NSG™-SGM3
The triple transgenic NSG-SGM3 mice enable superior engraftment of myeloid and CD4+ T cell lineages and primary AML samples and are useful for immuno-oncology, immunology and infectious disease studies.
NSG™小鼠品系的免疫缺陷程度最高，
是癌症跨物种移植、干细胞生物学、
人源化小鼠、以及传染病研究的
首选小鼠模型。
| 品系名称及库存编号 |
NOD.Cg-Prkdcscid
|
NOD.Cg-Prkdcscid
Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ (013062) |
NOD.Cg-Rag1tm1Mom
|
|---|---|---|---|
| 品牌名或通用名 | NSG™（商标名），NOD scid gamma | NSGS，NOD scid gamma Il3- GM-SF (NSG-SGM3) |
NRG，NOD Rag gamma |
| 成熟 B 细胞 | 无 | 无 |
无 |
| 成熟 T 细胞 | 无 | 无 | 无 |
| 树突状细胞 | 有缺陷 | 有缺陷 | 有缺陷 |
| 巨吞噬细胞 | 有缺陷 | 有缺陷 | 有缺陷 |
| 自然杀伤细胞 | 无 | 无 | 无 |
| 细胞补体 | 无 | 无 | 无 |
| 细胞渗漏 | 极低 | 无 | 无 |
| 辐射耐受剂量 | 低 | 低 | 高 |
| 淋巴肿瘤发病率 | 低 | 低 | 低 |
| 品系优势 |
|
|
|
| 注意事项 |
|
|
|
| 参考文献 | Nicolini 等人 2004; Wunderlich 等人 2010; Billerbeck 等人 2015 |
| 名称及库存编号 |
NSG-HLA-A2.1 (009617)NSG-HLA-A2/HHD (014570) |
DR1 (012479)DR4 (017637) |
NSG B2m (010636)NSG-(KbDb)null (023848) |
|---|---|---|---|
| 商标名或俗名 | HLA I-A2 类转基因小鼠 | HLA II 类转基因小鼠 | MHC I 类 null NSG™ |
| 成熟 B 细胞 | 无 | 无 | 无 |
| 成熟 T 细胞 | 无 | 无 | 无 |
| 树突细胞 | 有缺陷 | 有缺陷 | 有缺陷 |
| 巨噬细胞 |
有缺陷 |
有缺陷 | 有缺陷 |
| 自然杀伤细胞 | 无 | 无 | 无 |
| 补体 | 无 | 无 | 无 |
| 渗漏 | 低 | 低 | 低 |
| 辐射耐受性 | 低 | 低 |
低 |
| 淋巴瘤发病率 | 低 | 低 | 低 |
| 优势 |
|
|
|
| 注意事项 |
|
|
|
| 参考文献 | Shultz 等人 2010 | Covassin 等人 2011 | Covassin 等人 2013 |
The triple transgenic NSG-SGM3 mice enable superior engraftment of myeloid and CD4+ T cell lineages and primary AML samples and are useful for immuno-oncology, immunology and infectious disease studies.
Our study-ready NSG™ mice are the most versatile immunodeficient strain. Start your research today with our readily-available models.
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