This two-day workshop introduces genetic mapping using qtl2, a R package for analyzing quantitative phenotypes and genetic data from complex crosses like the Diversity Outbred (DO). Genetic mapping with qtl2 allows researchers in fields as diverse as medicine, evolution, and agriculture to identify specific chromosomal regions that contribute to variation in phenotypes (quantitative trait loci or QTL). The goal is to identify the action, interaction, number, and precise location of these regions.
Participants will learn to
calculate genotype and allele probabilities
perform a genome scan and plot the results
evaluate statistical significance of results
find estimated effects of a QTL on a phenotype
account for relationships among individuals by using a kinship matrix