This new symposium will bring together experts in mouse and human genetics with experts in the study of pluripotency to discuss the use of genetically diverse panels of murine and human pluripotent stem cell lines and analyses of genetic heterogeneity.
In-Person Capacity: 30 | Virtual Option Available
Registration is Open
May 23 - 25
2023
Pluripotent stem cells hold great promise for deciphering disease mechanisms and discovering new medicines, and for providing new cell therapies for intractable medical conditions. However, genetic diversity is often overlooked when developing in vitro cellular models even though it impacts maintenance of pluripotency, differentiation propensity, and response to developmental queues. Only through the study and intentional incorporation of genetically diverse panels of stem cells can we ensure that the benefits of this research are distributed equitably.
The goal of this multi-disciplinary conference is to bridge the gap between the fields of genetics and stem cell biology and to support the application of methods in systems genetics, functional genomics, and high content screening to diverse pluripotent stem cells at scale.
We encourage graduate students, postdoctoral fellows, and junior and senior investigators in genetics, genomics, stem cell biology and computational biology to attend.
The in-person course will consist of seminars, hands-on methodological and data analysis workshops and evening discussions to bring together interdisciplinary scientists, support early career scientists and trainees, and build productive collaborations. The virtual audience will have access to a live stream of didactic lectures.
The Jackson Laboratory (JAX) Courses and Conferences program is committed to:
(1) Fostering an educational and working environment that encourages and supports our mission and the promotion of free and open exchange of scientific ideas;
(2) Creating and maintaining a safe and respectful environment for all in-person and virtual participants in educational programs, including event directors and organizers, internal and invited speakers, attendees, and all staff; and
(3) Providing an environment free from discrimination and harassment, in accordance with federal, state and local law, at all of our courses, conferences, symposia and workshops delivered both on and off of the JAX campuses.
The Code and expectations outlined below are aligned with the JAX Code of Conduct and NIH Policy and are applicable to all intramural and extramural participants including faculty, trainees, students and staff.
By registering for and attending a JAX Courses and Conferences -facilitated meeting or event, either in person or virtually, participants agree to:
By participating in JAX Courses and Conferences programming attendees, either in person or virtually, agree to refrain from:
What to do in case of breaches or violations of these guidelines:
Program organizers and leadership can be approached informally about any apparent or actual breaches or violations. Breaches or violations should be reported to the specific program leader or to JAX Courses and Conferences organizers in person or by email:
Reports can be submitted by those who experience harassment or discrimination as well as by those who witness violations of the behavior laid out in this Code. The TDCC will act as needed to resolve the matter, up to and including immediate expulsion of the offending participant(s) from the meeting and exclusion from future events offered by JAX. Individuals at any NIH-supported conference who have questions, concerns or complaints related to harassment or discrimination can also file a report with the HHS Office for Civil Rights (OCR) or notify NIH. Seeking assistance from a program leader or organizer in no way prohibits filing complaints with HHS OCR.
