Zimmermann–Laband Syndrome (VLS). Mice expressing the V556F mutation are available as B6J(CBA)-Kcnn3^em1.1Lutzy/Mmjax (MMRRC Stock No. 071601).
034605	B6J(CBA)-Kcnn3^em1.1Lutzy/Mmjax	Kcnn3	Kcnn3^V556F knock-in mice express the clinical V556F gain of function mutation in the Kcnn3 (potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) gene. These mice may be useful in studying Zimmermann–Laband Syndrome (VLS). Mice with conditional expression of the V556F mutation are available as C57BL/6J-Kcnn3^em1Lutzy/Mmjax (MMRRC Stock No. 071600).
017961	STOCK Dscam^tm1Pfu/RwbJ	Dscam	Dscam^F mice possess loxP sites flanking the transmembrane encoding exon of the DS cell adhesion molecule (Dscam) gene. These floxed mice are useful for tissue specific deletion of Dscam when studying cell body spacing, developmental cell death and retinal development.
035178	STOCK Rara^tm1.1Sud/J	HA-RARalpha KI	HA-RARalpha KI knock-in mice express hemagglutinin-tagged mouse RARA (retinoic acid receptor, alpha) protein. Cre recombinase-mediated excision of floxed exons 4 and 5 results in the production of hemagglutinin-tagged RARA protein lacking the DNA binding domain.
035697	B6.Cg-Saa3^em1Litt Del(7Saa1-Saa2)1Itl/J	SAA	SAA^TKO mice carry a triple knock-out of mouse genes Saa1, Saa2, and Saa3, all of which are on Chromosome 7. This strain has been useful in studies of pathogenic Th17 cell involvement in inflammatory disease.
036257	STOCK Prcp^tm1.1Sdno/J	Prcp	Prcp^fl/fl mice have loxP sites flanking exon 4 of the Prcp gene. These mice are useful for studying the role of PRCP in the regulation of metabolism, hypertension, food intake and mood disorders.
036770	B6;SJL-Tg(Gm5127-cre/ERT2)1Mhsi/J	Gm5127(BAC)CreERT2	Gm5127(BAC)CreER^T2 transgenic mice express a tamoxifen inducible Cre recombinase/ERT2 fusion under the control of the mouse Gm5127 promoter elements. Cre recombinase activity is observed specifically in venous endothelial cells. This strain may be useful in studies of angiogenesis, and specifically, in fate mapping of venous endothelial cells in the brain and retinal and dermal vascular in postnatal and adult mice stages.
037204	B6;129-Omp^tm1Feins/RmncJ	OMP-H2B::mCherry	OMP-H2B::Cherry knock-in/knock-out mice may be useful for visualization of mature olfactory sensory neurons.
037667	C57BL/6J-Kcnc3^em1Jt/J	Kcnc3, Clueless	Kcnc3^G434V mice carry a CRISPR/Cas9-generated missense mutation in the mouse Kcnc3 (potassium voltage gated channel, Shaw-related subfamily, member 3) gene. The mutation decreases the activity of hippocampal neurons and causes defects in learning and memory in a fear-conditioning task.
037825	B6.129-P2ry6^tm1Jabo/J	P2ry6	P2ry6^fl/fl floxed mice have loxP sites flanking exon 3 of the P2ry6 gene. These mice may be useful when studying inflammatory responses.
037852	B6(Cg)-Nr1d1^tm1.1Laz/J	Rev-erbα	Rev-erbα^fl mice have loxP sites flanking exons 3-5 of the Nr1d1 gene. These mice may be useful when studying the circadian clock and its effects on metabolism.
037893	C57BL/6-Tg(Prnp-ITM2B*)7Jckr/J	ADanPP	ADanPP mice contain the Danish 10-nucleotide insertion (TTTAATTTGT) mutation in the human Itm2b gene under direction of the Prnp promoter and may be useful for studying amyloid deposition associated with Familial Danish dementia (FDD) synaptic dysfunction.
037963	CBA.Cg-Sst^{tm2.1(cre)Zjh}/AhsnJ	Sst-IRES-Cre	Sst-IRES-Cre knock-in mice express Cre recombinase in somatostatin-expressing neurons. These mice may be useful in studying dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells. While Sst-IRES-Cre was designed as a 3' knock-in allele, additional characterization indicates it has significantly diminished endogenous Sst expression - see details below. As such, researchers should consider using heterozygous Sst-IRES-Cre mice and wildtype littermate controls in all their studies. Of note, the same Sst-IRES-Cre knock-in allele is also available on a C57BL/6J genetic background as Stock No. 028864, a C57BL/6N genetic background as Stock No. 018973, and a STOCK background as Stock No. 013044.
