Our unique, patented Genetic Stability Program (GSP) effectively limits cumulative genetic drift, including that caused by copy number variation (CNV), by rebuilding our foundation stocks from cryopreserved, pedigreed embryos every five generations. The program was initiated in 2003 (Taft et al. 2006), and is covered in patents issued in 2010 (US patent 7,592,501) and 2012 (US patent 8,110,721).
Currently, the following inbred strains are managed using our GSP protocols:
Preventing cumulative genetic drift in these strains is particularly important because the strains have been either completely or partly sequenced: C57BL/6J was completely sequenced by the Mouse Genome Sequencing Consortium (Waterston et al. 2002); and 129S1/SvImJ, BALB/cByJ, C3H/HeJ, DBA/2J, FVB/NJ, NOD/ShiLtJ and nine other JAX Mice strains were sequenced by the National Institute of Environmental Health Sciences Resequencing Project (Frazer et al. 2007).
Regularly “refreshing” mutant colonies maintained on these backgrounds by periodically backcrossing to our GSP inbred strains ensures that the genetic backgrounds of these mutant colonies remain genetically similar to the parent inbred and to other mutant strains maintained similarly.