Webinar: CRISPR/Cas-Mediated Genome Engineering in Mice

The promises of precise, combinatorial, efficient methods for genomic engineering are exciting. The CRISPR/Cas technology applied to mouse genetic engineering could quickly advance scientific understanding of disease mechanisms by allowing researchers to ask complex questions and find answers much faster than with traditional gene targeting approaches. During this webinar, Dr. Haoyi Wang, one of the developers of this revolutionary technology will share how CRISPR/Cas has been used successfully in mice to generate endogenous knock-in alleles, conditional ("floxed") mutations, as well as multiple mutations in a single generation.

In this webinar, you will learn about the following topics:

• Key genetic components rendering NSG mice immunodeficient
• How CRISPR/Cas9 works to modify host genomes
• How this technology compares to similar technologies
• Ways in which CRISPR/Cas9 has been used to make targeted mutations and insertions
• Technical challenges and practical considerations

Presenter: Haoyi Wang, Ph.D., Adjunct Faculty, The Jackson Laboratory