About
Aging is a complex and multi-dimensional phenotype that affects all tissues of all organisms. In humans, aging–related diseases, including cardiovascular diseases, cancer and type 2 diabetes, pose a huge health and economic burden, which will continue to increase as the aging population is expected to double by 2030. Disruption of immune cell functions and responses plays a significant role in the etiology of many aging-related diseases. Recent advances in genomic technologies (e.g., single cell transcriptomics and epigenomics) enable precise description of molecular and cellular changes associated with aging in human cells as well as in model organisms, including the mouse. However, uncovering the functional and clinical significance of these genomic and cellular changes is a significant computational challenge.
This 2-day meeting will bring together leading scientists from three disciplines (immunology, aging and computational biology) with shared interests in understanding aging at the systems level and in curing aging-related diseases. Topics that will be covered will include senescence, immune system aging, cognitive decline with aging, clinical and genomic biomarkers of aging. In addition, there will be talks on recent advances in genomic technologies such as single cell profiling technologies and microbiome profiling.