037964	CBA.Cg-Chr 10^C57BL/6 Vip^tm1(cre)Zjh/AhsnJ	Vip-IRES-cre	Vip-IRES-Cre mice have Cre recombinase expression directed to Vip-expressing cells by the endogenous promoter/enhancer elements of the vasoactive intestinal polypeptide locus. Cre activity is detected in the neocortex, hippocampus, olfactory bulb, suprachiasmatic nuclei, and other discrete midbrain and brainstem regions. These mice may be useful to study neural GABAergic circuits throughout the mammalian brain. While Vip-IRES-Cre was designed to retain endogenous Vip expression, a 2019 publication indicates this allele has reduced Vip expression - see details below. As such, researchers may use homozygous mice for routine colony maintenance, but should consider using heterozygous Vip-IRES-Cre mice and wildtype littermate controls in all their studies. Of note, the same Vip-IRES-Cre knock-in allele is also available on a C57BL/6J genetic background as Stock No. 031628 and a STOCK background as Stock No. 010908.
038008	C.Cg-Plpp6^tm1Bdl/J	Plpp6<->	Plpp6 knock-out mice have the coding region of the Plpp6 (phospholipid phosphatase 6) gene replaced by a neomycin cassette. Homozygous null mice have reduced levels of cholesterol and a decreased response to induced allergic lung inflammation. This strain may be useful for studies involving cholesterol regulation, dendritic cell macropinocytosis, and allergen-induced lung inflammation.
038129	B6.Cg-Ascl3^{tm2.1(EGFP/icre/ERT2)Ovi}/J	Ascl3	Ascl3^P2A-GCE knock-in mice express an eGFP/iCreERT2 fusion protein in achaete-scute family bHLH transcription factor 3 (Ascl3)-expressing cells while retaining endogenous Ascl3 activity. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre recombinase activity is detected in the Ascl3-expressing cells of the offspring. Of note, the donating investigator has indicated that eGFP expression is not detectable either by direct fluorescence or immunohistochemistry.
038171	C57BL/6-Tg(Myh6-TFRC/OVA)#Ahlm/J	CMy-mOva	CMy-mOva mice express an V5- and His6-tagged cardiac myocyte restricted membrane-bound ovalbumin under the control of the Myh6 promoter. Hemizygous mice are tolerant to ovalbumin. This strain may be useful for research involving viral infections and cardiomyopathy.
038238	FVB/NJ-mt^C57BL/6J/DrweJ	FC	FC (FVB/NJ-mt^{MNX(C57BL/6J)}) is a conplastic strain in which the FVB/NJ strain carries the mitochondrial genome from C57BL/6J. This strain can be used for studies of complex diseases that have quantitative trait loci (QTL) identified in mitochondrial DNA. Of note: FB (FVB/NJ-mt^MNX(BALB/cJ)) is distributed as FVB/NJ-mt^BALB/cJ/DrweJ, Stock No. 038429. This strain carries the mitochondrial genome from BALB/cJ on the FVB/NJ host.
038245	C57BL/6-Tbr1^em1Boro/J	Tbr1-A136Pfs	Tbr1-A136fs knock-in mice carry a CRISPR/Cas9-generated frameshift mutation in the T-box brain transcription factor 1 (Tbr1) locus, which corresponds to the clinical mutation A136Pfs*80. These mice may be useful for studying neurodevelopmental disorders such as autism spectrum disorder (ASD).
038288	B6;SJL-Runx1^em1Salr/J	Runx1-ΔE6	Runx1-ΔE6 mice express a CRISPR-generated exon 6 splice variant of the runt related transcription factor 1 (Runx1) gene, which results in production of a mutant protein that lacks exon 6 encoded amino acids. These mice may be useful for studying the role of Runx1 in hematopoietic cell development and disorders, such as leukemias.
038296	B6.129S1(SJL)-Fezf2^tm1.1Nses/J	Fezf2	Fezf2^flox/flox mutant mice possess loxP sites flanking exon 2 of the Fez family zinc finger 2 gene. This strain may be useful for studying corticospinal motor neuron projections and immune tolerance.
