Differences Among B6 Substrains & the Research Impact

1:00 PM ET, 5:00 PM GMT (Convert this time to your time zone)

The C57BL/6 inbred mouse (B6) is the most commonly used research strain. This strain is the most well characterized, the first to have its entire genome sequenced, and the genetic background strain of choice for most targeted mutations and transgenics. The universal acceptance and demand for B6 mice has necessitated their production from multiple sources, introducing genetic and phenotypic variability that has important consequences for accurately interpreting and repeating research results. In this webinar, we will discuss the following topics:

• A brief historical perspective on the development of B6 inbred mice and different substrains

• Recent publications highlighting significant physiological and behavioral differences among different B6 inbred mice

• The significance of control selection and experimental design

• Key tips for avoiding common B6 research mistakes

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