Neurogenetic ToolsPast Event

Using Mouse Models to Study Human Neurodegenerative Disease - Details

Location: The Jackson Laboratory, Bar Harbor ME

This JAX course will focus on the use of the innovative tools and methods, specifically in the laboratory mouse, for answering questions of neuron and circuit function and disease mechanisms during neurodegeneration. This course will employ both didactic and hands-on instruction in both laboratory techniques and bioinformatics.

NEW FOR 2017: Webcasting. Those unable to join our Courses and Conferences now have the ability to attend via webcast.

Please contact the event organizer for more information

May 08 - 12

2017

About

This event has past. This is an archived page.

This five day workshop is focused on the use of the mouse in neuroscience studies, particularly neurodegenerative disease. It will survey current methods in the field with a strong emphasis on neurogenetic tools. Last year's faculty included leaders in the field such as Loren Looger, HHMI Janelia Research Campus, Samuel Wang, Princeton University, Nicolas Renier, Rockefeller University, and scientists from The Allen Institute. Workshops topics will include but are not limited to:

peripheral and central nervous system disease models
optogenetics
tissue clearing methods
CRE/LOX systems
single cell genomics
development of disease models using CRISPR/Cas9
optopatch system
bioinformatic databases and data analysis tools
using viral vectors for gene delivery and tracing
behavioral analysis
forward and systems genetics approaches to complex trait analysis

NEW FOR 2017: Webcasting. Those unable to join our Courses and Conferences now have the ability to attend via webcast. Enrollees will receive a Canvas login and password, which enables virtual live attendance for the majority of lecture sessions. Recordings will also be available within 48 hours and access will be permitted for six months following the conclusion of the course.

Schedule

Download full Schedule

May08

May09

May10

May11

May12

8:00 AM

Introduction to Neurodegenerative Disease and The Jackson Laboratory

8:00am
Introduction to JAX
Nadia Rosenthal, Ph.D., Scientific Director, The Jackson Laboratory

8:30am
Course overview and History of mouse models
Mike Sasner, Ph.D., Research Scientist, The Jackson Laboratory

9:30am
Model validity
Robert Burgess, Ph.D., Professor, The Jackson Laboratory

10:30am
Break

11:00am
PNS Disease Models
Gregory Cox, Ph.D., Professor, The Jackson Laboratory

12:00pm
Lunch

1:00pm
Transportation to Main Lab

1:15pm
Group A: Biomethods in the Mouse
Kristin Cough, Animal Use Trainer, The Jackson Laboratory

Group B: Single Cell Genomics Prep
Paul Robson, Ph.D., Director of Single Cell Biology, The Jackson Laboratory

2:30pm
Break

3:00pm
Group B: Biomethods in the Mouse
Kristin Cough, Animal Use Trainer, The Jackson Laboratory

Group A: Single Cell Genomics Prep
Paul Robson, Ph.D., Director of Single Cell Biology at The Jackson Laboratory

4:15pm
Transportation back to Highseas

4:30pm
Student Symposium and Social Hour

Highseas Conference Center

8:30 AM

Resources for Neuroscience

8:30am
Cre driver resources: tools and best practices
Mike Sasner, Ph.D., Research Scientist, The Jackson Laboratory

9:30am
Workshop: The CrePortal Resource at MGI: finding suitable mouse Cre recombinase lines and additional integrated data at MGI
Cynthia Smith, Research Scientist, The Jackson Laboratory
David Shaw, Database User Support Specialist, The Jackson Laboratory

10:30am
Break

11:00am
Complex Trait Genetics and Database Resources
Elissa Chesler, Ph.D., Professor, The Jackson Laboratory

12:00pm
Lunch

1:00pm
Workshop: Exploring cell types using the Allen Brain Atlas: navigating the multimedia data sets featuring transgenic lines
Terri Gilbert, Ph.D., Application Scientist, The Allen Institute

5:00pm
Generation of transgenic mice with tightly regulated expression for cell type-specific studies
Tanya Daigle, Ph.D., Scientist, The Allen Institute

Highseas Conference Center

8:30 AM

Genetic Tools for Neuron Function and Circuit Analysis

8:30am
GcAMP
Loren Looger, Ph.D., Group Leader, HHMI Janelia Research campus

9:30am
Optogenetics and Optopatch
Adam Cohen, Ph.D., Professor, Harvard University