038297	STOCK Rnd3^em1Nses/J	Rnd3	Rnd3^fl/fl mice carry a CRISPR/Cas9 generated mutation that results in loxP sites flanking exon 3 of the Rho family GTPase 3. This strain may be useful for studying corticospinal motor neuron projections and axon guidance.
038336	B6(CBA)-Pcdhg^em3Rwb/JaweJ	Pcdhg	Pcdhg^C3KO mice carry a CRISPR/Cas9-generated mutation in the Pcdhgc3 gene within the protocadherin gamma cluster (Pcdhg) on chromosome 18, making this strain useful when studying studying neuronal structure and function of hypothalamic neuronal circuitry.
038346	B6.129-Ptk6^tm1Aty/J	Ptk6<->	Ptk6^-/- mice have a neomycin resistance (neo) cassette replacing the transcription start site and the first exon of the PTK6 protein tyrosine kinase 6 (Ptk6) gene, abolishing endogenous gene expression. These mice may be useful for studying the regulation of growth and differentiation in normal epithelial cells as well as tumor cells.
038350	C57BL/6J-Txnip^em1Ngwu/J	NTX	NTX mice express a CRISPR-generated N-terminal double HA-tagged protein under direction of the endogenous thioredoxin interacting protein (Txnip) promoter. These mice may be useful for evaluating TXNIP localization patterns and function in glucose homeostasis, adipogenesis and energy metabolism.
038371	D2.Cg-Tg(DMD)#Spc Dmd^mdx*/J	hDMD(del45) mdxD2	The hDMD(del45) mdxD2 strain harbors both a mutant human DMD (dystrophin, muscular dystrophy) transgene, del45, and mouse Dmd knock-out allele. These mice may be useful for studying Duchenne and Becker muscular dystrophies. Our preclinical efficacy testing services offer scientific expertise and an array of target-based and phenotype-based outcome measures, both in vivo and at endpoint, for flexible study designs and assay development in mouse models of Muscular Dystrophy. See our full service platform.
038374	C57BL/6-Nnt^em1Asuh/J	6N<ΔNnt8-12>	6N^ΔNnt8-12 knock-out (KO) mice contain a CRISPR/Cas9 generated deletion of exons8-12 of the nicotinamide nucleotide transhydrogenase (Nnt) gene on a C57BL/6NJ genetic background. This strain may be useful for studying the role of Nnt in reduction/oxidation-dependent processes and mitochondrial dysfunction.
038375	C57BL/6J-Gzma^em1Asuh/J	Gzma	Gzma^S211A knock-in mice contain a CRISPR/Cas9 generated insertion of the S211A point mutation in granzyme A (Gzma) gene, resulting in a loss of GZMA enzymatic function. This strain may be useful for studying cell-mediated cytotoxicity.
038377	C57BL/6J-Ace2^em1Asuh/J	mACE2<->	mACE2^- knock-out (KO) mice carry a CRISPR/Cas9-generated deletion of the entire angiotensin converting enzyme 2 (Ace2) gene. In humans, ACE2 is the receptor used for cellular entry by several coronaviruses, including severe acute respiratory syndrome coronavirus-1 (SARS-CoV) and -2 (SARS-CoV-2). This strain may be useful as a mouse null control for the study of 2019 novel coronavirus (SARS-CoV-2) pathogenesis. JAX is dedicated to supporting the scientific community in its response to the COVID-19 pandemic. View our portfolio of available models for SARS-CoV-2 research.
038378	C57BL/6J-Serpinb2^em1Asuh/J	SerpinB2	SerpinB2^R380A knock-in (KI) mice contain a CRISPR/Cas9 generated insertion of the R380A (arginine>alanine) mutation in the serine (or cysteine) peptidase inhibitor, clade B, member 2 (Serpinb2) gene, resulting in a loss of enzymatic function. This strain may be useful for studying the regulatory role of Serpinb2 in plasminogen activation, cell migration and immune response pathways.
038391	STOCK Bcl11a^tm1.2Leid/J	Ctip1 , Bcl11a	Bcl11a^L2 (or Ctip^fl) mice possess loxP sites flanking exons 3-4 of the Bcl11a (B cell CLL/lymphoma 11A [zinc finger protein], also known as Ctip1) gene. These floxed mice are useful for tissue specific deletion of Bcl11a when studying skin disorders.