3:00 PM |
Monday, May 22nd 3:00 pm Registration Participants may not enter Highseas prior to 3:00pm
5:00 pm Social Hour
6:00 pm Dinner
7:00 pm Course Welcome & Introductions Chris Baker, Ph.D., The Jackson Laboratory |
8:00 AM |
Tuesday, May 23rd 8:00 am Welcome & Announcements Chris Baker, Ph.D., The Jackson Laboratory
GENETIC IMPACT ONPLURIPOTENCY AND CELL IDENTITY
8:00 – 8:30 am No cell left behind: dynamic studies of gene regulation in humans Yoav Gilad, Ph.D., University of Chicago
8:30 – 9:00 am Talk Title TBD Steve Munger, Ph.D., The Jackson Laboratory
9:00 – 9:30 am Harnessing natural genetic variation to determine epigenomic mechanisms of cellular identity and function Chris Baker, Ph.D., The Jackson Laboratory
9:30 – 10:00 am From genotype to phenotype with single-cell resolution Oliver Stegle, Ph.D., European Molecular Biology Laboratory
10:00 – 10:30 am Moderated Panel Discussion Moderator: Ralda Nehme, Ph.D., The Broad Institute
PRECISION MODELING HUMAN VARIANTS IN STEM CELLS
10:45 – 11:15 am Unsupervised Machine Learning Identifies Chromatin Accessibility Regulatory Networks that Define Cell State Transitions in Pluripotency Kelly Frazer, Ph.D., University of California, San Diego
11:15 – 11:45 am An in vitro neurogenetics platform for precision disease modeling Martin Pera, Ph.D., The Jackson Laboratory
1:00 – 1:30 pm Precise, high-efficiency editing of stem cells to probe human biology and model disease Bill Skarnes, Ph.D., The Jackson Laboratory
1:30 – 2:00 pm A stem cell approach to human development, from reconstitution to deconstruction using CRISPR screens Danwei Huangfu, Ph.D., Sloan Kettering Institute
2:00 – 2:30pm Moderated Panel Discussion Chris Baker, Ph.D., The Jackson Laboratory
3:00 – 5:00 pm Workshop – Concepts in quantitative trait locus analysis Daniel Gatti, Ph.D., The Jackson Laboratory
7:00 - 8:30 pm Evening Session - Grantsmanship Workshop Iiro Taneli Helenius, M.Sc., PhD, The Jackson Laboratory Highseas, 3rd Floor |
8:00 AM |
Wednesday, May 24th
|
8:00 AM |
Thursday, May 25th
|
Senior Lecturer in Stem Cell Biology
Senior Group Leader, Research Scientist
Principal Investigator
Senior Group Leader
Director, Institute for Genomic Medicine, Professor of Pediatrics
Professor of Medicine
Professor
Professor and Director, Mount Sinai Institute for Systems Biomedicine
Associate Professor
Associate Director, Stem Cell Program
Professor
Associate Professor
Professor
Professor, Cellular Engineering
Assistant Professor
Associate Group Leader
Assistant Professor
Professor
Registration Fee: $900; Optional Shared Lodging Fee: $200
Registration Fee: $900; Optional Shared Lodging Fee: $200
Standard Registration Fee: $250; Scholarship Applicant Registration Fee: $50
On-Campus
Lodging accommodations at JAX’s Highseas Conference Center is available for an additional fee. Highseas, located approximately 1 mile from The Jackson Laboratory, is a spacious estate built in 1912, overlooking the entrance to Frenchman Bay and adjacent to beautiful Acadia National Park. Attendees are responsible for their own transportation to the Conference Center. We do provide shuttles to and from the main campus for the duration of the course. Highseas is handicap accessible (please indicate accessibility needs in registration). This lodging option cannot accommodate families. Lodging might be shared with other participants.
Off-Campus
Participants interested in securing off-campus lodging may refer to the Bar Harbor Chamber of Commerce website for a guide on hotels, motels, bed & breakfasts, and short-term rentals in the Bar Harbor area.
Meals will be provided by JAX’s campus dining services throughout the event. Participants staying off-campus may still partake in meals at Highseas. Please refer to the event schedule for more information.
Air
Bar Harbor is serviced by two airports:
Hancock County/Bar Harbor Airport (BHB) – 20 minutes away
Bangor International Airport (BGR) – 1hr 15 minutes away
Public transportation is not available from local airports. Please visit the Bar Harbor and Bangor airport services webpages for information on shuttles to and from Mount Desert Island. Rideshare options like Uber or Lyft are not commonly available.
Ground
Bar Harbor is approximately 5 hours by car from the greater Boston area. Rental cars are available from Hertz at either nearby airport. Additionally, there is a free Island Explorer bus system which can be used around the island and the national park.
Additional Area Information:
Bar Harbor Chamber of Commerce
Acadia National Park