Systems Immunology in Aging and Complex Diseases - Virtual Event

Day 1

Thursday, September 9^th

9:30 am EDT
Opening Remarks
George Kuchel, M.D., FCP, AGSF UConn Center on Aging and University of Connecticut & Duygu Ucar, Ph.D., The Jackson Laboratory for Genomic Medicine 

Session 1: Sex and genetics in immune responses/diseases
Session Moderator: Duygu Ucar, Ph.D., The Jackson Laboratory for Genomic Medicine

9:40 am EDT
Sex Differences in Immunity to SARS-CoV-2
Sabra Klein, Ph.D., Johns Hopkins University

10:20 am EDT
Lifelong Sex Differences in Neutrophil Phenotypes
Bérénice Benayoun, Ph.D., USC Leonard Davis

11:00 am EDT
Break

11:20 am EDT
Keynote Lecture: Genetic and Immunological Causes of Life-Threatening COVID-19
Jean-Laurent Casanova, M.D., Ph.D., The Rockefeller University

12:20 pm EDT
Lunch Break

Session 2: Epigenetics in immune responses and diseases
Session Moderator: Asa Thibodeau, Ph.D., Jackson Laboratory

1:00 pm EDT
High-Throughput Genomic Technologies for Human Immunology
Ansuman Satpathy, M.D. PhD., Stanford University

1:40 pm EDT
Interpreting Genetic Variants Through Chromatin Interaction Maps In Primary Human Immune Cells
Ferhat Ay, Ph.D., La Jolla Institute for Immunology

2:20 pm EDT
Short Talk 1
Single-Cell Epigenetic and Transcriptional Analyses of an Aging Immune System Reveal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging
Denis Mogilenko, Ph.D., Washington University in St. Louis

2:40 pm EDT
Break

Session 3: Metabolic dysfunctions

Session Moderator: Berenice Benayoun, Ph.D., USC Leonard Davis

3:00 pm EDT
Dysregulation of the Adipose-Resident Immune Compartment Drives Thermogenic Failure During Aging
Emily Goldberg, Ph.D., University of California, San Francisco

3:40 pm EDT
Immuno-Metabolic Dysregulation in Macrophages During Aging: Aging at the Cross Roads of Inflammation and Metabolism
Anthony Covarrubias, Ph.D., University of California, Los Angeles

4:20 pm EDT
The Microbiome Contributes to Unhealthy Aging
Dawn Bowdish, Ph.D., McMaster University

5:00 pm EDT
Mitochondrial-Encoded Immunity

Changhan David Lee, Ph.D., University of Southern California

5:40 pm EDT
Panel/Open Discussion with the Day’s Speakers

Day 2

Friday, September 10^th

Session 4: Biomarkers of aging

Session Moderator: Duygu Ucar, Ph.D., The Jackson Laboratory for Genomic Medicine

9:30 am EDT
Human Immune Monitoring Coming of Age
Shai Shen Orr, Ph.D., Technion - Israel Institute of Technology

10:10 am EDT
Biomarkers for Geroscience-Guided Clinical Trials
Jamie Justice, Ph.D., Wake Forest School of Medicine

10:50 am EDT
Quantification of the Pace of Biological Aging From a Blood Test: the DunedinPoAm DNA Methylation Algorithm
Daniel Belsky, Ph.D., Columbia University

11:40 am EDT
Short Talk 2
Cellular and Plasma Proteomic Determinants of Healthy Aging Vs. Inflammation
Maxim Artyomov, Ph.D., Washington University School of Medicine

12:00 pm EDT
Lunch Break

Session 5: Infectious diseases

Session Moderator: Djamel Nehar-Belaid, Ph.D., The Jackson Laboratory

12:40 pm EDT
Developing Therapies to Improve Antiviral Immunity in Older Adults
Joan Mannick, M.D., Life Biosciences

1:20 pm EDT
Host Responses to SARS-CoV-2 Infection
Adolfo Garcia-Sastre, Ph.D., Icahn School of Medicine at Mount Sinai

2:00 pm EDT
Immunity
Patrick Wilson, Ph.D., Weill Cornell Medicine

2:40 pm EDT
Short Talk 3
Senescence-Induced Changes in CD4 T Cell Differentiation Can be Alleviated by Treatment With Senolytics
Laura Haynes, Ph.D., University of Connecticut, School of Medicine

3:00 pm EDT
Panel/Open Discussion with the Day’s Speakers