Clinical Knowledgebase (CKB)

JAX-CKB is a powerful tool for interpreting complex genomic profiles, and represents a valuable resource for clinicians and translational and clinical researchers. JAX-CKB advances JAX’s mission to discover genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

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CKB

JAX-CKB can help increase clinician confidence in completeness and accuracy of the information related to the patient’s tumor genomic profile.

For translational and clinical researchers, JAX-CKB provides thousands of literature citations, FDA drug labels, and clinical trials relative to a tumor’s genomic mutation or profile, resulting in a clear and up-to-date picture of discoveries and active developments for a variety of biomarkers.

Current data includes:

  • Gene and variant descriptions
  • Drug indication status
  • Clinical Trials by indication
  • Treatment approaches
  • Efficacy evidence supporting response to treatment approaches by indication
  • Resistance evidence supporting resistance to treatments by indication

ACCESS JAX-CKB

Gene list used in JAX-CKB

JAX-CKB Gene List
ABL1 CDH1 FGFR2 JAK2 NPM1 SMARCB1
AKT1 CDKN2A FGFR3 JAK3 NRAS SMC3
ALK CEBPA FLT3 KDM6A PDGFRA SMO
APC CSF1R FOXL2 KDR PHF6 SRC
ASXL1 CSF3R GATA1 KIT PIK3CA SRSF2
ATM CTNNB1 GATA2 KRAS PTEN STAG2
ATRX DNMT3A GNA11 MAP2K1 PTPN11 STK11
BCOR EGFR GNAQ MET RAD21 TET2
BCORL1 ERBB2 GNAS MLH1 RB1 TP53
BRAF ERBB4 HNF1A KMT2A RET U2AF1
CALR ETV6 HRAS MPL RUNX1 VHL
CBL EZH2 IDH1 MSH6 SETBP1 ZRSR2
CBLB FBXW7 IDH2 MYD88 SF3B1
CBLC FGFR1 IKZF1 NOTCH1 SMAD4

Popular Therapy Hits in JAX-CKB

Drug Trade Name/Synonym
Everolimus Afinitor
Alectinib Alecensa 
Bevacizumab Avastin
Vandetanib Caprelsa 
Cabozantinib Cometriq; Cabometyx
Cobimetinib Cotellic 
Ramucirumab Cyramza 
Cetuximab Erbitux
Vismodegib Erivedge
Afatinib Gilotrif
Imatinib Gleevec
Trastuzumab Herceptin 
Palbociclib Ibrance 
Ibrutinib Imbruvica
Gefitinib Iressa
Ruxolitinib Jakafi 
Pembrolizumab Keytruda 
Lenvatinib Lenvima 
Olaparib Lynparza
Trametinib Mekinist
Sorafenib Nexavar 
Sonidegib Odomzo 
Nintedanib Ofev
Nivolumab Opdivo
Pertuzumab perjeta
Dasatinib Sprycel
Regorafenib Stivarga
Sutent Sunitinib
Dabrafenib Tafinlar 
Osimertinib Tagrisso
Erlotinib Tarceva
Nilotinib Tasigna
Temsirolimus Torisel 
Panitumumab Vectibix 
Pazopanib Votrient
Crizotinib Xalkori
Enzalutamide XTANDI 
Vemurafenib Zelboraf
Ceritinib Zykadia
BGJ398  
Binimetinib  MEK162
Buparlisib  BKM120
BYL719 Alpelisib
Cediranib  AZD-2171
Encorafenib LGX818
Ribociclib  LEE011
Rociletinib  CO-1686
Selumetinib AZD6244
Talazoparib  BMN-673
Veliparib  ABT-888