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CRISPR/Cas9 techniques are quickly growing in popularity for the generation of new mouse models for research. Many researchers struggle with understanding the complexities associated with the diverse alleles that can be generated, how to deal with mosaicism, and how to move from a single founder mouse to larger cohorts for phenotype characterization. In this webinar, we will discuss the following topics:
Understanding the molecular mechanisms that drive the array of possible mutations that can result from a single Cas9/sgRNA targeting strategy
A summary of various common targeting strategies to generate indel, knockout, and knockin mutations using CRISPR/Cas9
Selection of founder mice and breeding strategies for mitigating mosaicism in founder mice
Breeding strategies to establish a colony and generate cohorts for experimentation
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