038429	FVB/NJ-mt^BALB/cJ/DrweJ	FB	FB (FVB/NJ-mt^MNX(BALB/cJ)) is a conplastic strain in which the FVB/NJ strain carries the mitochondrial genome from BALB/cJ. This strain can be used for studies of complex diseases that have quantitative trait loci (QTL) identified in mitochondrial DNA. Of note: FC (FVB/NJ-mt^{MNX(C57BL/6J)}) is distributed as FVB/NJ-mt^C57BL/6/DrweJ, Stock No. 038238. This strain carries the mitochondrial genome from C57BL/6J on the FVB/NJ host.
038462	C57BL/6J-Atoh1^em2Zyliu/J	Atoh1*3xV5-P2A-tdTomato	Atoh1-3V5-P2A-Tdtomato* mice have a CRISPR/Cas9-generated 3xV5 epitope tag and P2A-tdTomato cassette inserted into the C terminus of the atonal bHLH transcription factor 1 (Atoh1) gene. These mice are useful for visualizing inner hair cells (IHCs) and outer hair cells (OHCs) of the organ of Corti (OC) and as a tool for sorting pure neonatal cochlear HCs.
038463	C57BL/6J-Ikzf2^em1Zyliu/J	Ikzf2*3xV5-P2A-tdTomato	Ikzf2-3V5-P2A-Tdtomato* mice have a CRISPR/Cas9-generated 3xV5 epitope tag and P2A-tdTomato cassette fused to the C terminus of the IKAROS family zinc finger 2 (Ikzf2) gene. These mice are useful for visualizing outer hair cells (OHCs) of the organ of Corti (OC).
038465	C57BL/6-Dock3^em1Msalx/J	Dock3	Dock3^fl/fl mice carry a CRISPR/Cas9 generated mutation that results in loxP sites flanking exons 8-9 of the dedicator of cyto-kinesis 3 (Dock3) gene. These mice may be useful when studying neurodegeneration and metabolic dysregulation in skeletal muscle.
038489	B6;129-Ces1d^tm2Reli/J	Ces1d	Ces1d^Flox mice possess loxP sites flanking exon 5 of the carboxylesterase 1D (Ces1d) gene. These mice may be useful for generating conditional mutants to study the role of Ces1d in lipid metabolism and drug metabolism.
038493	STOCK Nde1^tm1Caw/YfngJ	Nde1<->	Nde1^-/- mice have exon 2 of the nudE neurodevelopment protein 1 gene removed, abolishing expression. These mice may be useful for studying microtubule organization, mitosis, neuronal migration, and cerebral cortex size.
038497	C57BL/6J-Rorc^{em1(Thy1)Aben}/J	Rorc	Rorc^Thy1.1 knock-in mice have the thymus cell antigen 1, theta (Thy1.1) sequence inserted into the 3' UTR of the Rorc locus, while retaining endogenous Rorc expression. This strain may be useful as a reporter for studying Rorc expression in T cell and innate lymphoid cell lineages.
038550	C57BL/6J-Pacs1^em2Gath/J	PACS1 , Pacs1 , Pacs1-LSL-R201W	PACS1^R201W conditional knock-in mice carry an R201W amino acid substitution preceded by a lox-STOP-lox (LSL) cassette in the Pacs1 (phosphofurin acidic cluster sorting protein 1) gene. This strain may be useful for research in neurodevelopmental disorders such as PACS1 syndrome. Of note, the mutant R203W human PACS1 gene is distributed as C57BL/6J-Gt(ROSA)26Sor^{em2(CAG-PACS1)Gath}/J (Stock No. 038551). In addition, the the human PACS1 control is distributed as C57BL/6J-Gt(ROSA)26Sor^{em2(CAG-PACS1)Gath}/J (Stock No. 038552).
038551	C57BL/6J-Gt(ROSA)26Sor^{em1(CAG-PACS1R203W)Gath}*/J	R26 , ROSA26-LSL-PACS1-R203W , Gt(ROSA)26Sor	R26^P1R203W knock-in mice have conditional, widespread expression of the human PACS1 (phosphofurin acidic cluster sorting protein 1) gene with the human R203W variant associated with with developmental delay and intellectual disability (PACS1 syndrome). This strain may be useful for studies involving research in neurodevelopmental disorders such as PACS1 syndrome. Of note, the wild-type human PACS1 gene is distributed as C57BL/6J-Gt(ROSA)26Sor^{em2(CAG-PACS1)Gath}/J (Stock No. 038552). In addition, the orthologous mouse R201W mutation knocked in to the mouse Pacs1 locus is distributed as C57BL/6J-Pacs1^em2Gath/J (Stock No. 038550).