10:30am
Transportation

11:00am
Option 1: DEMONSTRATION: Perfusion and Brain Dissection (striatum, cortex, hippocampus, hypothalamus, cerebellum, etc.)
Jim Miller, Necropsy Technologist, The Jackson Laboratory

Option 2: Electrophysiology Basics
Kristen O’Connell, Ph.D., Professor, The Jackson Laboratory

12:00pm
Lunch

1:00pm
Workshop: Tissue Clearing: CLARITY vs. iDISCO
Doug Richardson, Ph.D., Director of Imaging, Harvard Center for Biological Imaging

4:45pm
Workshop: Tissue Vision
Tim Ragan, Ph.D., CEO of TissueVision

The Jackson Laboratory

8:30 AM

Genetic Analysis

8:30am
Single cell genomics
Paul Robson, Ph.D., Director of Single Cell Biology, The Jackson Laboratory

9:30am
CRISPR
Bill Buaas, Ph.D., Associate Director of Genetic Engineering Technologies, The Jackson Laboratory

10:30am
Break

11:00am
Viral vectors
Ryuta Ishimura, Ph.D., Molecular and Viral Vector Scientist, The Jackson Laboratory

12:00pm
Lunch

1:00pm
Computational Genomics
Greg Carter, Ph.D., Professor, The Jackson Laboratory

2:00pm
WORKSHOP: Single cell genomics analysis
Paul Robson, Ph.D., Director of Single Cell Biology, The Jackson Laboratory

Highseas Conference Center

8:30 AM

Development of Genetic Disease Models

8:30am
Models with a purpose: AD variants
Gareth Howell, Ph.D., Professor, The Jackson Laboratory

9:15am
Creation of Clinically Relevant Models
Catherine Kaczorowski, Ph.D., Professor, The Jackson Laboratory

10:00am
AlzForum resources
Kelly Dakin, Ph.D., Scientific Content Manager, AlzForum

10:30am
Break

11:00am
The Science, Art, & Anecdotes of Behavioral Testing: Improving Reproducibility & Translation in Animal Models
Stacey Rizzo, Ph.D., Associate Director of Mouse Neurobehavioral Phenotyping, The Jackson Laboratory

12:00pm
Lunch

1:00pm
Pre-clinical Imaging
Paul Territo, Ph.D., Professor, Indiana University

2:00pm
Pre-clinical Pharmacology
Paul Territo, Ph.D., Professor, Indiana University
Stacey Rizzo, Ph.D., Associate Director of Mouse Neurobehavioral Phenotyping, The Jackson Laboratory

Highseas Conference Center

Participants and some faculty reside together at Highseas Conference Center, a Georgian style mansion built in 1912. Highseas is perched on the cliffs overlooking the entrance to Frenchman Bay and surrounded by beautiful Acadia National Park. This is casual, dormitory-style housing, consisting of shared bedrooms and bathrooms. Wireless internet access is provided throughout the building. Laundry facilities are available on site.

Please refer to the Bar Harbor Chamber of Commerce for lodging alternatives available for purchase. A few options are Blackwoods Campground, Quimby House Inn & Spa, Atlantic Oceanside Hotel or Bar Harbor Grand Hotel.

Air

Bar Harbor is served by two airports:

Hancock County/Bar Harbor Airport (BHB)
Bangor Airport (BGR)

Car

Bar Harbor is approximately 6 hours by car from the greater Boston area.

Rental cars are available from Hertz at BHB and BGR

Public Transportation

There is a free bus system available that runs throughout Bar Harbor - Island Explorer. The Jackson Laboratory is located between The Village Green and Sieur de Monts on the Sand Beach (Bus 3) Route.

Area information:

Event Contact

Kelly LaRue Brackett, Ph.D.

207-288-1442

Erin McDevitt, M.S.

People

Supporters

Howard Hughes Medical Institute

Neurogenetic ToolsPast Event

Using Mouse Models to Study Human Neurodegenerative Disease - Details

Location: The Jackson Laboratory, Bar Harbor ME

About

Schedule

Travel Information

Air

Car

Public Transportation

Area information:

Event Contact

Kelly LaRue Brackett, Ph.D.

207-288-1442

Erin McDevitt, M.S.

People

Kelly LaRue Brackett, Ph.D.

The Jackson Laboratory

Michael Sasner, Ph.D.

The Jackson Laboratory

Supporters

Funding for this course has been generously provided by