Cancer Treatment Profile™

Providing informative genomic profiling of tumors
for targeted therapy response.

jaxmoleculardx@jax.org | 1.860.837.2320

Gene List

358 Gene panel (SNPs and micro InDels):

A1CF, ABL1, ACVR1B, ADAR, ADARB1, AFF2, AGO1, AGO2, AGO3, AGO4, AICDA, AKT1, AKT2, AKT3, ALK, AMER1, APC, APOBEC1, APOBEC2, APOBEC3A, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, APOBEC4, AR, ARID1A, ARID1B, ARID2, ASH1L, ASXL1, ATM, ATN1, ATP10B, ATR, ATRX, AURKA, AURKB, AURKC, AXIN1, B2M, BAP1, BCL2, BCOR, BCR, BID, BRAF, BRCA1, BRCA2, BRIP1, BTK, CARD11, CARM1, CASP8, CBFB, CBL, CCND1, CCNE1, CCR2, CDC73, CDH1, CDK12, CDK4, CDK6, CDKN1B, CDKN2A, CDKN2C, CHEK2, CIC, CIRBP, COL18A1, CREBBP, CRLF2, CSF1R, CSMD3, CTCF, CTNNB1, CXCR4, CYLD, DALRD3, DAXX, DDIT4, DDR2, DICER1, DNMT1, DNMT3A, DNMT3B, DOT1L, DROSHA, DSPP, EGFR, EHMT2, EP300, EPHA10, EPHA3, EPHA5, EPHB6, ERBB2, ERBB3, ERBB4, ESR1, ETV6, EZH1, EZH2, FAM166A, FAT4, FBXO4, FBXW7, FER1L5, FES, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FOXA1, FUBP1, GATA1, GATA2, GATA3, GLI1, GLI2, GLI3, GNA11, GNAQ, GNAS, GPR32, GPRIN2, GRIN2A, GPS2, H3F3A, HAUS5, HCFC1R1, HES1, HEY1, HEY2, HGF, HIST1H1C, HIST1H2BC, HIST1H3B, HLA-A, HMCN1, HNF1A, HRAS, HSBP1, HSF1, HSF2, HSF4, HSP90AA1, ID1, ID2, ID3, IDH1, IDH2, IGF1R, IKZF1, INHBA, INO80C, ITPKB, JAK1, JAK2, JAK3, JMJD1C, JMJD6, KCNQ2, KDM1A, KDM1B, KDM2A, KDM2B, KDM3A, KDM3B, KDM4A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C, KDM6A, KDM6B, KDR, KEAP1, KIT, KLF4, KLHL6, KMT2C, KMT2D, KRAS, LATS1, LATS2, LLGL2, LMO1, LRFN4, LRP1B, LTK, LYSMD3, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK8, MAPK9, MDM2, MDM4, MED12, MED23, MEN1, MET, MLH1, AFDN (MLLT4), MPL, MSH2, MSH6, MST1, MTOR, MUC16, MUC17, MUC4, MUC5B, MYB, MYC, MYCL (MYCL1), MYCN, MYD88, MYT1L, NCOA3, NCOR1, NEK10, NF1, NF2, NFE2L2, NKAIN4, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NPM1, NRAS, NSD1, NTRK1, NTRK2, NTRK3, PAK3, PALB2, PAX5, PBRM1, PDGFA, PDGFB, PDGFRA, PDGFRB, PGR, PHF6, PIK3CA, PIK3R1, PIP4K2C, PIWIL1, PLK1, PMS1, PMS2, POLB, POLI, PPEF1, PPP2R1A, PQLC2, PRDM1, PRDM14, PRDM2, PRDM9, PRKAA1, PRKAA2, PRMT1, PRMT2, PRMT3, PRMT5, PRMT6, PRRX1, PTCH1, PTEN, PTK2B, PTPN11, PTPRD, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54B, RAD54L, RAD54L2, RAF1, RASA3, RASGRF2, RB1, RET, RNF43, ROR2, ROS1, RPGR, RUNX1, SAAL1, SCGB1C1, SETBP1, SETD2, SETD7, SF3B1, SKP2, SLC38A3, SMAD2, SMAD4, SMARCA4, SMARCB1, SMO, SMYD3, SOS1, SOX9, SPOP, SRC, SRSF2, STAG2, STK11, STK3, TARBP2, TBL1XR1, TBP, TBX3, TCF7L2, TEAD1, TEAD2, TEAD4, TET2, TGFBR2, TLE6, TMEM82, TNFAIP3, TP53, TP63, TP73, TRAF7, TSC1, TSHR, TTC5, TTN, U2AF1, UBC, USH2A, VHL, NSD2 (WHSC1), NSD3 (WHSC1L1), WNT7A, WT1, WWTR1, XRCC2, XRCC3, YAP1, YES1, ZFP36L1, ZMYND19

Genetic Drift

Clinical Knowledgebase

JAX-Clinical Knowledgebase (CKB) is a powerful tool for interpreting complex genomic profiles, and represents a valuable resource for clinicians and translational and clinical researchers around the world.

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gene_fusion

FusionSeq™

The FusionSeq™ assay is designed to detect fusions involving one or more of 53 genes known to be associated with various carcinomas, sarcomas and hematologic malignancies.  

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New CRISPR

ActionSeq™

ActionSeq™ is a targeted panel of 212 cancer related genes analyzed using next-generation sequencing. The panel assesses all identified functional variants for clinical relevance, based on associations in the biomedical literature with response or resistance to FDA-approved targeted therapies. 

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