038552	C57BL/6J-Gt(ROSA)26Sor^{em2(CAG-PACS1)Gath}/J	R26 , ROSA2-LSL-PACS1-WT , Gt(ROSA)26Sor	R26^P1 knock-in mice have conditional, widespread expression of the human PACS1 (phosphofurin acidic cluster sorting protein 1) gene. This strain may be useful for studies involving research in neurodevelopmental disorders such as PACS1 syndrome. Of note, the mutant R203W human PACS1 gene is distributed as C57BL/6J-Gt(ROSA)26Sor^{em2(CAG-PACS1R203W)Gath}/J (Stock No. 038551). In addition, the orthologous mouse R201W mutation knocked in to the mouse Pacs1* locus is distributed as C57BL/6J-Pacs1^em2Gath/J (Stock No. 038550).
038570	B6.Cg-Flrt2^em1Jnk/J	FLRT2 , FLRT2	FLRT2^UF mice carry a point mutation that disrupts interactions between fibronectin leucine rich transmembrane protein 2 (FLRT2) and its ligands of the unc-5 netrin receptor family (UNC5A, UNC5B, UNC5C, and UNC5D). This strain has been useful in studies of selective synaptic partnering by neurons and FLRT2-UNC5 signaling.
038571	STOCK Ndufs2^tm1.1Job Tg(CAG-cre/Esr1*)5Amc/J	Inducible MCI-PARK	Inducible MCI-PARK mice, based on the ESR-NDUFS2 strain described by Fernández-Agüera, 2015 (PMID: 26437605), were generated through an intercross of mice carrying a floxed allele of mouse NADH:ubiquinone oxidoreductase core subunit S2 (Ndufs2; derived from Stock No. 036313) with animals that broadly express tamoxifen-inducible cre recombinase (Tg(CAG-cre/Esr1)5Amc; Stock No. 004682). Induction with tamoxifen creates a conditional knock-out of Ndufs2, useful in studies of Parkinson’s disease (PD). Distribution of this double mutant strain (Stock No. 038571) was supported by the Michael J. Fox Foundation for Parkinson's Research*.
038572	B6.Cg-Gt(ROSA)26Sor^{tm1.1(CAG-Mfsd2a)Chgu}/J	R26, Rosa26:LSL-Mfsd2a	R26^LSL-Mfsd2a mice enable conditional, Cre recombinase-dependent overexpression of mouse MFSD2 lysolipid transporter A, lysophospholipid (Mfsd2a) upon excision of a loxP-flanked Stop cassette. This strain has been useful in studies of neurovascular coupling.
038578	C57BL/6-Gpr182^em1Thln/J	GPR182	GPR182^mCherry knock-in/knock-out mice contain a CRISPR/Cas9-generated insertion of mCherry replacing the entire coding region of the Gpr182 gene. These mice may be useful for tracking expression of the atypical chemokine receptor (ACKR), GPR182, and for studying its role as a chemokine scavenger.
038581	B6(129)-Creb5^em1Alb/J	Creb5	Creb5^flox9/flox9 mice carry a CRISPR/Cas9 generated mutation that results in loxP sites flanking exon 9 of the cAMP responsive element binding protein 5 (Creb5) gene. These mice may be useful when studying synovial joint formation and the development of articular chondrocytes.
038582	STOCK Fbxo2^{tm1.1(cre/ERT2)Akg}/J	Fbxo2	Fbxo2^CreERT2 knock-in/knock-out mice express a CreER fusion protein driven by the F-box protein 2 (Fbxo2) endogenous promoter, while abolishing endogenous Fbxo2 expression. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Fbxo2-expressing cells of the offspring. These mice may be useful when studying inner ear sensory epithelial cells.
038583	STOCK Gt(ROSA)26Sor^{em1(CAG-Atoh1/EGFP)Akg}/J	ROSA-A	ROSA-A knock-in mice have a CRISPR/Cas9 generated insertion of a floxed STOP cassette and Atoh1 sequence fused to an enhanced green fluorescent protein (eGFP) inserted into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in ATOH1/eGFP expression in Cre expressing tissues. These mice may be useful for the labeling and isolation of Atoh1-expressing neurons, auditory hair cells, skin cells and secretory cells in the gut.
038584	STOCK Gt(ROSA)26Sor^{em2(CAG-Gf1i,-Atoh1/EGFP)Akg}/J	ROSA-GA	ROSA-GA knock-in mice have a CRISPR/Cas9 generated insertion of a floxed STOP cassette, followed by an Gfi1 sequence and a Atoh1 sequence fused to an enhanced green fluorescent protein (eGFP), into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in co-expression of the transcription factors GFI1 and ATOH1/eGFP in cre-expressing tissues. These mice may be useful for evaluating overexpression of GFI1 and ATOH1 in neuronal and auditory hair cell development, differentiation and regeneration.
