Sep 09 Systems Immunology in Aging and Complex Diseases

Cofactors in immune aging and COVID-19

September 9 - 10, 2021

This 2-day live, virtual meeting will break down silos of specialization and will coalesce leading scientists from three disciplines (immunology, aging and computational biology) with shared interests in understanding aging at the systems level and in curing aging-related diseases. Topics that will be covered will include senescence, immune system aging, cognitive decline with aging, and clinical and genomic biomarkers of aging. In addition, there will be talks on recent advances in genomic technologies such as single cell profiling technologies and microbiome profiling. Participants will have access to recordings and meeting content for two weeks after the meeting ends.

Please contact the event organizer for more information

About

Aging is a complex and multi-dimensional phenotype that affects all tissues of all organisms. In humans, aging–related diseases, including cardiovascular diseases, cancer and type 2 diabetes, pose a huge health and economic burden, which will continue to increase as the aging population is expected to double by 2030. Disruption of immune cell functions and responses plays a significant role in the etiology of many aging-related diseases. Recent advances in genomic technologies (e.g., single cell transcriptomics and epigenomics) enable precise description of molecular and cellular changes associated with aging in human cells as well as in model organisms, including the mouse. However, uncovering the functional and clinical significance of these genomic and cellular changes is a significant computational challenge.

This 2-day virtual meeting integrates three disciplines (immunology, aging and computational biology) in order to understand aging at the systems level and to address curing of aging-related diseases. Highlighted topics include senescence, immune system aging, cognitive decline with aging, recent advances in genomic technologies, and clinical and genomic biomarkers of aging.

Give a talk during the event!
Attendees are encouraged to submit an abstract to be considered for a short talk.
Submit an abstract during registration until August 20, 2021.

Participants will have access to meeting content and recordings for two weeks after the meeting ends.

Research reported in this publication is supported by the National institutes of Health and National Institute of Aging under Award Number R13AG069519. The content is solely the responsibility of the authors and does not necessarily report the official views of the National Institutes of Health.

Schedule

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September09

September10

9:30 AM

Day 1

Thursday, September 9^th

9:30 am EDT
Opening Remarks
George Kuchel, M.D., FCP, AGSF UConn Center on Aging and University of Connecticut & Duygu Ucar, Ph.D., The Jackson Laboratory for Genomic Medicine

Session 1: Sex and genetics in immune responses/diseases
Session Moderator: Duygu Ucar, Ph.D., The Jackson Laboratory for Genomic Medicine

9:40 am EDT
Sex Differences in Immunity to SARS-CoV-2
Sabra Klein, Ph.D., Johns Hopkins University

10:20 am EDT
Lifelong Sex Differences in Neutrophil Phenotypes
Bérénice Benayoun, Ph.D., USC Leonard Davis

11:00 am EDT
Break

11:20 am EDT
Keynote Lecture: Genetic and Immunological Causes of Life-Threatening COVID-19
Jean-Laurent Casanova, M.D., Ph.D., The Rockefeller University

12:20 pm EDT
Lunch Break

Session 2: Epigenetics in immune responses and diseases
Session Moderator: Asa Thibodeau, Ph.D., Jackson Laboratory

1:00 pm EDT
High-Throughput Genomic Technologies for Human Immunology
Ansuman Satpathy, M.D. PhD., Stanford University

1:40 pm EDT
Interpreting Genetic Variants Through Chromatin Interaction Maps In Primary Human Immune Cells
Ferhat Ay, Ph.D., La Jolla Institute for Immunology

2:20 pm EDT
Short Talk 1
Single-Cell Epigenetic and Transcriptional Analyses of an Aging Immune System Reveal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging
Denis Mogilenko, Ph.D., Washington University in St. Louis

2:40 pm EDT
Break

Session 3: Metabolic dysfunctions

Session Moderator: Berenice Benayoun, Ph.D., USC Leonard Davis

3:00 pm EDT
Dysregulation of the Adipose-Resident Immune Compartment Drives Thermogenic Failure During Aging
Emily Goldberg, Ph.D., University of California, San Francisco

3:40 pm EDT
Immuno-Metabolic Dysregulation in Macrophages During Aging: Aging at the Cross Roads of Inflammation and Metabolism
Anthony Covarrubias, Ph.D., University of California, Los Angeles

4:20 pm EDT
The Microbiome Contributes to Unhealthy Aging
Dawn Bowdish, Ph.D., McMaster University

5:00 pm EDT
Mitochondrial-Encoded Immunity

Changhan David Lee, Ph.D., University of Southern California

5:40 pm EDT
Panel/Open Discussion with the Day’s Speakers

9:30 AM

Day 2

Friday, September 10^th

Session 4: Biomarkers of aging

Session Moderator: Duygu Ucar, Ph.D., The Jackson Laboratory for Genomic Medicine

9:30 am EDT
Human Immune Monitoring Coming of Age
Shai Shen Orr, Ph.D., Technion - Israel Institute of Technology

10:10 am EDT
Biomarkers for Geroscience-Guided Clinical Trials
Jamie Justice, Ph.D., Wake Forest School of Medicine

10:50 am EDT
Quantification of the Pace of Biological Aging From a Blood Test: the DunedinPoAm DNA Methylation Algorithm
Daniel Belsky, Ph.D., Columbia University

11:40 am EDT
Short Talk 2
Cellular and Plasma Proteomic Determinants of Healthy Aging Vs. Inflammation
Maxim Artyomov, Ph.D., Washington University School of Medicine

12:00 pm EDT
Lunch Break

Session 5: Infectious diseases

Session Moderator: Djamel Nehar-Belaid, Ph.D., The Jackson Laboratory

12:40 pm EDT
Developing Therapies to Improve Antiviral Immunity in Older Adults
Joan Mannick, M.D., Life Biosciences

1:20 pm EDT
Host Responses to SARS-CoV-2 Infection
Adolfo Garcia-Sastre, Ph.D., Icahn School of Medicine at Mount Sinai

2:00 pm EDT
Immunity
Patrick Wilson, Ph.D., Weill Cornell Medicine

2:40 pm EDT
Short Talk 3
Senescence-Induced Changes in CD4 T Cell Differentiation Can be Alleviated by Treatment With Senolytics
Laura Haynes, Ph.D., University of Connecticut, School of Medicine

3:00 pm EDT
Panel/Open Discussion with the Day’s Speakers

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