Dr. Bolcun-Filas researches meiosis, the biological process of egg and sperm formation. Her research aims to understand the molecular mechanisms controlling the development of healthy gametes and how misregulation of these mechanisms can lead to reproductive disorders. In particular, she is interested in meiotic “quality checkpoints” operating in germ cells, which ensure that the correct and intact genetic information is transmitted to the next generation. That same checkpoint is responsible for the high sensitivity of oocytes to cancer treatment. Chemo and radiation therapies can cause oocyte death and lead to premature ovarian failure and infertility.
Dr. Bolcun-Filas obtained her Msc from Jagiellonian University, Krakow, Poland, her PhD in Developmental Biology from the Georg-August-Universitat, Institut fur Humangenetik, Gottingen, Germany, completed a post-doctoral fellowship at MRC Human Genetics Unit, Edinburgh, UK., and was a post-doctoral associate and research scientist at Cornell University until she joined The Jackson Laboratory in 2015.