038585	STOCK Gt(ROSA)26Sor^{em3(CAG-Gf1i,-Atoh1/EGFP,-Pou4f3)Akg}/J	ROSA-GAP	ROSA-GAP knock-in mice have a CRISPR/Cas9 generated insertion of a floxed STOP cassette, followed by a Gfi1 sequence, an Atoh1 sequence fused to an enhanced green fluorescent protein (eGFP) and a Pou4f3 sequence, into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in co-expression of the transcription factors GFI1, ATOH1/eGFP and POU4F3 in cre-expressing tissues. These mice may be useful for evaluating overexpression of GFI1, ATOH1 and POU4F3 in neuronal and auditory hair cell development, differentiation and regeneration.
038586	STOCK Foxi3^em1Akg/J	Foxi3	Foxi3^GFP knock-in mice carry an mVenus fluorescent reporter inserted immediately downstream of the Foxi3 coding region, while retaining endogenous Foxi3 expression. This strain may be useful as a reporter for tracking Foxi3-expressing cells during embryogenesis; specifically, neuroepithelial cells, pharyngeal arches and pouches, as well as hair and tooth progenitor cells. The donating laboratory has also made a Foxi3^CreER knock-in/knock-out mouse line available as Stock No. 038587.
038587	STOCK Foxi3^{em2(cre/ERT2)Akg}/J	Foxi3	Foxi3^CreER knock-in/knock-out mice have a CreER fusion protein driven by the Foxi3 endogenous promoter, while abolishing endogenous Foxi3 expression. This strain may be useful for Cre-lox studies of Foxi3-expressing cells during embryogenesis; specifically, neuroepithelial cells, pharyngeal arches and pouches, as well as hair and tooth progenitor cells. Although eGFP is also present in this Foxi3^CreER allele, its low level of expression from the construct did not allow detection of the eGFP protein, either by native fluorescence or by immunostaining with GFP antibodies. The donating laboratory has also made a Foxi3 reporter line available that retains endogenous Foxi3 expression: Foxi3^GFP (Stock No. 038586).
038596	C57BL/6-Traf7^tm1.1Ifd/J	Traf7, Traf7-floxed	Exons 2-14 of the mouse TNF receptor-associated factor 7 (Traf7) gene are flanked by loxP sites in these Traf7^fl conditional mutant mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele, useful in studies of vascular development and integrity.
038627	STOCK Pdgfra^{tm1(flpo)Leol} Gt(ROSA)26Sor^{tm65.2(CAG-tdTomato)Hze}/LeolJ	Pdgfra;fSf-Tomato	Pdgfra^K.Flp;fSf-Tomato knock-in/knock-out mice have a floxed stop cassette and cDNA encoding a constitutively active Pdgfra gene (D842V; PDGFRα^K) with a T2A-flpo sequence replacing the PDGFRα^K stop codon. Mice also contain a conditional tdTomato fluorescent FLP reporter allele. Cre recombination leads to the activation of PDGFRA kinase activity and Flp/FRT-mediated lineage tracing in cre-expressing cells.
038629	STOCK Gt(ROSA)26Sor^{tm65.2(CAG-tdTomato)Hze} Pdgfrb^{tm1.1(flpo)Leol}/LeolJ	Pdgfrb;fSf-Tomato	Pdgfrb^Flp;fSf-Tomato mice have a floxed cassette containing both a cDNA encoding the Pdgfrb gene and a flpo sequence replacing exons 2-4 of the endogenous Pdgfrb gene. Mice also contain a conditional tdTomato fluorescent FLP reporter allele, Ai65F or fSf-Tomato. Cre recombination leads to the knock-out of Pdgfrb expression and Flp/FRT-mediated intersectional lineage tracing of cre-expressing cells and their progeny.

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First Look Strains

Featured "First Look" Platforms:

UFObow

NRG2 and NRG2-DKO

Crybb1-iCre

VGLUT1^flox

NSG Flt3KO hFLT3LG Tg

NSG-SGM3-IL15

First Look Strains

Featured "First Look" Platforms:

UFObow

NRG2 and NRG2-DKO

Crybb1-iCre

VGLUT1flox

NSG Flt3KO hFLT3LG Tg

NSG-SGM3-IL15

VGLUT1^flox